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lpxP lpxP lpxK lpxK lpxL lpxL yaeT yaeT Epro_0448 Epro_0448 lpxD lpxD lpxC lpxC lpxA lpxA lpxA-2 lpxA-2 Epro_0453 Epro_0453 rimL rimL degT degT Epro_0456 Epro_0456 lpxB lpxB msbA msbA msbA-2 msbA-2 Epro_0460 Epro_0460 Epro_0461 Epro_0461 waaQ waaQ kdtA kdtA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxPPutative Lipid A biosynthesis acyltransferase. (300 aa)
lpxKPutative Tetraacyldisaccharide 4-kinase, lipid A 4kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (339 aa)
lpxLLipid A biosynthesis acyltransferase. (302 aa)
yaeTOuter membrane protein assembly factor YaeT. (752 aa)
Epro_0448Outer membrane protein. (197 aa)
lpxDUDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (445 aa)
lpxAUDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa)
lpxA-2Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa)
Epro_0453Hypothetical protein. (266 aa)
rimLN-acetyltransferase. (183 aa)
degTPleiotropic regulatory protein; Belongs to the DegT/DnrJ/EryC1 family. (364 aa)
Epro_0456Oxidoreductase family protein. (312 aa)
lpxBPutative Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (362 aa)
msbALipid A export ATP-binding/permease protein MsbA. (577 aa)
msbA-2Lipid A export ATP-binding/permease protein MsbA. (578 aa)
Epro_0460Exported protein of unknown function. (327 aa)
Epro_0461Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (486 aa)
waaQPutative lipopolysaccharide heptosyltransferase II. (558 aa)
kdtAThree-deoxy-d-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (426 aa)
Your Current Organism:
Endomicrobium proavitum
NCBI taxonomy Id: 1408281
Other names: Candidatus Endomicrobium sp. Rsa215, DSM 29378, E. proavitum, Endomicrobium proavitum Zheng et al. 2018, JCM 30189, JCM 32103, strain Rsa215
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