(9 nodes) Non-homologous end-joining network (Streptomyces sp. NRRLB1140)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KOV92584.1	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
	nusA	Transcription elongation factor NusA; Participates in both transcription termination and antitermination. (328 aa)
	KOX01477.1	Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
	ku	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (346 aa)
	KOX00361.1	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
	KOV98359.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
	KOV97883.1	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
	KOV97908.1	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
	ku-2	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (301 aa)

Your Current Organism:

Streptomyces sp. NRRLB1140

NCBI taxonomy Id: 1415549
Other names: S. sp. NRRL B-1140, Streptomyces sp. NRRL B-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KOV92584.1	KOV97883.1	ADK65_33780	ADK65_24305	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
KOV92584.1	KOV97908.1	ADK65_33780	ADK65_24330	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
KOV92584.1	KOX00361.1	ADK65_33780	ADK65_15075	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.886
KOV92584.1	ku	ADK65_33780	ADK65_15070	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.889
KOV92584.1	ku-2	ADK65_33780	ADK65_29425	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.889
KOV97883.1	KOV92584.1	ADK65_24305	ADK65_33780	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.993
KOV97883.1	KOV97908.1	ADK65_24305	ADK65_24330	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
KOV97883.1	KOX00361.1	ADK65_24305	ADK65_15075	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
KOV97883.1	ku	ADK65_24305	ADK65_15070	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.877
KOV97883.1	ku-2	ADK65_24305	ADK65_29425	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.820
KOV97908.1	KOV92584.1	ADK65_24330	ADK65_33780	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
KOV97908.1	KOV97883.1	ADK65_24330	ADK65_24305	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
KOV97908.1	KOX00361.1	ADK65_24330	ADK65_15075	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KOV97908.1	ku	ADK65_24330	ADK65_15070	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.887
KOV97908.1	ku-2	ADK65_24330	ADK65_29425	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.925
KOX00361.1	KOV92584.1	ADK65_15075	ADK65_33780	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.886
KOX00361.1	KOV97883.1	ADK65_15075	ADK65_24305	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
KOX00361.1	KOV97908.1	ADK65_15075	ADK65_24330	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KOX00361.1	ku	ADK65_15075	ADK65_15070	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.985
KOX00361.1	ku-2	ADK65_15075	ADK65_29425	ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.	0.891