(16 nodes) DNA helicase complex network (Streptomyces sp. NRRLB1140)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOV99811.1	DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
	KOV93485.1	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (825 aa)
	ku-2	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (301 aa)
	KOV96326.1	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
	KOV96822.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (726 aa)
	KOV97796.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (679 aa)
	KOV98944.1	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1118 aa)
	KOV98998.1	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
	KOW00057.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
	ku	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (346 aa)
	KOX00355.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
	KOX00281.1	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
	KOX00959.1	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (774 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (739 aa)
	ruvB	ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (356 aa)
	ruvA	ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)

Your Current Organism:

Streptomyces sp. NRRLB1140

NCBI taxonomy Id: 1415549
Other names: S. sp. NRRL B-1140, Streptomyces sp. NRRL B-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOV93485.1	KOV96326.1	ADK65_32695	ADK65_28710	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664
KOV93485.1	KOV96822.1	ADK65_32695	ADK65_26520	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOV97796.1	ADK65_32695	ADK65_24540	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOV98944.1	ADK65_32695	ADK65_19830	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.739
KOV93485.1	KOV98998.1	ADK65_32695	ADK65_19800	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
KOV93485.1	KOW00057.1	ADK65_32695	ADK65_16320	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOX00281.1	ADK65_32695	ADK65_14510	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOX00959.1	ADK65_32695	ADK65_11290	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	recG	ADK65_32695	ADK65_06070	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.	0.658
KOV93485.1	ruvB	ADK65_32695	ADK65_03485	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.	0.471
KOV96326.1	KOV93485.1	ADK65_28710	ADK65_32695	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664
KOV96326.1	KOV98944.1	ADK65_28710	ADK65_19830	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.664
KOV96326.1	KOV98998.1	ADK65_28710	ADK65_19800	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.877
KOV96326.1	KOX00355.1	ADK65_28710	ADK65_15015	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664
KOV96822.1	KOV93485.1	ADK65_26520	ADK65_32695	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV96822.1	KOV98944.1	ADK65_26520	ADK65_19830	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.721
KOV97796.1	KOV93485.1	ADK65_24540	ADK65_32695	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV97796.1	KOV98944.1	ADK65_24540	ADK65_19830	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.676
KOV98944.1	KOV93485.1	ADK65_19830	ADK65_32695	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.739
KOV98944.1	KOV96326.1	ADK65_19830	ADK65_28710	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664