STRINGSTRING
cysK cysK KRK99375.1 KRK99375.1 KRK94122.1 KRK94122.1 KRK93663.1 KRK93663.1 mtnN mtnN rlmH rlmH argC argC argJ argJ argB argB argD argD KRK99083.1 KRK99083.1 KRK99096.1 KRK99096.1 KRK99119.1 KRK99119.1 ald ald trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA pxpB pxpB KRK92402.1 KRK92402.1 pxpA pxpA KRK92406.1 KRK92406.1 thrB thrB KRK92420.1 KRK92420.1 KRK92421.1 KRK92421.1 KRK92422.1 KRK92422.1 KRK92423.1 KRK92423.1 KRK92424.1 KRK92424.1 phnC phnC KRK92426.1 KRK92426.1 KRK92427.1 KRK92427.1 phnX phnX phnW phnW KRK92184.1 KRK92184.1 KRK92185.1 KRK92185.1 KRK92186.1 KRK92186.1 KRK99023.1 KRK99023.1 KRK99024.1 KRK99024.1 KRK99025.1 KRK99025.1 KRK99026.1 KRK99026.1 KRK99027.1 KRK99027.1 KRK99028.1 KRK99028.1 pepV pepV KRK99032.1 KRK99032.1 ccpA ccpA KRK99034.1 KRK99034.1 KRK92033.1 KRK92033.1 metE metE metF metF KRK91887.1 KRK91887.1 KRK91888.1 KRK91888.1 KRK98940.1 KRK98940.1 KRK98941.1 KRK98941.1 hisC hisC hisE hisE hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisD hisD hisG hisG hisZ hisZ hisJ hisJ KRK98953.1 KRK98953.1 KRK98954.1 KRK98954.1 KRK98955.1 KRK98955.1 KRK98368.1 KRK98368.1 KRK91472.1 KRK91472.1 luxS luxS KRK99776.1 KRK99776.1 KRK99785.1 KRK99785.1 KRK98349.1 KRK98349.1 pepX pepX KRK91099.1 KRK91099.1 proB proB KRK91101.1 KRK91101.1 proA proA KRK91120.1 KRK91120.1 KRK91149.1 KRK91149.1 sdaAA sdaAA sdaAB sdaAB KRK91152.1 KRK91152.1 KRK91153.1 KRK91153.1 KRK91154.1 KRK91154.1 tdcB tdcB ald-2 ald-2 arcC arcC KRK90875.1 KRK90875.1 arcD arcD argF argF arcA arcA metK metK asd asd KRK90956.1 KRK90956.1 dapB dapB dapA dapA KRK90959.1 KRK90959.1 dapD dapD lysA lysA KRK90962.1 KRK90962.1 dapF dapF argG argG argH argH proC proC KRK90738.1 KRK90738.1 KRK90770.1 KRK90770.1 KRK90771.1 KRK90771.1 KRK90772.1 KRK90772.1 KRK90564.1 KRK90564.1 KRK97296.1 KRK97296.1 KRK90373.1 KRK90373.1 KRK90374.1 KRK90374.1 KRK90229.1 KRK90229.1 KRK99720.1 KRK99720.1 KRK96621.1 KRK96621.1 KRK95501.1 KRK95501.1 KRK95502.1 KRK95502.1 KRK95156.1 KRK95156.1 mmuM mmuM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysKCysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa)
KRK99375.1Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-serine, forming acetyl-L-serine; Belongs to the MetA family. (264 aa)
KRK94122.1Putative NADH oxidase (putative). (570 aa)
KRK93663.1Aminopeptidase N. (843 aa)
mtnNMethylthioadenosine nucleosidase (nucleoside phosphorylase); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (229 aa)
rlmHrRNA large subunit methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (159 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
argJBifunctional ornithine acetyltransferase N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (250 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (386 aa)
KRK99083.1Hypothetical protein. (218 aa)
KRK99096.1Prolyl aminopeptidase; Releases the N-terminal proline from various substrates. Belongs to the peptidase S33 family. (308 aa)
KRK99119.1Cystathionine gamma-lyase. (379 aa)
aldAlanine dehydrogenase. (371 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
trpCIndole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (259 aa)
trpFN-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (183 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (402 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
pxpBAllophanate hydrolase. (245 aa)
KRK92402.1Hypothetical protein. (338 aa)
pxpAHypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (249 aa)
KRK92406.1Manganese transporter NRAMP. (409 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (274 aa)
KRK92420.1Threonine synthase. (498 aa)
KRK92421.1Homoserine dehydrogenase. (390 aa)
KRK92422.1Aspartate kinase; Belongs to the aspartokinase family. (441 aa)
KRK92423.1Oxidoreductase. (289 aa)
KRK92424.1Phosphonate ABC superfamily ATP binding cassette transporter, binding protein. (347 aa)
phnCPhosphonates ABC transporter, ATP-binding protein; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (251 aa)
KRK92426.1Phosphonate ABC transporter, inner membrane subunit. (263 aa)
KRK92427.1Binding-protein-dependent transport systems inner membrane component. (283 aa)
phnXPhosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. (264 aa)
phnW2-aminoethylphosphonate--pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (363 aa)
KRK92184.1Amino acid transporter. (483 aa)
KRK92185.1Ornithine decarboxylase. (697 aa)
KRK92186.1Aluminum resistance protein. (420 aa)
KRK99023.1Hypothetical protein. (202 aa)
KRK99024.1HAD superfamily hydrolase; Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro; Belongs to the HAD-like hydrolase superfamily. NagD family. (258 aa)
