STRINGSTRING
AB434_0015 AB434_0015 AB434_0023 AB434_0023 AB434_0029 AB434_0029 AB434_0032 AB434_0032 AB434_0209 AB434_0209 AB434_0258 AB434_0258 AB434_0274 AB434_0274 AB434_0303 AB434_0303 AB434_0344 AB434_0344 AB434_0374 AB434_0374 fni fni AB434_0458 AB434_0458 AB434_0461 AB434_0461 AB434_0463 AB434_0463 AB434_0478 AB434_0478 AB434_0594 AB434_0594 AB434_0697 AB434_0697 AB434_0724 AB434_0724 pcrB pcrB AB434_0795 AB434_0795 AB434_0796 AB434_0796 AB434_0797 AB434_0797 AB434_0798 AB434_0798 acpS acpS fabZ fabZ AB434_0977 AB434_0977 AB434_0978 AB434_0978 AB434_0979 AB434_0979 AB434_0980 AB434_0980 AB434_0982 AB434_0982 lipL lipL AB434_1044 AB434_1044 ispE ispE AB434_1178 AB434_1178 glmU glmU ispD ispD ispF ispF AB434_1391 AB434_1391 AB434_1419 AB434_1419 AB434_1420 AB434_1420 AB434_1421 AB434_1421 AB434_1444 AB434_1444 AB434_1446 AB434_1446 AB434_1481 AB434_1481 AB434_1506 AB434_1506 AB434_1545 AB434_1545 AB434_1547 AB434_1547 AB434_1549 AB434_1549 AB434_1673 AB434_1673 AB434_1719 AB434_1719 AB434_1781 AB434_1781 kdsA kdsA AB434_1919 AB434_1919 AB434_1961 AB434_1961 AB434_1962 AB434_1962 AB434_1993 AB434_1993 AB434_2021 AB434_2021 AB434_2026 AB434_2026 acpP acpP AB434_2069 AB434_2069 AB434_2070 AB434_2070 AB434_2099 AB434_2099 AB434_2160 AB434_2160 AB434_2239 AB434_2239 AB434_2287 AB434_2287 fabH fabH AB434_2323 AB434_2323 AB434_2367 AB434_2367 AB434_2520 AB434_2520 AB434_2545 AB434_2545 AB434_2577 AB434_2577 murG murG fapR fapR plsX plsX AB434_2702 AB434_2702 AB434_2703 AB434_2703 acpP-2 acpP-2 AB434_2773 AB434_2773 AB434_2774 AB434_2774 dxr dxr AB434_2816 AB434_2816 AB434_2821 AB434_2821 plsY plsY AB434_3080 AB434_3080 AB434_3125 AB434_3125 AB434_3126 AB434_3126 AB434_3170 AB434_3170 AB434_3297 AB434_3297 gpsA gpsA AB434_3321 AB434_3321 dxs dxs AB434_3407 AB434_3407 AB434_3414 AB434_3414 AB434_3415 AB434_3415 AB434_3434 AB434_3434 AB434_3435 AB434_3435 AB434_3437 AB434_3437 lipM lipM ispG ispG ispH ispH AB434_3506 AB434_3506 AB434_3564 AB434_3564 AB434_3728 AB434_3728 AB434_3729 AB434_3729 AB434_3730 AB434_3730 AB434_3760 AB434_3760 accA accA accD accD AB434_3816 AB434_3816 AB434_3981 AB434_3981 AB434_4005 AB434_4005 AB434_4006 AB434_4006 lipA lipA AB434_4065 AB434_4065 AB434_4066 AB434_4066 AB434_4067 AB434_4067 AB434_4073 AB434_4073 AB434_4083 AB434_4083 AB434_4084 AB434_4084 AB434_0001 AB434_0001 AB434_0002 AB434_0002 AB434_0003 AB434_0003 AB434_0005 AB434_0005 AB434_0006 AB434_0006 AB434_0008 AB434_0008 AB434_0009 AB434_0009
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AB434_0015Hypothetical protein. (479 aa)
AB434_00231,2-diacylglycerol 3-glucosyltransferase. (447 aa)
AB434_0029Diglucosyldiacylglycerol synthase. (389 aa)
AB434_0032Membrane protein. (727 aa)
AB434_0209Enoyl-[acyl-carrier-protein] reductase. (249 aa)
AB434_02582,3-butanediol dehydrogenase, S-alcohol forming, (S)-acetoin-specific. (257 aa)
AB434_0274Octaprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (289 aa)
AB434_0303Cytochrome P450. (456 aa)
AB434_03443-oxoacyl-[acyl-carrier-protein] synthase, KASIII. (332 aa)
AB434_0374Acyl-CoA hydrolase. (135 aa)
fniIsopentenyl-diphosphate delta-isomerase, FMN-dependent; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (343 aa)
AB434_0458Methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (318 aa)
AB434_0461Biotin carboxylase of methylcrotonyl-CoA carboxylase. (451 aa)
AB434_0463Isovaleryl-CoA dehydrogenase. (380 aa)
AB434_04783-hydroxybutyryl-CoA dehydrogenase. (319 aa)
