(11 nodes) Base-excision repair, and AP endonuclease 1 network (Streptomyces sp. NRRLB1140)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOV99490.1	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
	KOV99551.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
	KOV99552.1	DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (489 aa)
	KOV99519.1	Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (160 aa)
	nfo	Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (288 aa)
	KOV97719.1	Metal ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
	KOV96039.1	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
	ung-2	uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (222 aa)
	KOV90858.1	Cysteine dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
	KOV90860.1	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
	KOV90959.1	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)

Your Current Organism:

Streptomyces sp. NRRLB1140

NCBI taxonomy Id: 1415549
Other names: S. sp. NRRL B-1140, Streptomyces sp. NRRL B-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOV90858.1	KOV90860.1	ADK65_35735	ADK65_35750	Cysteine dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.730
KOV90860.1	KOV90858.1	ADK65_35750	ADK65_35735	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.730
KOV90860.1	KOV90959.1	ADK65_35750	ADK65_36460	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
KOV90860.1	KOV99490.1	ADK65_35750	ADK65_17670	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
KOV90860.1	KOV99552.1	ADK65_35750	ADK65_17850	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.606
KOV90860.1	nfo	ADK65_35750	ADK65_21340	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.	0.519
KOV90860.1	ung-2	ADK65_35750	ADK65_30275	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.586
KOV90959.1	KOV90860.1	ADK65_36460	ADK65_35750	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.921
KOV90959.1	KOV96039.1	ADK65_36460	ADK65_28850	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
KOV90959.1	KOV99490.1	ADK65_36460	ADK65_17670	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.913
KOV90959.1	KOV99552.1	ADK65_36460	ADK65_17850	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
KOV90959.1	nfo	ADK65_36460	ADK65_21340	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.	0.958
KOV90959.1	ung-2	ADK65_36460	ADK65_30275	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.987
KOV96039.1	KOV90959.1	ADK65_28850	ADK65_36460	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
KOV96039.1	KOV99490.1	ADK65_28850	ADK65_17670	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.970
KOV96039.1	KOV99552.1	ADK65_28850	ADK65_17850	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.452
KOV96039.1	ung-2	ADK65_28850	ADK65_30275	Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.696
KOV97719.1	KOV99519.1	ADK65_24800	ADK65_17855	Metal ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.	0.550
KOV97719.1	KOV99551.1	ADK65_24800	ADK65_17845	Metal ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
KOV97719.1	KOV99552.1	ADK65_24800	ADK65_17850	Metal ABC transporter ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.602