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kynA kynA acnA acnA gabD_2 gabD_2 gabD_1 gabD_1 lip2_1 lip2_1 icd icd pckA_1 pckA_1 ppsA ppsA fumC fumC oxdD oxdD GCA_001590885_02493 GCA_001590885_02493 gabD_3 gabD_3 prpD prpD prpC prpC prpB prpB mqo mqo maeA maeA fumA fumA acnB acnB pckA_2 pckA_2 aceK aceK aceA aceA aceB aceB ppc ppc mdh mdh gltA gltA sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB sucC sucC sucD sucD frdA frdA frdB frdB frdC frdC frdD frdD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kynAUnannotated protein; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (280 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
gabD_2Unannotated protein. (477 aa)
gabD_1Unannotated protein; Belongs to the aldehyde dehydrogenase family. (459 aa)
lip2_1Unannotated protein. (291 aa)
icdUnannotated protein. (417 aa)
pckA_1Unannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
ppsAUnannotated protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
oxdDUnannotated protein. (389 aa)
GCA_001590885_02493Unannotated protein. (271 aa)
gabD_3Unannotated protein; Belongs to the aldehyde dehydrogenase family. (491 aa)
prpDUnannotated protein. (483 aa)
prpCUnannotated protein; Belongs to the citrate synthase family. (387 aa)
prpBUnannotated protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa)
mqoUnannotated protein. (525 aa)
maeAUnannotated protein. (565 aa)
fumAUnannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (548 aa)
acnBUnannotated protein; Belongs to the aconitase/IPM isomerase family. (865 aa)
pckA_2Unannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (539 aa)
aceKUnannotated protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (584 aa)
aceAUnannotated protein. (435 aa)
aceBUnannotated protein; Belongs to the malate synthase family. (532 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (430 aa)
sdhCUnannotated protein. (89 aa)
sdhDUnannotated protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhAUnannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (569 aa)
sdhBUnannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (238 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
frdAUnannotated protein. (598 aa)
frdBUnannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (244 aa)
frdCUnannotated protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (130 aa)
frdDUnannotated protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (119 aa)
Your Current Organism:
Serratia ficaria
NCBI taxonomy Id: 1411141
Other names: S. ficaria NBRC 102596, Serratia ficaria NBRC 102596
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