(42 nodes) Mismatch repair network (Streptomyces sp. NRRLB1140)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOV90908.1	Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
	xseB	Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (84 aa)
	xseA	Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (402 aa)
	KOV91597.1	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (664 aa)
	KOV92727.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
	KOV93485.1	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (825 aa)
	ligB	ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)
	KOV96326.1	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
	KOV96822.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (726 aa)
	KOV97571.1	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
	KOV97540.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
	KOV97796.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (679 aa)
	KOV98056.1	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1181 aa)
	KOV98463.1	Chemical-damaging agent resistance protein C; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
	KOV98462.1	Chemical-damaging agent resistance protein C; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
	KOV98255.1	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
	KOV99531.1	Iron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
	KOV98944.1	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1118 aa)
	lexA	LexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (240 aa)
	KOV98998.1	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
	KOV98760.1	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (215 aa)
	KOV98232.1	Toxic cation resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
	KOV98937.1	Stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
	KOV98710.1	Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
	KOV99430.1	Tellurium resistance protein terZ; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
	KOV99903.1	TerD-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
	KOW00057.1	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
	KOW00005.1	Chemical-damaging agent resistance protein C; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
	KOX00251.1	DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
	KOX00147.1	Stress-induced protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
	KOX00355.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
	KOX00281.1	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
	KOX00589.1	Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	KOX00476.1	DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (854 aa)
	KOX00959.1	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (774 aa)
	KOX01148.1	DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
	KOX02546.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
	KOX04558.1	Chemical-damaging agent resistance protein C; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
	KOX05024.1	DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
	KOX06424.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
	KOX06349.1	3'-5' exonuclease of DNA polymerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
	KOV99367.1	Export associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (671 aa)

Your Current Organism:

Streptomyces sp. NRRLB1140

NCBI taxonomy Id: 1415549
Other names: S. sp. NRRL B-1140, Streptomyces sp. NRRL B-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOV90908.1	KOV98710.1	ADK65_36095	ADK65_20435	Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
KOV90908.1	KOX00589.1	ADK65_36095	ADK65_12975	Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.450
KOV91597.1	KOV93485.1	ADK65_34760	ADK65_32695	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.854
KOV91597.1	KOV98944.1	ADK65_34760	ADK65_19830	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.854
KOV91597.1	KOV98998.1	ADK65_34760	ADK65_19800	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
KOV91597.1	KOX00355.1	ADK65_34760	ADK65_15015	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.854
KOV91597.1	KOX00476.1	ADK65_34760	ADK65_12185	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.631
KOV91597.1	KOX01148.1	ADK65_34760	ADK65_10600	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.607
KOV91597.1	KOX02546.1	ADK65_34760	ADK65_08060	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.592
KOV93485.1	KOV91597.1	ADK65_32695	ADK65_34760	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.854
KOV93485.1	KOV96326.1	ADK65_32695	ADK65_28710	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Recombinase RecB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.664
KOV93485.1	KOV96822.1	ADK65_32695	ADK65_26520	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOV97796.1	ADK65_32695	ADK65_24540	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOV98944.1	ADK65_32695	ADK65_19830	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.	0.739
KOV93485.1	KOV98998.1	ADK65_32695	ADK65_19800	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
KOV93485.1	KOW00057.1	ADK65_32695	ADK65_16320	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOX00251.1	ADK65_32695	ADK65_15840	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.450
KOV93485.1	KOX00281.1	ADK65_32695	ADK65_14510	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503
KOV93485.1	KOX00589.1	ADK65_32695	ADK65_12975	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.518
KOV93485.1	KOX00959.1	ADK65_32695	ADK65_11290	ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.503