(19 nodes) Valine, leucine and isoleucine biosynthesis, and Threonine biosynthetic process network (Halobacterium hubeiense)

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Your Input:
	hom	Homoserine dehydrogenase. (313 aa)
	pabC	Aminodeoxychorismate lyase. (284 aa)
	thrC2	Threonine synthase. (397 aa)
	asd	Aspartate-semialdehyde dehydrogenase. (343 aa)
	thrB	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa)
	leuB1	3-isopropylmalate dehydrogenase. (329 aa)
	leuD	3-isopropylmalate dehydratase small subunit. (204 aa)
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
	HHUB_3053	Uncharacterized protein. (78 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa)
	ilvN	Acetolactate synthase small subunit. (209 aa)
	ilvB	Acetolactate synthase large subunit. (590 aa)
	leuA1	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (586 aa)
	ilvA	Threonine ammonia-lyase. (408 aa)
	thrC3	Threonine synthase. (357 aa)
	ilvE	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
	thrC1	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (415 aa)
	lysC	Aspartate kinase; Belongs to the aspartokinase family. (394 aa)

Your Current Organism:

Halobacterium hubeiense

NCBI taxonomy Id: 1407499
Other names: H. hubeiense, HAMBI 3616, Halobacterium sp. JI20-1, strain JI20-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HHUB_3053	ilvB	HHUB_3053	HHUB_3056	Uncharacterized protein.	Acetolactate synthase large subunit.	0.800
HHUB_3053	ilvC	HHUB_3053	HHUB_3054	Uncharacterized protein.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.802
HHUB_3053	ilvN	HHUB_3053	HHUB_3055	Uncharacterized protein.	Acetolactate synthase small subunit.	0.802
HHUB_3053	leuA1	HHUB_3053	HHUB_3057	Uncharacterized protein.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.445
HHUB_3053	leuB1	HHUB_3053	HHUB_3050	Uncharacterized protein.	3-isopropylmalate dehydrogenase.	0.800
HHUB_3053	leuC	HHUB_3053	HHUB_3052	Uncharacterized protein.	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.802
HHUB_3053	leuD	HHUB_3053	HHUB_3051	Uncharacterized protein.	3-isopropylmalate dehydratase small subunit.	0.802
asd	hom	HHUB_2863	HHUB_1259	Aspartate-semialdehyde dehydrogenase.	Homoserine dehydrogenase.	0.979
asd	ilvB	HHUB_2863	HHUB_3056	Aspartate-semialdehyde dehydrogenase.	Acetolactate synthase large subunit.	0.438
asd	ilvC	HHUB_2863	HHUB_3054	Aspartate-semialdehyde dehydrogenase.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.459
asd	ilvD	HHUB_2863	HHUB_3127	Aspartate-semialdehyde dehydrogenase.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.614
asd	ilvE	HHUB_2863	HHUB_3410	Aspartate-semialdehyde dehydrogenase.	Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.494
asd	ilvN	HHUB_2863	HHUB_3055	Aspartate-semialdehyde dehydrogenase.	Acetolactate synthase small subunit.	0.631
asd	leuA1	HHUB_2863	HHUB_3057	Aspartate-semialdehyde dehydrogenase.	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.	0.475
asd	leuB1	HHUB_2863	HHUB_3050	Aspartate-semialdehyde dehydrogenase.	3-isopropylmalate dehydrogenase.	0.655
asd	leuC	HHUB_2863	HHUB_3052	Aspartate-semialdehyde dehydrogenase.	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.470
asd	lysC	HHUB_2863	HHUB_3743	Aspartate-semialdehyde dehydrogenase.	Aspartate kinase; Belongs to the aspartokinase family.	0.996
asd	pabC	HHUB_2863	HHUB_1617	Aspartate-semialdehyde dehydrogenase.	Aminodeoxychorismate lyase.	0.494
asd	thrB	HHUB_2863	HHUB_3044	Aspartate-semialdehyde dehydrogenase.	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.	0.660
asd	thrC1	HHUB_2863	HHUB_3655	Aspartate-semialdehyde dehydrogenase.	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.579