(36 nodes) Homologous recombination network (Pneumocystis jirovecii RU7)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	T551_01791	Zds_C domain-containing protein. (750 aa)
	T551_03443	PITH domain-containing protein. (152 aa)
	T551_03271	Uncharacterized protein. (681 aa)
	T551_03135	Uncharacterized protein. (146 aa)
	T551_03009	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (169 aa)
	T551_03027	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (681 aa)
	T551_03070	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (343 aa)
	T551_02847	Uncharacterized protein. (465 aa)
	T551_02613	Uncharacterized protein. (103 aa)
	T551_02617	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (276 aa)
	T551_02749	Uncharacterized protein. (99 aa)
	T551_02347	Uncharacterized protein. (796 aa)
	T551_02097	Uncharacterized protein. (362 aa)
	T551_02170	Uncharacterized protein. (265 aa)
	T551_02211	RECA_2 domain-containing protein. (350 aa)
	T551_02225	ERCC4 domain-containing protein. (573 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (811 aa)
	T551_02044	DNA polymerase. (1088 aa)
	T551_01692	Uncharacterized protein. (1093 aa)
	T551_01818	RECA_2 domain-containing protein. (369 aa)
	T551_01551	Uncharacterized protein. (673 aa)
	T551_01210	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (598 aa)
	T551_01250	Uncharacterized protein. (535 aa)
	T551_01011	Uncharacterized protein. (151 aa)
	T551_01123	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (654 aa)
	T551_01161	Uncharacterized protein. (98 aa)
	T551_00791	AAA_23 domain-containing protein. (1131 aa)
	T551_00790	DNA repair protein rad50. (172 aa)
	T551_00843	Uncharacterized protein. (467 aa)
	T551_05052	RPA_C domain-containing protein. (294 aa)
	T551_00451	Uncharacterized protein. (265 aa)
	T551_00053	Uncharacterized protein. (561 aa)
	T551_00246	RECA_2 domain-containing protein. (327 aa)
	T551_00269	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (603 aa)
	T551_00305	ERCC4 domain-containing protein. (499 aa)
	T551_00316	Uncharacterized protein. (862 aa)

Your Current Organism:

Pneumocystis jirovecii RU7

NCBI taxonomy Id: 1408657
Other names: P. jirovecii RU7

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIF1	T551_00246	A0A0W4ZNJ0	A0A0W4ZWK7	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	RECA_2 domain-containing protein.	0.566
PIF1	T551_00269	A0A0W4ZNJ0	A0A0W4ZWN5	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.751
PIF1	T551_00316	A0A0W4ZNJ0	A0A0W4ZWU8	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.481
PIF1	T551_00790	A0A0W4ZNJ0	A0A0W4ZUR2	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA repair protein rad50.	0.627
PIF1	T551_00791	A0A0W4ZNJ0	A0A0W4ZUP7	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	AAA_23 domain-containing protein.	0.627
PIF1	T551_01123	A0A0W4ZNJ0	A0A0W4ZU11	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.677
PIF1	T551_01210	A0A0W4ZNJ0	A0A0W4ZRX6	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.895
PIF1	T551_01250	A0A0W4ZNJ0	A0A0W4ZS24	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.851
PIF1	T551_01692	A0A0W4ZNJ0	A0A0W4ZPV8	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.824
PIF1	T551_01818	A0A0W4ZNJ0	A0A0W4ZQ89	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	RECA_2 domain-containing protein.	0.480
PIF1	T551_02044	A0A0W4ZNJ0	A0A0W4ZP06	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA polymerase.	0.511
PIF1	T551_02211	A0A0W4ZNJ0	A0A0W4ZMK1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	RECA_2 domain-containing protein.	0.566
PIF1	T551_02225	A0A0W4ZNJ0	A0A0W4ZML2	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	ERCC4 domain-containing protein.	0.702
PIF1	T551_02347	A0A0W4ZNJ0	A0A0W4ZL24	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.481
PIF1	T551_02617	A0A0W4ZNJ0	A0A0W4ZIJ4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.489
PIF1	T551_02749	A0A0W4ZNJ0	A0A0W4ZIZ7	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.669
PIF1	T551_03027	A0A0W4ZNJ0	A0A0W4ZGN6	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.758
PIF1	T551_03070	A0A0W4ZNJ0	A0A0W4ZGT1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.853
PIF1	T551_05052	A0A0W4ZNJ0	A0A0W4ZVC0	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	RPA_C domain-containing protein.	0.666
T551_00246	PIF1	A0A0W4ZWK7	A0A0W4ZNJ0	RECA_2 domain-containing protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	0.566