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guaAa2 guaAa2 HHUB_1033 HHUB_1033 arcC arcC pdxT pdxT HHUB_1134 HHUB_1134 guaAa1 guaAa1 mmcB mmcB gltB gltB dapE dapE gdhA1 gdhA1 HHUB_1904 HHUB_1904 gdhA2 gdhA2 proC proC proB proB proA proA purF purF cbiA cbiA cbiP cbiP trpG trpG pyrG pyrG carA carA carB carB speB speB purQ purQ pdaD pdaD hisH hisH glnA glnA fadM fadM argG argG argH argH argW argW argC argC argD argD argE argE argF argF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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guaAa2Glutamine amidotransferase (homolog to GMP synthase subunit A). (229 aa)
HHUB_1033Peptidase M20 family protein. (409 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (303 aa)
pdxTPyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa)
HHUB_1134Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (363 aa)
guaAa1GMP synthase (glutamine-hydrolyzing) subunit A; Catalyzes the synthesis of GMP from XMP. (183 aa)
mmcBmethylmalonyl-CoA mutase subunit B (cobalamin-binding subunit). (138 aa)
gltBGlutamate synthase large subunit. (1483 aa)
dapESuccinyl-diaminopimelate desuccinylase. (356 aa)
gdhA1Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa)
HHUB_1904Amidohydrolase domain protein. (406 aa)
gdhA2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (282 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (443 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (489 aa)
cbiACobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (432 aa)
cbiPAdenosylcobyrate synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (497 aa)
trpGAnthranilate synthase component 2. (199 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (546 aa)
carACarbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit; Belongs to the CarA family. (352 aa)
carBCarbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit; Belongs to the CarB family. (1077 aa)
speBAgmatinase; Belongs to the arginase family. (272 aa)
purQPhosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (224 aa)
pdaDPyruvoyl-dependent arginine decarboxylase. (157 aa)
hisHImidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
glnAGlutamine synthetase. (458 aa)
fadMProline dehydrogenase. (279 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa)
argHArgininosuccinate lyase. (506 aa)
argWProbable biosynthetic carrier protein ArgW. (54 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (370 aa)
argEAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (336 aa)
argFOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (293 aa)
Your Current Organism:
Halobacterium hubeiense
NCBI taxonomy Id: 1407499
Other names: H. hubeiense, HAMBI 3616, Halobacterium sp. JI20-1, strain JI20-1
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