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SCP_0108040 SCP_0108040 SCP_0109960 SCP_0109960 SCP_0110660 SCP_0110660 SCP_0205740 SCP_0205740 DRE2 DRE2 SCP_0304750 SCP_0304750 SCP_0309120 SCP_0309120 CFD1 CFD1 SCP_0402370 SCP_0402370 SCP_0403670 SCP_0403670 SCP_0404310 SCP_0404310 SCP_0409870 SCP_0409870 NTH1 NTH1 SCP_0507410 SCP_0507410 SCP_0603920 SCP_0603920 SCP_0601320 SCP_0601320 SCP_0606350 SCP_0606350 SCP_0902290 SCP_0902290 SCP_0902320 SCP_0902320 SCP_0903810 SCP_0903810 NBP35 NBP35 SCP_1000860 SCP_1000860 SCP_1303410 SCP_1303410
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SCP_0108040Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (390 aa)
SCP_0109960Biotin synthase. (370 aa)
SCP_0110660Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (805 aa)
SCP_0205740Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (184 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (318 aa)
SCP_0304750DNA polymerase. (1638 aa)
SCP_0309120NADH-ubiquinone oxidoreductase 19.3 kDa subunit, mitochondrial; Belongs to the complex I 20 kDa subunit family. (227 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (308 aa)
SCP_0402370Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (556 aa)
SCP_0403670DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (507 aa)
SCP_0404310Glutamate synthase [NADPH]. (2145 aa)
SCP_0409870NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial. (264 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (427 aa)
SCP_0507410Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (642 aa)
SCP_0603920DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2232 aa)
SCP_0601320NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (497 aa)
SCP_0606350Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (270 aa)
SCP_0902290DNA polymerase. (1444 aa)
SCP_0902320Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily. (156 aa)
SCP_0903810DNA polymerase. (852 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (325 aa)
SCP_1000860Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (785 aa)
SCP_1303410Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (730 aa)
Your Current Organism:
Sparassis crispa
NCBI taxonomy Id: 139825
Other names: S. crispa
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