AB434_05943-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (399 aa)
AB434_06972,3-butanediol dehydrogenase, S-alcohol forming, (S)-acetoin-specific. (257 aa)
AB434_0724Diacylglycerol kinase. (304 aa)
pcrB(S)-3-O-geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond- formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. (237 aa)
AB434_07953-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
AB434_07963-hydroxybutyryl-CoA dehydratase. (176 aa)
AB434_07973-hydroxybutyryl-CoA dehydratase. (73 aa)
AB434_07983-hydroxybutyryl-CoA dehydrogenase. (277 aa)
acpSHolo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (177 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase, FabZ form; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (141 aa)
AB434_0977Butyryl-CoA dehydrogenase. (380 aa)
AB434_0978Butyryl-CoA dehydrogenase. (378 aa)
AB434_09793-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AB434_0980Fe-S oxidoreductase. (714 aa)
AB434_0982Cardiolipin synthetase; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (399 aa)
lipLLipoate-protein ligase A; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (277 aa)
AB434_1044Glycosyl transferase, family 8. (264 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (286 aa)
AB434_1178Bona fide RidA/YjgF/TdcF/RutC subgroup. (124 aa)
glmUN-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (442 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (228 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa)
AB434_1391Acyl-ACP thioesterase. (313 aa)
AB434_1419Hypothetical protein. (226 aa)
AB434_1420Hypothetical protein. (161 aa)
AB434_1421Hypothetical protein. (294 aa)
AB434_1444Hydroxymethylglutaryl-CoA synthase. (394 aa)
AB434_14463-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AB434_1481Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY; Belongs to the PlsY family. (204 aa)
AB434_1506Acyl-CoA dehydrogenase. (414 aa)
AB434_1545Mevalonate kinase. (338 aa)
AB434_1547Diphosphomevalonate decarboxylase. (326 aa)
AB434_1549Phosphomevalonate kinase. (352 aa)
AB434_1673Tyrosine-protein kinase transmembrane modulator EpsC. (245 aa)
AB434_1719Hypothetical protein. (39 aa)
AB434_1781Butyryl-CoA dehydrogenase. (403 aa)
kdsA2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase; Belongs to the KdsA family. (280 aa)
AB434_1919Alcohol dehydrogenase. (328 aa)
AB434_19612-methylcitrate dehydratase. (482 aa)
AB434_1962Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (308 aa)
AB434_1993Acyl-CoA dehydrogenase. (552 aa)
AB434_2021Oxidoreductase of aldo/keto reductase family, subgroup 1. (273 aa)
AB434_20263-hydroxybutyryl-CoA dehydrogenase. (295 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (109 aa)
AB434_2069Butyryl-CoA dehydrogenase. (378 aa)
AB434_2070Butyryl-CoA dehydrogenase. (47 aa)
AB434_2099Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase. (345 aa)
AB434_2160Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (488 aa)
AB434_2239Enoyl-CoA hydratase. (260 aa)
AB434_2287O-succinylbenzoic acid--CoA ligase. (515 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (312 aa)
AB434_23233-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
AB434_2367Enoyl-[acyl-carrier-protein] reductase. (259 aa)
AB434_2520Glucose 1-dehydrogenase. (254 aa)
AB434_2545Inositol-1-monophosphatase. (264 aa)
AB434_2577Serine protease. (263 aa)
murGN-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (367 aa)
fapRPhosphate:acyl-ACP acyltransferase PlsX; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (193 aa)
