(46 nodes) Fatty acid biosynthesis network (Aspergillus parasiticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	P875_00086781	AMP-binding enzyme. (437 aa)
	aflA	3-oxoacyl-[acyl-carrier-protein] reductase; Fatty acid synthase alpha subunit; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide- derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins. The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PKS afl [...] (1671 aa)
	aflB	3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthase beta subunit; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide- derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins. The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PK [...] (1888 aa)
	aflM	Versicolorin reductase 1; Versicolorin reductase; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide-derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins. The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2). The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PKS aflC. AflC combines a hexanoyl st [...] (262 aa)
	P875_00076301	Zinc-binding dehydrogenase. (419 aa)
	P875_00076316	Enoyl-Acyl carrier protein reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1857 aa)
	P875_00108658	AMP-binding enzyme. (561 aa)
	P875_00117443	Enoyl-Acyl carrier protein reductase. (254 aa)
	P875_00076218	Short chain dehydrogenase. (259 aa)
	P875_00075862	Uncharacterized protein. (449 aa)
	P875_00117036	Acyl transferase domain protein; Belongs to the fungal fatty acid synthetase subunit beta family. (2079 aa)
	P875_00117088	Beta-ketoacyl synthase N-terminal domain protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1776 aa)
	P875_00117154	AMP-binding enzyme. (611 aa)
	P875_00117051	Beta-ketoacyl synthase C-terminal domain protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1734 aa)
	P875_00108565	AMP-binding enzyme. (576 aa)
	P875_00021687	Uncharacterized protein. (250 aa)
	P875_00117166	CoA-transferase family III. (576 aa)
	P875_00117371	CoA-transferase family III. (569 aa)
	P875_00127883	Alcohol dehydrogenase GroES-like domain protein. (336 aa)
	P875_00116954	Short chain dehydrogenase. (256 aa)
	P875_00117060	Acyl transferase domain protein; Belongs to the fungal fatty acid synthetase subunit beta family. (2026 aa)
	P875_00117241	Short chain dehydrogenase. (252 aa)
	P875_00021426	Tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like classical c SDR. (615 aa)
	P875_00010799	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR. (260 aa)
	P875_00127891	Enoyl-Acyl carrier protein reductase. (222 aa)
	P875_00064529	Short chain dehydrogenase. (272 aa)
	P875_00010876	FabG. (256 aa)
	P875_00064837	CoA-transferase family III. (447 aa)
	P875_00065065	Beta-ketoacyl synthase N-terminal domain protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (814 aa)
	P875_00064957	AMP-binding enzyme. (572 aa)
	P875_00086518	Enoyl-Acyl carrier protein reductase. (255 aa)
	P875_00034075	Meso-23-butanediol dehydrogenase-like classical c SDR. (276 aa)
	P875_00042624	Uncharacterized protein. (554 aa)
	P875_00042938	PKS_AT domain-containing protein; Belongs to the fungal fatty acid synthetase subunit beta family. (2125 aa)
	P875_00042921	Uncharacterized protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. (1629 aa)
	P875_00042747	CoA-transferase family III. (573 aa)
	P875_00086806	Uncharacterized protein. (93 aa)
	P875_00086565	CoA-transferase family III. (418 aa)
	P875_00042468	Eukaryotic long-chain fatty acid CoA synthetase LC-FACS. (698 aa)
	P875_00095438	CoA-transferase family III. (568 aa)
	P875_00086865	Enoyl-Acyl carrier protein reductase. (254 aa)
	P875_00042740	Malonyl-CoA synthetase MCS. (613 aa)
	P875_00095688	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (491 aa)
	P875_00042648	Classical c SDR. (254 aa)
	P875_00095581	Enoyl-Acyl carrier protein reductase. (255 aa)
	P875_00042289	Acetyl-CoA carboxylase central region. (2283 aa)

Your Current Organism:

Aspergillus parasiticus

NCBI taxonomy Id: 1403190
Other names: A. parasiticus SU-1, Aspergillus parasiticus SU-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
P875_00010799	P875_00010876	A0A0F0IGH1	A0A0F0IAR6	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	FabG.	0.600
P875_00010799	P875_00021426	A0A0F0IGH1	A0A0F0IH17	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like classical c SDR.	0.540
P875_00010799	P875_00021687	A0A0F0IGH1	A0A0F0IJZ7	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Uncharacterized protein.	0.510
P875_00010799	P875_00034075	A0A0F0IGH1	A0A0F0I5J6	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Meso-23-butanediol dehydrogenase-like classical c SDR.	0.510
P875_00010799	P875_00042648	A0A0F0IGH1	A0A0F0I549	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Classical c SDR.	0.849
P875_00010799	P875_00042921	A0A0F0IGH1	A0A0F0HZD0	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.862
P875_00010799	P875_00042938	A0A0F0IGH1	A0A0F0HZA4	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	PKS_AT domain-containing protein; Belongs to the fungal fatty acid synthetase subunit beta family.	0.848
P875_00010799	P875_00064529	A0A0F0IGH1	A0A0F0IDM0	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Short chain dehydrogenase.	0.540
P875_00010799	P875_00065065	A0A0F0IGH1	A0A0F0I9X2	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Beta-ketoacyl synthase N-terminal domain protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.930
P875_00010799	P875_00075862	A0A0F0IGH1	A0A0F0ILF9	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Uncharacterized protein.	0.473
P875_00010799	P875_00076218	A0A0F0IGH1	A0A0F0IM21	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Short chain dehydrogenase.	0.600
P875_00010799	P875_00076316	A0A0F0IGH1	A0A0F0IN54	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Enoyl-Acyl carrier protein reductase; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.891
P875_00010799	P875_00086518	A0A0F0IGH1	A0A0F0I5V5	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Enoyl-Acyl carrier protein reductase.	0.540
P875_00010799	P875_00086806	A0A0F0IGH1	A0A0F0I1Q9	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Uncharacterized protein.	0.510
P875_00010799	P875_00095581	A0A0F0IGH1	A0A0F0I542	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Enoyl-Acyl carrier protein reductase.	0.540
P875_00010799	P875_00116954	A0A0F0IGH1	A0A0F0IIK4	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Short chain dehydrogenase.	0.540
P875_00010799	P875_00117036	A0A0F0IGH1	A0A0F0ILF1	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Acyl transferase domain protein; Belongs to the fungal fatty acid synthetase subunit beta family.	0.854
P875_00010799	P875_00117051	A0A0F0IGH1	A0A0F0IK72	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Beta-ketoacyl synthase C-terminal domain protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.832
P875_00010799	P875_00117060	A0A0F0IGH1	A0A0F0III1	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Acyl transferase domain protein; Belongs to the fungal fatty acid synthetase subunit beta family.	0.832
P875_00010799	P875_00117088	A0A0F0IGH1	A0A0F0ILA6	Beta-Keto acyl carrier protein reductase BKR involved in Type II FAS classical c SDR.	Beta-ketoacyl synthase N-terminal domain protein; Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.	0.832