(90 nodes) Pyruvate metabolism network (Aspergillus parasiticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	P875_00117137	NAD dependent epimerase/dehydratase family protein. (350 aa)
	P875_00108876	FAD linked oxidases C-terminal domain protein. (573 aa)
	P875_00128016	Uncharacterized protein. (204 aa)
	P875_00127963	Aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family. (474 aa)
	P875_00127694	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1193 aa)
	P875_00010456	LMOFMN like protein. (404 aa)
	P875_00117080	Zn2-Cys6 binuclear cluster domain protein. (660 aa)
	P875_00127627	FMN-dependent dehydrogenase; Belongs to the cytochrome b5 family. (495 aa)
	P875_00117007	FMN-dependent dehydrogenase. (385 aa)
	P875_00117024	NAD dependent epimerase/dehydratase family protein. (339 aa)
	P875_00021952	FCB2FMN like protein. (417 aa)
	P875_00108749	Uncharacterized protein. (96 aa)
	P875_00117208	FAD linked oxidases C-terminal domain protein. (556 aa)
	P875_00021590	Type 1 glutamine amidotransferase-like domain protein. (234 aa)
	P875_00117515	NAD dependent epimerase/dehydratase family protein. (339 aa)
	P875_00076303	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (382 aa)
	P875_00095661	Wings apart-like protein regulation of heterochromatin. (810 aa)
	P875_00064631	Zinc-binding dehydrogenase. (575 aa)
	P875_00095671	Uncharacterized protein. (496 aa)
	P875_00064572	DJ-1/PfpI family protein. (230 aa)
	P875_00095559	Malate synthase; Belongs to the malate synthase family. (539 aa)
	P875_00138525	Complex I intermediate-associated protein 30 CIA30. (616 aa)
	P875_00065041	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (427 aa)
	P875_00033975	Uncharacterized protein. (535 aa)
	P875_00138350	Aldehyde dehydrogenase family protein. (496 aa)
	P875_00064691	Zn2-Cys6 binuclear cluster domain protein. (699 aa)
	P875_00034325	Pyruvate carboxyltransferase domain-containing protein. (644 aa)
	P875_00011072	Acylphosphatase; Belongs to the acylphosphatase family. (94 aa)
	P875_00010999	Uncharacterized protein. (596 aa)
	P875_00010895	Uncharacterized protein. (489 aa)
	P875_00138115	Lactate/malate dehydrogenase NAD binding domain protein; Belongs to the LDH/MDH superfamily. (330 aa)
	P875_00011182	PEPCKATP like protein. (556 aa)
	P875_00010469	Uncharacterized protein. (532 aa)
	P875_00138206	Cleft lip and palate transmembrane protein 1 CLPTM1. (641 aa)
	P875_00010368	Acetyl-coenzyme A synthetase. (670 aa)
	P875_00010674	Uncharacterized protein. (665 aa)
	P875_00010596	FAD binding domain protein. (472 aa)
	P875_00022076	Type 1 glutamine amidotransferase GATase1-like domain protein. (239 aa)
	P875_00022172	Aldehyde reductase extended e SDR. (382 aa)
	P875_00010326	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (463 aa)
	P875_00021777	Type 1 glutamine amidotransferase GATase1-like domain protein. (239 aa)
	P875_00021839	Uncharacterized protein. (238 aa)
	P875_00010380	GET complex subunit GET2. (289 aa)
	P875_00011304	Uncharacterized protein. (310 aa)
	P875_00021338	FCB2FMN like protein; Belongs to the cytochrome b5 family. (498 aa)
	P875_00011094	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (371 aa)
	P875_00010967	GloB. (292 aa)
	P875_00022060	Putative Candidatus pelagibacter aldehyde dehydrogenase DhaS-like protein; Belongs to the aldehyde dehydrogenase family. (498 aa)
	P875_00010796	Probable acetate kinase. (417 aa)
	P875_00010633	Aldehyde reductase extended e SDR. (344 aa)
	P875_00021384	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (405 aa)
	P875_00117363	Carbamoyl-phosphate synthase L chain ATP binding domain protein. (588 aa)
	P875_00076120	FMN-dependent dehydrogenase. (403 aa)
	P875_00076231	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (315 aa)
	P875_00076099	Alpha/beta hydrolase fold. (523 aa)
	P875_00076147	Lyase. (549 aa)
	P875_00075932	Metallo-beta-lactamase superfamily protein. (255 aa)
	P875_00127653	FMN-dependent dehydrogenase. (420 aa)
	P875_00075719	Aldehyde dehydrogenase family protein. (482 aa)
	P875_00053654	Arylsulfotransferase ASST. (912 aa)
	P875_00053602	Aldehyde dehydrogenase 2 YMR170c-like protein; Belongs to the aldehyde dehydrogenase family. (505 aa)
	P875_00042580	Dihydrolipoyl dehydrogenase. (512 aa)
	P875_00042533	Putative FMN-binding domain protein. (685 aa)
	P875_00042494	Aldehyde reductase extended e SDR. (334 aa)
	P875_00042522	Specific transcription factor domain protein. (731 aa)
	P875_00042259	Malic enzyme. (595 aa)
	P875_00042380	Aldehyde dehydrogenase 2 YMR170c-like protein; Belongs to the aldehyde dehydrogenase family. (477 aa)
	P875_00053425	Specific transcription factor domain protein. (1057 aa)
	P875_00053287	Bms1-type G domain-containing protein. (794 aa)
	P875_00086710	Specific transcription factor domain protein. (764 aa)
	P875_00086644	Malate dehydrogenase. (340 aa)
	P875_00086640	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (485 aa)
	P875_00042385	Uncharacterized protein. (622 aa)
	P875_00095553	FAD linked oxidases C-terminal domain protein. (811 aa)
	P875_00053370	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (305 aa)
	P875_00053134	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (513 aa)
	P875_00086551	NAD dependent epimerase/dehydratase family protein. (339 aa)
	P875_00095256	Metallo-beta-lactamase superfamily protein. (333 aa)
	P875_00042289	Acetyl-CoA carboxylase central region. (2283 aa)
	P875_00042884	Glyoxysomal and mitochondrial malate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
	P875_00042776	Aldehyde reductase extended e SDR. (330 aa)
	P875_00034293	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
	P875_00095453	Aldehyde dehydrogenase family protein. (483 aa)
	P875_00042516	Uncharacterized protein. (122 aa)
	P875_00033892	Aldehyde reductase extended e SDR. (351 aa)
	P875_00033863	Uncharacterized protein. (647 aa)
	P875_00033748	FAD binding domain protein. (1641 aa)
	P875_00086499	Acetyl-CoA hydrolase/transferase C-terminal domain protein. (525 aa)
	P875_00064641	NAD dependent epimerase/dehydratase family protein. (340 aa)
	P875_00064645	FMN-dependent dehydrogenase. (1086 aa)

