(12 nodes) Vancomycin resistance network (Geosporobacter ferrireducens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	AOT68201.1	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
	murG	Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (376 aa)
	mraY	phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (321 aa)
	murF	Hypothetical protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (463 aa)
	AOT68633.1	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
	murF-2	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (470 aa)
	ddl	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (360 aa)
	ddl-2	D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (369 aa)
	AOT73127.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
	AOT71701.1	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (391 aa)
	AOT72437.1	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
	AOT72438.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (387 aa)

Your Current Organism:

Geosporobacter ferrireducens

NCBI taxonomy Id: 1424294
Other names: G. ferrireducens, Geosporobacter sp. IRF9, JCM 19987, KCTC 15395, strain IRF9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOT68201.1	AOT68633.1	Gferi_00530	Gferi_02880	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
AOT68201.1	AOT72437.1	Gferi_00530	Gferi_24530	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
AOT68201.1	AOT72438.1	Gferi_00530	Gferi_24535	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.930
AOT68633.1	AOT68201.1	Gferi_02880	Gferi_00530	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.963
AOT68633.1	AOT72437.1	Gferi_02880	Gferi_24530	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AOT68633.1	AOT72438.1	Gferi_02880	Gferi_24535	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.979
AOT68633.1	ddl	Gferi_02880	Gferi_02890	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.716
AOT68633.1	murF-2	Gferi_02880	Gferi_02885	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.	0.714
AOT71701.1	ddl	Gferi_20470	Gferi_02890	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.957
AOT71701.1	ddl-2	Gferi_20470	Gferi_11555	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	D-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.955
AOT71701.1	murF	Gferi_20470	Gferi_01970	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Hypothetical protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.	0.943
AOT71701.1	murF-2	Gferi_20470	Gferi_02885	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.	0.925
AOT71701.1	murG	Gferi_20470	Gferi_01950	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.	0.519
AOT72437.1	AOT68201.1	Gferi_24530	Gferi_00530	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
AOT72437.1	AOT68633.1	Gferi_24530	Gferi_02880	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AOT72437.1	AOT72438.1	Gferi_24530	Gferi_24535	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.996
AOT72438.1	AOT68201.1	Gferi_24535	Gferi_00530	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AOT72438.1	AOT68633.1	Gferi_24535	Gferi_02880	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
AOT72438.1	AOT72437.1	Gferi_24535	Gferi_24530	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA-binding response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AOT73127.1	ddl	Gferi_14015	Gferi_02890	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.514