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pheA pheA HHUB_1033 HHUB_1033 citB1 citB1 hisE hisE HHUB_1134 HHUB_1134 hom hom gap gap trpC trpC trpB trpB trpA trpA aroA-2 aroA-2 aroD aroD pykA pykA HHUB_1549 HHUB_1549 dapE dapE dapF dapF lysA lysA dapD dapD dapB dapB dapA dapA pabC pabC aroE aroE aspC4 aspC4 aspC3 aspC3 cysK1 cysK1 thrC2 thrC2 aspC2 aspC2 metE3 metE3 fba fba rocF rocF asnB asnB hisF hisF tpiA tpiA hisC hisC proC proC proB proB proA proA aspC6 aspC6 cysK cysK pgk pgk aroC aroC aroA aroA tyrA tyrA aroQ aroQ aroK aroK mat mat glyA glyA HHUB_2677 HHUB_2677 eno eno metE1 metE1 metE2 metE2 hisD hisD asd asd trpG trpG trpE trpE trpF trpF trpD trpD thrB thrB leuB1 leuB1 leuD leuD leuC leuC ilvC ilvC ilvN ilvN ilvB ilvB leuA1 leuA1 metE4 metE4 ilvD ilvD icd icd gpmI gpmI HHUB_3246 HHUB_3246 hisH hisH glnA glnA ilvA ilvA citZ citZ thrC3 thrC3 ilvE ilvE prsA prsA hisB hisB hisA hisA hisI hisI hisG hisG ltaE ltaE argG argG argH argH argX argX argC argC argB argB argD argD argE argE argF argF thrC1 thrC1 serA serA serB serB metX metX rpiA rpiA cysK3 cysK3 lysC lysC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pheAPrephenate dehydratase. (268 aa)
HHUB_1033Peptidase M20 family protein. (409 aa)
citB1Aconitate hydratase; Gene: hly; product: serine protease halolysin (nonfunctional); EC_number: 3.4.21.-; gene has a frameshift. (661 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (94 aa)
HHUB_1134Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (363 aa)
homHomoserine dehydrogenase. (313 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (335 aa)
trpCIndole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (251 aa)
trpBTryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (435 aa)
trpATryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa)
aroA-22-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (264 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (224 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (577 aa)
HHUB_1549PHP domain protein. (256 aa)
dapESuccinyl-diaminopimelate desuccinylase. (356 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (272 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (277 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (247 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
pabCAminodeoxychorismate lyase. (284 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa)
aspC4Pyridoxal phosphate-dependent aminotransferase. (368 aa)
aspC3Pyridoxal phosphate-dependent aminotransferase. (380 aa)
cysK1Cysteine synthase. (326 aa)
thrC2Threonine synthase. (397 aa)
aspC2Pyridoxal phosphate-dependent aminotransferase. (373 aa)
metE35-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (383 aa)
fbaFructose-bisphosphate aldolase, class 1. (263 aa)
rocFArginase; Belongs to the arginase family. (301 aa)
asnBAsparagine synthase (glutamine-hydrolyzing). (375 aa)
hisFImidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (269 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (215 aa)
hisCHistidinol-phosphate aminotransferase. (357 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (282 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (443 aa)
aspC6Pyridoxal phosphate-dependent aminotransferase. (385 aa)
cysKCysteine synthase. (333 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
tyrAPrephenate dehydrogenase. (243 aa)
aroQChorismate mutase. (88 aa)
aroKShikimate kinase, archaeal-type. (284 aa)
matS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (406 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
HHUB_2677Homolog to cysteine synthase. (333 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa)
metE15-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (353 aa)
metE25-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (329 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
asdAspartate-semialdehyde dehydrogenase. (343 aa)
trpGAnthranilate synthase component 2. (199 aa)
trpEAnthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (531 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (214 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa)
leuB13-isopropylmalate dehydrogenase. (329 aa)
leuD3-isopropylmalate dehydratase small subunit. (204 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (350 aa)
ilvNAcetolactate synthase small subunit. (209 aa)
ilvBAcetolactate synthase large subunit. (590 aa)
leuA12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa)
metE45-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (381 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (586 aa)
icdIsocitrate dehydrogenase (NADP). (419 aa)
gpmIPhosphoglycerate mutase, 2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (509 aa)
HHUB_3246Probable phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (352 aa)
hisHImidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa)
glnAGlutamine synthetase. (458 aa)
ilvAThreonine ammonia-lyase. (408 aa)
citZCitrate synthase. (378 aa)
thrC3Threonine synthase. (357 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (282 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (240 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (121 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
ltaEThreonine aldolase. (338 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa)
argHArgininosuccinate lyase. (506 aa)
argXProbable glutamate--argW ligase. (288 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (346 aa)
argBAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (278 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (370 aa)
argEAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (336 aa)
argFOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (293 aa)
thrC1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (415 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (527 aa)
serBPhosphoserine phosphatase. (211 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (393 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (224 aa)
cysK3Cysteine synthase. (310 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (394 aa)
Your Current Organism:
Halobacterium hubeiense
NCBI taxonomy Id: 1407499
Other names: H. hubeiense, HAMBI 3616, Halobacterium sp. JI20-1, strain JI20-1
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