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| | pheA | Prephenate dehydratase. (268 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase. (474 aa) |
| | dsa | Dihydrolipoamide S-acyltransferase. (488 aa) |
| | oxdhB | 2-oxo-3-methylvalerate dehydrogenase E1 component beta subunit. (325 aa) |
| | oxdhA1 | 2-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit. (371 aa) |
| | HHUB_1033 | Peptidase M20 family protein. (409 aa) |
| | gndA | 6-phosphogluconate dehydrogenase (NAD-dependent, decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH. (302 aa) |
| | citB1 | Aconitate hydratase; Gene: hly; product: serine protease halolysin (nonfunctional); EC_number: 3.4.21.-; gene has a frameshift. (661 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (94 aa) |
| | HHUB_1134 | Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (363 aa) |
| | ribE | Riboflavin synthase. (196 aa) |
| | hom | Homoserine dehydrogenase. (313 aa) |
| | glpE | Thiosulfate sulfurtransferase GlpE. (111 aa) |
| | HHUB_1275 | Homolog to glycine cleavage system protein T. (360 aa) |
| | HHUB_1283 | Probable oxidoreductase (short-chain dehydrogenase family). (246 aa) |
| | glcK | Glucokinase. (322 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (335 aa) |
| | azf | Glucose-6-phosphate 1-dehydrogenase (NAD); Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (252 aa) |
| | Suk2 | PfkB family kinase. (327 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (251 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (435 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (264 aa) |
| | aroB | 3-dehydroquinate synthase, type II; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (388 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (224 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (577 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (356 aa) |
| | HHUB_1473 | Peptidase M48 family protein (homolog to CAAX prenyl protease). (412 aa) |
| | ppsA | Phosphoenolpyruvate synthase. (749 aa) |
| | acaB1 | acetyl-CoA C-acetyltransferase. (388 aa) |
| | fdfT | Squalene synthase. (348 aa) |
| | acs1 | acyl-CoA synthetase. (654 aa) |
| | korA | Oxoglutarate--ferredoxin oxidoreductase alpha subunit. (580 aa) |
| | korB | Oxoglutarate--ferredoxin oxidoreductase beta subunit. (289 aa) |
| | HHUB_1549 | PHP domain protein. (256 aa) |
| | purNH | Phosphoribosylglycinamide formyltransferase / phosphoribosylaminoimidazolecarboxamide formyltransferase. (536 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (458 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase. (356 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (272 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (247 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | graD1 | Sugar nucleotidyltransferase. (322 aa) |
| | pabC | Aminodeoxychorismate lyase. (284 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa) |
| | aspC4 | Pyridoxal phosphate-dependent aminotransferase. (368 aa) |
| | ctaB | Protoheme IX geranylgeranyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (458 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (203 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (133 aa) |
| | aspC3 | Pyridoxal phosphate-dependent aminotransferase. (380 aa) |
| | HHUB_1722 | Homolog to phosphoribosylamine--glycine ligase. (465 aa) |
| | mvaD | Phosphomevalonate decarboxylase. (326 aa) |
| | thrC2 | Threonine synthase. (397 aa) |
| | HHUB_1804 | Glycoside hydrolase domain protein. (696 aa) |
| | HHUB_1813 | UbiA family prenyltransferase. (283 aa) |
| | aspC2 | Pyridoxal phosphate-dependent aminotransferase. (373 aa) |
| | metE3 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (383 aa) |
| | assA | Probable archaetidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (229 aa) |
| | ribL | FAD synthase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (142 aa) |
| | HHUB_1857 | Aldehyde dehydrogenase. (504 aa) |
| | panE | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa) |
| | HHUB_1934 | Phosphoglycolate phosphatase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (223 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (281 aa) |
| | fba | Fructose-bisphosphate aldolase, class 1. (263 aa) |
| | rocF | Arginase; Belongs to the arginase family. (301 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (328 aa) |
| | asnB | Asparagine synthase (glutamine-hydrolyzing). (375 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (708 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (269 aa) |
| | HHUB_2107 | DUF4147 domain protein. (442 aa) |
| | acaB3 | acetyl-CoA C-acetyltransferase catalytic subunit. (383 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (499 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (215 aa) |
| | adk2 | Probable adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (168 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (357 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (282 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (443 aa) |
| | HHUB_2241 | GMC family oxidoreductase. (531 aa) |
| | menE | o-succinylbenzoate--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. (487 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. (310 aa) |
| | menB | 1,4-dihydroxy-2-naphthoyl-CoA synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (304 aa) |
| | menD | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (585 aa) |
| | menF | Isochorismate synthase. (442 aa) |
| | HHUB_2337 | Probable S-adenosylmethionine-dependent methyltransferase. (197 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa) |
| | HHUB_2362 | Probable oxidoreductase (short-chain dehydrogenase family). (266 aa) |
| | HHUB_2373 | Uncharacterized protein. (281 aa) |
| | aspC6 | Pyridoxal phosphate-dependent aminotransferase. (385 aa) |
| | HHUB_2424 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa) |
| | HHUB_2436 | Thioesterase domain protein. (138 aa) |
| | HHUB_2449 | Probable oxidoreductase (short-chain dehydrogenase family). (262 aa) |
| | acd6 | glutaryl-CoA dehydrogenase. (390 aa) |
| | acs2 | acyl-CoA synthetase. (665 aa) |
| | acs8 | acyl-CoA synthetase. (662 aa) |
| | sdhC | Succinate dehydrogenase subunit C. (130 aa) |
| | sdhD | Succinate dehydrogenase subunit D. (120 aa) |
| | sdhB | Succinate dehydrogenase subunit B. (289 aa) |
| | sdhA | Succinate dehydrogenase subunit A. (610 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (428 aa) |
| | cysK | Cysteine synthase. (333 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | tyrA | Prephenate dehydrogenase. (243 aa) |
| | surE1 | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (258 aa) |
| | aroQ | Chorismate mutase. (88 aa) |
| | aroK | Shikimate kinase, archaeal-type. (284 aa) |