Your Current Organism:

Aspergillus parasiticus

NCBI taxonomy Id: 1403190
Other names: A. parasiticus SU-1, Aspergillus parasiticus SU-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
P875_00010326	P875_00010368	A0A0F0IE27	A0A0F0ICG6	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Acetyl-coenzyme A synthetase.	0.906
P875_00010326	P875_00010895	A0A0F0IE27	A0A0F0IAU2	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Uncharacterized protein.	0.506
P875_00010326	P875_00011094	A0A0F0IE27	A0A0F0IFT3	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.516
P875_00010326	P875_00011304	A0A0F0IE27	A0A0F0IFA6	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Uncharacterized protein.	0.521
P875_00010326	P875_00021338	A0A0F0IE27	A0A0F0IFE8	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	FCB2FMN like protein; Belongs to the cytochrome b5 family.	0.610
P875_00010326	P875_00021384	A0A0F0IE27	A0A0F0IH60	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.516
P875_00010326	P875_00021952	A0A0F0IE27	A0A0F0IJE9	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	FCB2FMN like protein.	0.610
P875_00010326	P875_00022060	A0A0F0IE27	A0A0F0IGG5	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Putative Candidatus pelagibacter aldehyde dehydrogenase DhaS-like protein; Belongs to the aldehyde dehydrogenase family.	0.436
P875_00010326	P875_00033863	A0A0F0IE27	A0A0F0I674	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Uncharacterized protein.	0.521
P875_00010326	P875_00033975	A0A0F0IE27	A0A0F0I921	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Uncharacterized protein.	0.436
P875_00010326	P875_00034325	A0A0F0IE27	A0A0F0I9X3	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Pyruvate carboxyltransferase domain-containing protein.	0.894
P875_00010326	P875_00042259	A0A0F0IE27	A0A0F0I157	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Malic enzyme.	0.615
P875_00010326	P875_00042289	A0A0F0IE27	A0A0F0I494	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Acetyl-CoA carboxylase central region.	0.899
P875_00010326	P875_00042380	A0A0F0IE27	A0A0F0I1B3	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Aldehyde dehydrogenase 2 YMR170c-like protein; Belongs to the aldehyde dehydrogenase family.	0.436
P875_00010326	P875_00042884	A0A0F0IE27	A0A0F0I4D4	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Glyoxysomal and mitochondrial malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.442
P875_00010326	P875_00053134	A0A0F0IE27	A0A0F0I3X1	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.436
P875_00010326	P875_00053602	A0A0F0IE27	A0A0F0HZ29	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Aldehyde dehydrogenase 2 YMR170c-like protein; Belongs to the aldehyde dehydrogenase family.	0.436
P875_00010326	P875_00064645	A0A0F0IE27	A0A0F0I803	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	FMN-dependent dehydrogenase.	0.610
P875_00010326	P875_00064691	A0A0F0IE27	A0A0F0I9N7	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Zn2-Cys6 binuclear cluster domain protein.	0.436
P875_00010326	P875_00075719	A0A0F0IE27	A0A0F0IM51	Homocitrate synthase like protein catalytic TIM barrel domain protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.	Aldehyde dehydrogenase family protein.	0.436