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aroC aroC aroK aroK ppnK ppnK argA argA panD panD Epro_0417 Epro_0417 Epro_0418 Epro_0418 hisD hisD hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI trpF trpF asd asd nadC nadC ribE ribE ribBA ribBA ribE-2 ribE-2 ribD ribD trpA trpA trpB trpB trpF-2 trpF-2 trpC trpC trpD trpD trpG trpG trpE trpE nadB nadB Epro_0749 Epro_0749 panC panC panB panB dapL dapL dapB dapB dapA dapA dapF dapF lysA lysA Epro_0764 Epro_0764 Epro_0765 Epro_0765 Epro_0766 Epro_0766 argH argH argG argG Epro_0769 Epro_0769 argD argD argB argB argF argF thrC thrC argJ argJ argC argC nadA nadA nadE nadE hom hom yfdZ yfdZ aroB aroB aroQ aroQ thrB thrB ask ask aroE aroE hisG hisG pheA pheA hisC hisC aroF aroF tyrA tyrA aroA aroA aatA aatA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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textmining
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aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (385 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
ppnKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (273 aa)
argAPutative N-acetyltransferase; Belongs to the acetyltransferase family. (152 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa)
Epro_0417Exported protein of unknown function. (176 aa)
Epro_0418ABC transporter, ATP-binding protein. (613 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (389 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (245 aa)
hisFImidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (266 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (131 aa)
trpFN-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
nadCPutative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (280 aa)
ribERiboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (406 aa)
ribE-2Riboflavin synthase, alpha subunit. (203 aa)
ribDDiaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (257 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpF-2N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (201 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (258 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa)
trpGAnthranilate synthase glutamine amidotransferase component. (193 aa)
trpEAnthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (489 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (522 aa)
Epro_0749Exported protein of unknown function. (171 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (277 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)
dapLLL-diaminopimelate aminotransferase. (386 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (257 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (270 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (412 aa)
Epro_0764Tetratricopeptide domain-containing protein. (342 aa)
Epro_0765Patatin. (317 aa)
Epro_0766Exported protein of unknown function. (386 aa)
argHArgininosuccinate lyase. (452 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa)
Epro_0769Conserved membrane protein of unknown function. (166 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (249 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (309 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (355 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (402 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa)
nadEGlutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (629 aa)
homHomoserine dehydrogenase. (428 aa)
yfdZLL-diaminopimelate aminotransferase. (400 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
askAspartokinase; Belongs to the aspartokinase family. (410 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (291 aa)
pheAChorismate mutase/prephenate dehydratase. (357 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
aroFPhospho-2-dehydro-3-deoxyheptonate aldolase. (339 aa)
tyrAPrephenate dehydrogenase. (274 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
aatAAspartate aminotransferase. (401 aa)
Your Current Organism:
Endomicrobium proavitum
NCBI taxonomy Id: 1408281
Other names: Candidatus Endomicrobium sp. Rsa215, DSM 29378, E. proavitum, Endomicrobium proavitum Zheng et al. 2018, JCM 30189, JCM 32103, strain Rsa215
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