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serA serA AHB87496.1 AHB87496.1 pdhB pdhB acnB acnB eno eno pgl pgl pykF pykF gltA gltA sdhA sdhA maeB maeB gap2 gap2 pfk pfk accA accA pdhC pdhC accB accB rpiA rpiA pdhA pdhA fbaA fbaA glcK-1 glcK-1 rbcS rbcS rbcL rbcL gpmB gpmB fumC fumC prsA prsA gcvP gcvP accD accD gcvH gcvH sdhB sdhB metF metF accC accC tkt tkt pepC pepC prk prk eda-2 eda-2 gap gap talB talB glyA glyA pgk pgk pykA pykA cysK cysK rpe rpe ackA ackA gap1 gap1 folD folD gpm gpm pgi pgi gcvT gcvT ppsA ppsA cysE cysE lpdA lpdA acsA acsA tpiA tpiA hdrB hdrB AHB89555.1 AHB89555.1 zwf zwf fbp fbp gnd gnd AHB89608.1 AHB89608.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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serAD-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
AHB87496.1Isocitrate dehydrogenase. (358 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit PdhB; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase, AcnB; Belongs to the aconitase/IPM isomerase family. (868 aa)
eno2-phosphopyruvate hydratase (enolase) Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa)
pgl6-phosphogluconolactonase Pgl; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (241 aa)
pykFPyruvate kinase PykF; Belongs to the pyruvate kinase family. (477 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (382 aa)
sdhASuccinate dehydrogenase flavoprotein subunit SdhA. (576 aa)
maeBDecarboxylating NADP-dependent malic enzyme MaeB. (462 aa)
gap2NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase Gap2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (321 aa)
pfk6-phosphofructokinase Pfk; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (369 aa)
accAacetyl-CoA carboxylase carboxyltransferase alpha subunit AccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa)
pdhCPyruvate dehydrogenase dihydrolipoamide acetyltransferase E2 component PdhC. (414 aa)
accBacetyl-CoA carboxylase biotin carboxyl carrier protein AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa)
rpiARibose-5-phosphate isomerase A RpiA; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (235 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit PdhA; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
fbaAClass II fructose-1,6-bisphosphate aldolase FbaA; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
glcK-1Glucokinase GlcK; Belongs to the bacterial glucokinase family. (327 aa)
rbcSRibulose bisphosphate carboxylase small subunit RbcS. (118 aa)
rbcLRibulose bisophosphate carboxylase large subunit RbcL; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. (475 aa)
gpmBPhosphoglycerate mutase GpmB; Belongs to the phosphoglycerate mutase family. (468 aa)
fumCFumarate hydratase class II FumC; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
prsARibose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (329 aa)
gcvPGlycine dehydrogenase [decarboxylating] GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
accDacetyl-CoA carboxylase carboxyltransferase beta subunit AccD; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (309 aa)
gcvHGlycine cleavage system protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (335 aa)
metF5, 10-methylenetetrahydrofolate reductase MetF; Belongs to the methylenetetrahydrofolate reductase family. (319 aa)
accCacetyl-CoA carboxylase biotin carboxylase component AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
tktTransketolase Tkt; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
pepCPhosphoenolpyruvate carboxylase PepC; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1011 aa)
prkPhosphoribulokinase Prk. (334 aa)
eda-2Bifunctional 4-hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase Eda. (206 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase Gap; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
talBTransaldolase TalB; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (391 aa)
glyASerine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa)
pgkPhosphoglycerate kinase PgK; Belongs to the phosphoglycerate kinase family. (400 aa)
pykAPyruvate kinase PykA; Belongs to the pyruvate kinase family. (594 aa)
cysKCysteine synthase CysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (321 aa)
rpeRibulose-phosphate 3-epimerase Rpe; Belongs to the ribulose-phosphate 3-epimerase family. (231 aa)
ackAAcetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (409 aa)
gap1NAD-dependent glyceraldehyde-3-phosphate dehydrogenase Gap1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (306 aa)
gpm2,3-bisphosphoglycerate-independent phosphoglycerate mutase Gpm; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (531 aa)
pgiGlucose-6-phosphate isomerase Pgi; Belongs to the GPI family. (529 aa)
gcvTGlycine cleavage system aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
ppsAPhosphoenolpyruvate synthase PpsA; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa)
cysESerine acetyltransferase CysE. (246 aa)
lpdADihydrolipoamide dehydrogenase IpdA. (478 aa)
acsAacetyl-CoA synthetase AcsA; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
tpiATriosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa)
hdrBHeterodisulfide reductase subunit B HdrB. (299 aa)
AHB89555.1Pyruvate kinase family protein; Belongs to the pyruvate kinase family. (502 aa)
zwfGlucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
fbpFructose-1,6-bisphosphatase Fbp; Belongs to the FBPase class 1 family. (348 aa)
gnd6-phosphogluconate dehydrogenase Gnd; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (480 aa)
AHB89608.1Putative phosphoenolpyruvate synthase. (679 aa)
Your Current Organism:
Thermosynechococcus sp. NK55a
NCBI taxonomy Id: 1394889
Other names: T. sp. NK55a
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