64 items (Pneumocystis jirovecii RU7) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	T551_00939	Uncharacterized protein. (427 aa)
	T551_02600	CDT1_C domain-containing protein. (335 aa)
	T551_02260	CBFD_NFYB_HMF domain-containing protein. (215 aa)
	T551_02283	Replication factor C subunit 4. (351 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (354 aa)
	T551_02346	Uncharacterized protein. (326 aa)
	T551_02391	PA28_beta domain-containing protein. (223 aa)
	T551_02124	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (229 aa)
	T551_02170	Uncharacterized protein. (265 aa)
	T551_02181	Uncharacterized protein. (464 aa)
	T551_01874	Uncharacterized protein. (200 aa)
	T551_01969	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (708 aa)
	T551_02028	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (721 aa)
	T551_02029	Uncharacterized protein. (196 aa)
	T551_02049	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (444 aa)
	T551_02044	DNA polymerase. (1088 aa)
	T551_01715	Rhodanese domain-containing protein. (533 aa)
	T551_01770	CDK-activating kinase assembly factor MAT1. (326 aa)
	T551_01791	Zds_C domain-containing protein. (750 aa)
	T551_01850	Replication factor C subunit 3. (356 aa)
	T551_01454	Uncharacterized protein. (739 aa)
	T551_01457	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (193 aa)
	T551_01627	WD_REPEATS_REGION domain-containing protein. (374 aa)
	T551_01210	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (598 aa)
	T551_01218	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (215 aa)
	T551_01233	DNA_pol_E_B domain-containing protein. (634 aa)
	T551_01300	DNA polymerase. (1411 aa)
	T551_01314	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2179 aa)
	T551_02676	Sld5 domain-containing protein. (173 aa)
	T551_00929	Ubiquitin-40S ribosomal protein S27a. (153 aa)
	T551_01094	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (300 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (768 aa)
	T551_00786	Uncharacterized protein. (469 aa)
	T551_00843	Uncharacterized protein. (467 aa)
	T551_00847	Polyubiquitin. (181 aa)
	T551_00829	Cell division control protein; Belongs to the CDC6/cdc18 family. (519 aa)
	T551_00390	DNA helicase; Belongs to the MCM family. (881 aa)
	T551_05052	RPA_C domain-containing protein. (294 aa)
	T551_00453	DNA helicase; Belongs to the MCM family. (720 aa)
	T551_00494	DNA helicase. (855 aa)
	T551_00535	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (462 aa)
	T551_00543	Replication factor C subunit 1. (960 aa)
	T551_00021	ORC_WH_C domain-containing protein. (723 aa)
	T551_00017	DNA helicase; Belongs to the MCM family. (875 aa)
	T551_00033	E3 ubiquitin-protein ligase RBX1. (148 aa)
	T551_00216	Rad21_Rec8 domain-containing protein. (534 aa)
	T551_03647	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (375 aa)
	T551_03542	DNA helicase; Belongs to the MCM family. (862 aa)
	T551_03430	CYCLIN domain-containing protein; Belongs to the cyclin family. (349 aa)
	T551_03407	Serine/threonine-protein kinase pef1; Belongs to the protein kinase superfamily. (297 aa)
	T551_03452	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (430 aa)
	T551_03332	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (121 aa)
	T551_03382	AAA domain-containing protein. (361 aa)
	T551_03135	Uncharacterized protein. (146 aa)
	T551_03155	CBFD_NFYB_HMF domain-containing protein. (152 aa)
	T551_02953	Protein kinase domain-containing protein. (344 aa)
	T551_03018	Uncharacterized protein. (279 aa)
	T551_03071	Uncharacterized protein. (1474 aa)
	T551_03072	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (481 aa)
	T551_02820	Uncharacterized protein. (351 aa)
	T551_02849	Vezatin domain-containing protein. (621 aa)
	T551_02853	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
	T551_02613	Uncharacterized protein. (103 aa)
	T551_02622	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (629 aa)

Your Current Organism:

Pneumocystis jirovecii RU7

NCBI taxonomy Id: 1408657
Other names: P. jirovecii RU7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	MCM7	A0A0W4ZL32	A0A0W4ZUH8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.634
FEN1	T551_00017	A0A0W4ZL32	A0A0W4ZVZ1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.890
FEN1	T551_00033	A0A0W4ZL32	A0A0W4ZW10	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	E3 ubiquitin-protein ligase RBX1.	0.549
FEN1	T551_00390	A0A0W4ZL32	A0A0W4ZVB2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.811
FEN1	T551_00453	A0A0W4ZL32	A0A0W4ZVI1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase; Belongs to the MCM family.	0.879
FEN1	T551_00494	A0A0W4ZL32	A0A0W4ZVL4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA helicase.	0.879
FEN1	T551_00535	A0A0W4ZL32	A0A0W4ZVP5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.	0.795
FEN1	T551_00543	A0A0W4ZL32	A0A0W4ZVQ2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication factor C subunit 1.	0.888
FEN1	T551_00786	A0A0W4ZL32	A0A0W4ZUS3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.773
FEN1	T551_00829	A0A0W4ZL32	A0A0W4ZUZ2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.657
FEN1	T551_00843	A0A0W4ZL32	A0A0W4ZUV7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.941
FEN1	T551_00847	A0A0W4ZL32	A0A0W4ZUV9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Polyubiquitin.	0.435
FEN1	T551_00929	A0A0W4ZL32	A0A0W4ZTK0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ubiquitin-40S ribosomal protein S27a.	0.457
FEN1	T551_01094	A0A0W4ZL32	A0A0W4ZTX5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.480
FEN1	T551_01210	A0A0W4ZL32	A0A0W4ZRX6	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.831
FEN1	T551_01233	A0A0W4ZL32	A0A0W4ZS02	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA_pol_E_B domain-containing protein.	0.810
FEN1	T551_01300	A0A0W4ZL32	A0A0W4ZS79	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.876
FEN1	T551_01314	A0A0W4ZL32	A0A0W4ZS83	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.906
FEN1	T551_01457	A0A0W4ZL32	A0A0W4ZRA4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family.	0.542
FEN1	T551_01791	A0A0W4ZL32	A0A0W4ZQ44	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Zds_C domain-containing protein.	0.518