KRK99025.1Hypothetical protein. (176 aa)
KRK99026.15-nucleotidase 2,3-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. (455 aa)
KRK99027.1Phosphoesterase or phosphohydrolase. (203 aa)
KRK99028.1Hypothetical protein. (110 aa)
pepVDipeptidase PepV. (465 aa)
KRK99032.1Hypothetical protein. (99 aa)
ccpACcpA transcriptional regulator (catabolic control protein A). (333 aa)
KRK99034.1Xaa-Pro dipeptidase. (366 aa)
KRK92033.1GNAT family acetyltransferase. (160 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (753 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)
KRK91887.1Aminoacylase. (293 aa)
KRK91888.1Isoleucine patch superfamily acetyltransferase. (197 aa)
KRK98940.1Hypothetical protein. (209 aa)
KRK98941.1Phosphate transporter family protein. (338 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (110 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (90 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (239 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa)
hisBImidazoleglycerol-phosphate dehydratase. (194 aa)
hisDBifunctional histidinal dehydrogenase histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (213 aa)
hisZPutative histidine--tRNA ligase (putative); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (388 aa)
hisJHistidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (276 aa)
KRK98953.1Integral membrane protein. (187 aa)
KRK98954.1ArsR SmtB family transcriptional regulator. (110 aa)
KRK98955.1Putative malate transport protein (putative). (308 aa)
KRK98368.1Hypothetical protein; Belongs to the purine-cytosine permease (2.A.39) family. (450 aa)
KRK91472.1Cystathionine beta-lyase. (380 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa)
KRK99776.1Cysteine synthase. (303 aa)
KRK99785.1Methionine synthase. (375 aa)
KRK98349.1Aminopeptidase C; Belongs to the peptidase C1 family. (447 aa)
pepXX-prolyl-dipeptidyl aminopeptidase; Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline; Belongs to the peptidase S15 family. (806 aa)
KRK91099.1Hypothetical protein. (77 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (270 aa)
KRK91101.1Transcriptional regulator. (139 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (441 aa)
KRK91120.1Neutral endopeptidase. (645 aa)
KRK91149.1Dipeptidase. (478 aa)
sdaAAL-serine dehydratase, iron-sulfur-dependent, subunit alpha. (288 aa)
sdaABL-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (223 aa)
KRK91152.1Dipeptidase. (463 aa)
KRK91153.1Hypothetical protein. (118 aa)
KRK91154.1OPT family oligopeptide transporter. (637 aa)
tdcBThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (345 aa)
ald-2Alanine dehydrogenase. (368 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (313 aa)
KRK90875.1Transaminase. (371 aa)
arcDAmino acid transporter. (470 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (345 aa)
arcAArginine deiminase. (409 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (416 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (353 aa)
KRK90956.1Aspartate transaminase. (394 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (257 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
KRK90959.1M20 m25 m40 family peptidase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (385 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (234 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (447 aa)
KRK90962.1Aspartate kinase; Belongs to the aspartokinase family. (452 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (324 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
argHArgininosuccinate lyase. (460 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (256 aa)
KRK90738.1Cysteine aminopeptidase; Belongs to the peptidase C1 family. (443 aa)
KRK90770.1Amino acid transporter. (461 aa)
KRK90771.1Aminotransferase. (390 aa)
KRK90772.1AEC family permease. (318 aa)
KRK90564.1Lactoylglutathione lyase related lyase. (127 aa)
KRK97296.1Malate permease. (320 aa)
KRK90373.1Hypothetical protein. (57 aa)
KRK90374.1Succinyl-diaminopimelate desuccinylase. (406 aa)
KRK90229.1Branched-chain amino acid aminotransferase. (343 aa)
KRK99720.1N6-adenine-specific DNA methylase; Belongs to the methyltransferase superfamily. (371 aa)
KRK96621.1Arginase; Belongs to the arginase family. (282 aa)
KRK95501.1Hypothetical protein. (124 aa)
KRK95502.1Cystathionine beta-lyase. (397 aa)
KRK95156.1Xaa-Pro dipeptidase. (353 aa)
mmuMHomocysteine methyltransferase. (314 aa)
Your Current Organism:
Lactobacillus futsaii
NCBI taxonomy Id: 1423818
Other names: L. futsaii JCM 17355, Lactobacillus futsaii JCM 17355, Lactobacillus futsaii YM 0097, Lactobacillus sp. YM 0097
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