| | mat | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (406 aa) |
| | surE2 | 5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | suhB | Probable inositol-1(or 4)-monophosphatase / fructose-1,6-bisphosphatase, archaeal-type. (262 aa) |
| | ahbD | Alternative heme synthase AhbD. (360 aa) |
| | ahbC | Fe-coproporphyrin synthase AhbC. (406 aa) |
| | porB | Pyruvate--ferredoxin oxidoreductase beta subunit. (312 aa) |
| | porA | Pyruvate--ferredoxin oxidoreductase alpha subunit. (628 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (328 aa) |
| | HHUB_2771 | Isopentenyl phosphate kinase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. (245 aa) |
| | idsA2 | Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (348 aa) |
| | gltS | glutamate--tRNA(Glu/Gln) ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (585 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (160 aa) |
| | metE1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (353 aa) |
| | metE2 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (329 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (489 aa) |
| | HHUB_2813 | HAD superfamily hydrolase. (172 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa) |
| | HHUB_2835 | 5'-nucleotidase family hydrolase. (448 aa) |
| | HHUB_2839 | Pyridoxal phosphate-dependent aminotransferase. (396 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (343 aa) |
| | pccA | propionyl-CoA carboxylase biotin carboxylase component. (611 aa) |
| | pccX | propionyl-CoA carboxylase small subunit. (85 aa) |
| | pccB1 | propionyl-CoA carboxylase carboxyltransferase component. (516 aa) |
| | sucC | succinate--CoA ligase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (382 aa) |
| | sucD | succinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa) |
| | chlID | ATP-dependent cobaltochelatase subunit ChlID. (686 aa) |
| | gcvP2 | Glycine cleavage system protein P beta subunit. (473 aa) |
| | gcvP1 | Glycine cleavage system protein P alpha subunit. (444 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | hmgB | hydroxymethylglutaryl-CoA synthase. (445 aa) |
| | ctaA1 | Heme A synthase. (278 aa) |
| | trpG | Anthranilate synthase component 2. (199 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (531 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (214 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | HHUB_2980 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa) |
| | glpC | Glycerol-3-phosphate dehydrogenase subunit C. (455 aa) |
| | glpB | Glycerol-3-phosphate dehydrogenase subunit B. (424 aa) |
| | glpA | Glycerol-3-phosphate dehydrogenase subunit A; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (567 aa) |
| | idiA | Isopentenyl-diphosphate delta-isomerase, type I; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (207 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa) |
| | leuB1 | 3-isopropylmalate dehydrogenase. (329 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit. (204 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa) |
| | ilvN | Acetolactate synthase small subunit. (209 aa) |
| | ilvB | Acetolactate synthase large subunit. (590 aa) |
| | leuA1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa) |
| | uppS2 | Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific). (202 aa) |
| | sirC | Precorrin-2 oxidase / ferrochelatase. (218 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (435 aa) |
| | metE4 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (381 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (586 aa) |
| | adk1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | crtB | Phytoene synthase. (322 aa) |
| | ansA | Asparaginase family protein. (292 aa) |
| | icd | Isocitrate dehydrogenase (NADP). (419 aa) |
| | hmgA | hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family. (403 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (509 aa) |
| | HHUB_3246 | Probable phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (352 aa) |
| | oxdhA2 | Probable branched-chain amino acid dehydrogenase E1 component alpha subunit. (348 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (349 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (224 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (84 aa) |
| | katG | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (739 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (425 aa) |
| | acaB2 | acetyl-CoA C-acyltransferase. (381 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa) |
| | aceA | Isocitrate lyase. (350 aa) |
| | ilvA | Threonine ammonia-lyase. (408 aa) |
| | citZ | Citrate synthase. (378 aa) |
| | thrC3 | Threonine synthase. (357 aa) |
| | fadM | Proline dehydrogenase. (279 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (220 aa) |
| | idsA1 | Bifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (280 aa) |
| | menG | Probable demethylmenaquinone methyltransferase. (211 aa) |
| | crtY | Lycopene beta-cyclase. (236 aa) |
| | manC | Mannose-1-phosphate guanylyltransferase. (331 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (282 aa) |
| | pmm1 | Phosphohexomutase (phosphoglucomutase / phosphomannomutase); Belongs to the phosphohexose mutase family. (454 aa) |
| | hemD | uroporphyrinogen-III synthase. (241 aa) |
| | sirA | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (243 aa) |
| | hemC | Hydroxymethylbilane synthase (porphobilinogen deaminase). (394 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (445 aa) |
| | hemB | Porphobilinogen synthase; Belongs to the ALAD family. (328 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (240 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (121 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | ltaE | Threonine aldolase. (338 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argH | Argininosuccinate lyase. (506 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa) |
| | argB | Acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (278 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (370 aa) |
| | argF | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (293 aa) |
| | thrC1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (415 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa) |
| | serB | Phosphoserine phosphatase. (211 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (393 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa) |
| | cysK3 | Cysteine synthase. (310 aa) |
| | psd | Probable archaetidylserine decarboxylase; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily. (202 aa) |
| | mdh | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (304 aa) |
| | purO | Inosine-5'-monophosphate cyclohydrolase, archaeal-type; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (194 aa) |
| | lysC | Aspartate kinase; Belongs to the aspartokinase family. (394 aa) |