plsXPhosphate:acyl-ACP acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (330 aa)
AB434_2702Malonyl CoA-acyl carrier protein transacylase. (312 aa)
AB434_27033-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
acpP-2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
AB434_2773Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (266 aa)
AB434_2774Phosphatidate cytidylyltransferase. (267 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (381 aa)
AB434_28163-oxoacyl-[acyl-carrier protein] reductase. (240 aa)
AB434_2821CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (192 aa)
plsYAcyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (199 aa)
AB434_30803-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AB434_3125MaoC family protein. (134 aa)
AB434_3126Hypothetical protein. (149 aa)
AB434_31701-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (194 aa)
AB434_3297Heptaprenyl diphosphate synthase component II; Belongs to the FPP/GGPP synthase family. (320 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (346 aa)
AB434_3321Phosphoesterase. (259 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
AB434_3407(2E,6E)-farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (289 aa)
AB434_3414Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
AB434_3415Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (160 aa)
AB434_34343-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
AB434_34353-hydroxybutyryl-CoA dehydrogenase. (288 aa)
AB434_3437Enoyl-CoA hydratase. (73 aa)
lipMLipoate-protein ligase A; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (278 aa)
ispG1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (321 aa)
AB434_3506Diacylglycerol kinase. (131 aa)
AB434_3564CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa)
AB434_3728Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
AB434_3729Fatty acid degradation regulator YsiA, TetR family. (197 aa)
AB434_3730Long-chain-fatty-acid--CoA ligase. (521 aa)
AB434_3760Bifunctional protein: zinc-containing alcohol dehydrogenase. (328 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
AB434_3816Acyl-coenzyme A synthetase. (524 aa)
AB434_3981Hypothetical protein. (213 aa)
AB434_4005Oxidoreductase of aldo/keto reductase family, subgroup 1. (285 aa)
AB434_4006Oxidoreductase of aldo/keto reductase family, subgroup 1. (280 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (306 aa)
AB434_4065Butyryl-CoA dehydrogenase. (594 aa)
AB434_40663-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AB434_4067Enoyl-CoA hydratase. (794 aa)
AB434_4073Hypothetical protein. (479 aa)
AB434_40831,2-diacylglycerol 3-glucosyltransferase. (235 aa)
AB434_40841,2-diacylglycerol 3-glucosyltransferase. (124 aa)
AB434_00013-ketoacyl-CoA thiolase. (53 aa)
AB434_00023-ketoacyl-CoA thiolase. (43 aa)
AB434_0003Enoyl-CoA hydratase. (164 aa)
AB434_0005Enoyl-CoA hydratase. (68 aa)
AB434_0006Enoyl-CoA hydratase. (41 aa)
AB434_0008Enoyl-CoA hydratase. (265 aa)
AB434_0009Enoyl-CoA hydratase. (69 aa)
Your Current Organism:
Bacillus coagulans
NCBI taxonomy Id: 1398
Other names: ATCC 7050, B. coagulans, BCRC 10606, Bacillus sp. NCIM 2323, CCM 2013, CCRC 10606, CCRC:10606, CCUG 7417, CFBP 4225, CIP 66.25, DSM 1, IFO 12583, IMET 10993, JCM 2257, LMG 6326, LMG:6326, Lactobacillus sp. T4, NBRC 12583, NCAIM B.01086, NCCB 48014, NCCB 77025, NCIB 9365, NCIMB 9365, NCTC 10334, NRRL NRS-609, VKM B-731
Server load: low (16%) [HD]