(31 nodes) ATPase, AAA-type, core network (Pneumocystis jirovecii RU7)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	T551_02695	AAA domain-containing protein. (767 aa)
	T551_02740	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (417 aa)
	T551_02283	Replication factor C subunit 4. (351 aa)
	T551_02130	Hsp78-like protein; Belongs to the ClpA/ClpB family. (767 aa)
	T551_02160	ATP-dependent chaperone ClpB; Belongs to the ClpA/ClpB family. (901 aa)
	T551_02217	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (433 aa)
	T551_02253	AAA domain-containing protein; Belongs to the AAA ATPase family. (370 aa)
	T551_02258	Uncharacterized protein. (521 aa)
	T551_01864	Cell division control protein 48; Belongs to the AAA ATPase family. (818 aa)
	T551_01726	Uncharacterized protein. (758 aa)
	T551_01850	Replication factor C subunit 3. (356 aa)
	T551_01583	AAA domain-containing protein; Belongs to the AAA ATPase family. (743 aa)
	T551_00679	Uncharacterized protein. (789 aa)
	T551_01202	26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
	T551_00709	AAA domain-containing protein; Belongs to the AAA ATPase family. (430 aa)
	T551_01915	26S protease regulatory subunit 8. (377 aa)
	T551_00853	AAA domain-containing protein. (768 aa)
	T551_00857	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9. (1147 aa)
	T551_00829	Cell division control protein; Belongs to the CDC6/cdc18 family. (519 aa)
	T551_00536	Uncharacterized protein; Belongs to the AAA ATPase family. (441 aa)
	T551_00543	Replication factor C subunit 1. (960 aa)
	T551_00272	AAA domain-containing protein. (767 aa)
	PIM1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1090 aa)
	T551_03459	AAA domain-containing protein. (921 aa)
	T551_03306	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (436 aa)
	T551_03382	AAA domain-containing protein. (361 aa)
	T551_03185	Uncharacterized protein. (755 aa)
	T551_02811	AAA domain-containing protein. (1297 aa)
	T551_02919	Uncharacterized protein; Belongs to the AAA ATPase family. (436 aa)
	T551_02631	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (392 aa)
	T551_02028	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (721 aa)

Your Current Organism:

Pneumocystis jirovecii RU7

NCBI taxonomy Id: 1408657
Other names: P. jirovecii RU7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIM1	T551_00272	A0A0W4ZWT6	A0A0W4ZWR1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	AAA domain-containing protein.	0.755
PIM1	T551_00536	A0A0W4ZWT6	A0A0W4ZVQ0	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.595
PIM1	T551_02130	A0A0W4ZWT6	A0A0W4ZMB1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Hsp78-like protein; Belongs to the ClpA/ClpB family.	0.772
PIM1	T551_02160	A0A0W4ZWT6	A0A0W4ZME5	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	ATP-dependent chaperone ClpB; Belongs to the ClpA/ClpB family.	0.777
PIM1	T551_02695	A0A0W4ZWT6	A0A0W4ZIT7	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	AAA domain-containing protein.	0.789
T551_00272	PIM1	A0A0W4ZWR1	A0A0W4ZWT6	AAA domain-containing protein.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.755
T551_00272	T551_02695	A0A0W4ZWR1	A0A0W4ZIT7	AAA domain-containing protein.	AAA domain-containing protein.	0.517
T551_00536	PIM1	A0A0W4ZVQ0	A0A0W4ZWT6	Uncharacterized protein; Belongs to the AAA ATPase family.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.595
T551_00536	T551_01726	A0A0W4ZVQ0	A0A0W4ZQ05	Uncharacterized protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.434
T551_00543	T551_00679	A0A0W4ZVQ2	A0A0W4ZUE4	Replication factor C subunit 1.	Uncharacterized protein.	0.554
T551_00543	T551_00709	A0A0W4ZVQ2	A0A0W4ZUG9	Replication factor C subunit 1.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.589
T551_00543	T551_00829	A0A0W4ZVQ2	A0A0W4ZUZ2	Replication factor C subunit 1.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.453
T551_00543	T551_00853	A0A0W4ZVQ2	A0A0W4ZUW4	Replication factor C subunit 1.	AAA domain-containing protein.	0.836
T551_00543	T551_01583	A0A0W4ZVQ2	A0A0W4ZRL8	Replication factor C subunit 1.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.600
T551_00543	T551_01726	A0A0W4ZVQ2	A0A0W4ZQ05	Replication factor C subunit 1.	Uncharacterized protein.	0.552
T551_00543	T551_01850	A0A0W4ZVQ2	A0A0W4ZQC3	Replication factor C subunit 1.	Replication factor C subunit 3.	0.999
T551_00543	T551_01864	A0A0W4ZVQ2	A0A0W4ZNG8	Replication factor C subunit 1.	Cell division control protein 48; Belongs to the AAA ATPase family.	0.618
T551_00543	T551_02028	A0A0W4ZVQ2	A0A0W4ZNX9	Replication factor C subunit 1.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.512
T551_00543	T551_02253	A0A0W4ZVQ2	A0A0W4ZMN4	Replication factor C subunit 1.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.547
T551_00543	T551_02283	A0A0W4ZVQ2	A0A0W4ZKV3	Replication factor C subunit 1.	Replication factor C subunit 4.	0.999