(91 nodes) S-adenosyl-L-methionine-dependent methyltransferase superfamily network (Streptomyces sp. NRRLB1140)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOX00766.1	Restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
	KOX06522.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
	KOX06432.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
	KOX06447.1	Methyltransferase type 12; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
	KOX06461.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
	KOX06174.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
	KOX06148.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
	KOX06153.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
	KOX06156.1	Methyltransferase type 12; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
	KOX05004.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
	KOX04529.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
	KOX04362.1	macrocin-O-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
	KOX04369.1	31-O-demethyl-FK506 methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
	KOX04531.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
	KOX04467.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
	KOX04492.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
	rlmG	50S rRNA methyltransferase; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (376 aa)
	KOX03751.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
	KOX03767.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	KOX03815.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
	KOX03824.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
	KOX03291.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
	KOX03317.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
	KOX02224.1	3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
	KOX02278.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
	KOX01450.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
	KOX01491.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
	menG	Ubiquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (216 aa)
	KOX01144.1	Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methyltransferase superfamily. (512 aa)
	KOX01228.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	KOX00511.1	Arsenite S-adenosylmethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
	KOX00657.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
	KOX00693.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
	KOX00895.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (720 aa)
	prmC	SAM-dependent methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (278 aa)
	KOX00379.1	Spermidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
	KOW00044.1	Methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
	KOW00071.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
	KOV99808.1	RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (442 aa)
	KOV99488.1	NRPS-type-I PKS fusion protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (2463 aa)
	KOV99374.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
	KOV99382.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
	KOV99395.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
	KOV99082.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
	KOV99179.1	Translation initiation factor IF-2; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
	KOV98942.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
	KOV98972.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
	KOV98720.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
	KOV98758.1	S-adenosyl methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
	rsmH	16S rRNA methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (309 aa)
	KOV98576.1	Methyltransferase type 12; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
	KOV98593.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
	KOV98328.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
	KOV98605.1	Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
	KOV98609.1	rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
	KOV98423.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	KOV98619.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
	KOV98438.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
	KOV98642.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	KOV98644.1	Methyltransferase FkbM; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
	KOV98026.1	Cytochrome C oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
	KOV98062.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
	KOV97809.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
	KOV97569.1	S-adenosyl methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
	KOV97475.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (888 aa)
	KOV97492.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
	KOV97374.1	Spermine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
	KOV96863.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
	KOV97092.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
	KOV97096.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
	KOV97127.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
	egtD	histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (311 aa)
	KOV97058.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
	KOV96448.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
	KOV96463.1	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
	KOV96324.1	Transposase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (300 aa)
	KOV94948.1	Spermidine synthase-like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
	KOV94840.1	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
	KOV94969.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. (370 aa)
	KOV94972.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
	KOV94929.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
	KOV93925.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1750 aa)
	KOV92637.1	Trans-aconitate methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
	KOV92682.1	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
	KOV91593.1	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
	KOV91600.1	Derived by automated computational analysis using gene prediction method: Protein Homology. (788 aa)
	KOV91755.1	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
	KOV91717.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
	KOV91004.1	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
	tam	Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate. (272 aa)
	rsmA	Hypothetical protein; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (286 aa)

Your Current Organism:

Streptomyces sp. NRRLB1140

NCBI taxonomy Id: 1415549
Other names: S. sp. NRRL B-1140, Streptomyces sp. NRRL B-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOV91004.1	KOV91755.1	ADK65_36045	ADK65_35570	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91004.1	KOV93925.1	ADK65_36045	ADK65_31705	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.560
KOV91004.1	KOV94969.1	ADK65_36045	ADK65_30975	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family.	0.407
KOV91004.1	KOV97475.1	ADK65_36045	ADK65_25435	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.587
KOV91004.1	KOV98642.1	ADK65_36045	ADK65_22860	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
KOV91004.1	KOX02278.1	ADK65_36045	ADK65_08945	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91004.1	KOX03317.1	ADK65_36045	ADK65_07070	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91004.1	KOX06432.1	ADK65_36045	ADK65_01400	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91004.1	KOX06461.1	ADK65_36045	ADK65_01600	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91004.1	tam	ADK65_36045	ADK65_36260	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.	0.407
KOV91593.1	KOV93925.1	ADK65_34725	ADK65_31705	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.632
KOV91593.1	KOV94840.1	ADK65_34725	ADK65_30695	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.509
KOV91593.1	KOV97475.1	ADK65_34725	ADK65_25435	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.786
KOV91593.1	KOV99488.1	ADK65_34725	ADK65_17645	Ubiquinone biosynthesis methyltransferase UbiE; Derived by automated computational analysis using gene prediction method: Protein Homology.	NRPS-type-I PKS fusion protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.494
KOV91755.1	KOV91004.1	ADK65_35570	ADK65_36045	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91755.1	KOV93925.1	ADK65_35570	ADK65_31705	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.721
KOV91755.1	KOV97127.1	ADK65_35570	ADK65_27770	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.439
KOV91755.1	KOV97475.1	ADK65_35570	ADK65_25435	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.728
KOV91755.1	KOV98644.1	ADK65_35570	ADK65_22890	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase FkbM; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407
KOV91755.1	KOX03815.1	ADK65_35570	ADK65_06450	Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.407