STRINGSTRING
dnaK dnaK grpE grpE dnaJ dnaJ htpG htpG clpP clpP clpX clpX AMW77850.1 AMW77850.1 AMW77915.1 AMW77915.1 amiE amiE AMW78083.1 AMW78083.1 AMW78084.1 AMW78084.1 AMD27_04760 AMD27_04760 lon lon AMW78268.1 AMW78268.1 AMW78739.1 AMW78739.1 AMW80370.1 AMW80370.1 clpB clpB groEL groEL groS groS ftsH ftsH AMW79501.1 AMW79501.1 AMW79977.1 AMW79977.1 priA priA AMW79982.1 AMW79982.1 AMW79983.1 AMW79983.1 AMW79984.1 AMW79984.1 AMW79985.1 AMW79985.1 AMW79986.1 AMW79986.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (646 aa)
grpENucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (182 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (373 aa)
htpGHypothetical protein; Molecular chaperone. Has ATPase activity. (639 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (203 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (436 aa)
AMW77850.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
AMW77915.1Heat-shock protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the small heat shock protein (HSP20) family. (152 aa)
amiEAcylamide amidohydrolase; Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates. (347 aa)
AMW78083.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AMW78084.1AmiS/UreI transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AMD27_04760Peptidase M28; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (808 aa)
AMW78268.15-formyltetrahydrofolate cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (193 aa)
AMW78739.1Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
AMW80370.1Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M16 family. (456 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (859 aa)
groELMolecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
ftsHCell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (633 aa)
AMW79501.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
AMW79977.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (740 aa)
AMW79982.1Heat-shock protein Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. (291 aa)
AMW79983.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AMW79984.1MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
AMW79985.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (88 aa)
AMW79986.1Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
Your Current Organism:
Acinetobacter sp. TGLY2
NCBI taxonomy Id: 1407071
Other names: A. sp. TGL-Y2, Acinetobacter sp. TGL-Y2
Server load: low (12%) [HD]