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| | uvrA | UvrABC system protein A (UvrA protein)(Excinuclease ABC subunit A)(Excinuclease ATPase subunit); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa) |
| | ftsH | ATP-dependent zinc metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (640 aa) |
| | ruvB | Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (347 aa) |
| | ruvA | Holliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (209 aa) |
| | ftsZ-like | ftsZ-like; Required for synthesis of single-domain magnetite particles and magnetosomes, especially in the absence of nitrate. Forms filaments, which form bundles in the presence of GTP. Has both GTPase and ATPase activity; GTPase is 2.5 time more efficient. Has no activity on CTP or TTP. May be involved in redox control for magnetite crystallization (Probable). Mild overexpression causes cell elongation. May recruit other proteins (MamX, MamY and MamZ and possibly Mms6) to a complex required for biomineralization (Probable); Belongs to the FtsZ family. (311 aa) |
| | CDK99540.1 | Protein of unknown function; No homology to any previously reported sequences. (74 aa) |
| | mamK | Magnetosome cytoskeleton protein MamK; Protein with ATPase activity which forms dynamic cytoplasmic filaments that are involved in sorting, concatenating and/or correctly positioning of magnetosomes in the cell. Not absolutely necessary for assembly of short chains. Filaments grow from the both cell poles towards midcell, and are probably disassembled at the other end of the cell, a process known as treadmilling. Polymerizes in the presence of ATP, GTP or a non-hydrolyzable ATP analog. Required for correct segregation and positioning of magnetosomes following cell division. Belongs to [...] (347 aa) |
| | mutL | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (603 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity). Mild overexpression impairs cell division, leading to very elongated cells. Isolated protein forms filaments and bundles in the presence of GTP. (562 aa) |
| | Nudt | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (141 aa) |
| | CDK99753.1 | Bacteriophage tail assembly protein; Function of homologous gene experimentally demonstrated in an other organism; structure. (639 aa) |
| | yloB | P-type calcium transport ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (906 aa) |
| | CDK99827.1 | Large terminase protein; Function of homologous gene experimentally demonstrated in an other organism; structure. (661 aa) |
| | argK | Putative LAO/AO transport system kinase, argK family; Function of homologous gene experimentally demonstrated in an other organism; transporter. (327 aa) |
| | lepA | GTP-binding membrane protein,ribosomal elongation factor, GTPase; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (643 aa) |
| | ychF | Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa) |
| | uvrB | Excinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] (703 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | nudH | (Di)nucleoside polyphosphate hydrolase (Invasion protein A)(Nudix family); Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (165 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | yggV | Inosine/xanthosine triphosphate pyrophosphatase (subunit A); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa) |
| | CDL00163.1 | Nitrogen fixation protein fixI; Function of strongly homologous gene; enzyme. (779 aa) |
| | nudG | Pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase; Function of strongly homologous gene; enzyme; Belongs to the Nudix hydrolase family. (334 aa) |
| | rppH | RNA pyrophosphohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the Nudix hydrolase family. (157 aa) |
| | htpG | Molecular chaperone HSP90 family(High temperature protein G); Molecular chaperone. Has ATPase activity. (621 aa) |
| | ycaJ | Putative polynucleotide enzyme with nucleotide triphosphate hydrolase domain; Function of homologous gene experimentally demonstrated in an other organism; cell process. (430 aa) |
| | bipA | GTP-binding protein; Function of homologous gene experimentally demonstrated in an other organism; factor. (609 aa) |
| | ppa | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (178 aa) |
| | CDL00526.1 | Putative maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (196 aa) |
| | mnmE | tRNA modification GTPase mnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (435 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (106 aa) |
| | hslU | ATPase component of the HslUV protease, also functions as molecular chaperone; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (442 aa) |
| | CDL00723.1 | Homologs of previously reported genes of unknown function. (281 aa) |
| | yloB-2 | Calcium-transporting ATPase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (883 aa) |
| | ffh | Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex [...] (455 aa) |
| | clpA | ATP-dependent specificity subunit of clpA-clpP serine protease; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ClpA/ClpB family. (764 aa) |
| | ftsY | Signal recognition particle (docking protein); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (357 aa) |
| | CDL00839.1 | Flagellar biosynthesis protein; Function of strongly homologous gene; structure. (333 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (887 aa) |
| | uppP1 | Undecaprenyl-diphosphatase 1; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP); Belongs to the UppP family. (266 aa) |
| | clpB | Chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (862 aa) |
| | uvrD | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (745 aa) |
| | CDL01194.1 | Putative cation transport ATPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (704 aa) |
| | CDL01195.1 | Homologs of previously reported genes of unknown function. (111 aa) |
| | CDL01232.1 | Putative exopolyphosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (331 aa) |
| | fusA-3 | Elongation factor G (EF-G); Function of homologous gene experimentally demonstrated in an other organism; factor. (677 aa) |
| | cobS-2 | Aerobic cobaltochelatase cobS subunit (cobalamin biosynthesis); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (347 aa) |
| | fliI | Flagellum-specific ATP synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (450 aa) |
| | CDL01376.1 | Homologs of previously reported genes of unknown function. (90 aa) |
| | clpX | ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (421 aa) |
| | lon | DNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (800 aa) |
| | CDK98409.1 | Homologs of previously reported genes of unknown function. (272 aa) |
| | hppA | K(+)-insensitive pyrophosphate-energized proton pump; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. (693 aa) |
| | hflX | Putative GTP-binding protein (hflX); GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (422 aa) |
| | mazG | Protein mazG; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (265 aa) |
| | era | GTP-binding protein (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (303 aa) |
| | CDK98258.1 | Putative segregation and condensation protein B homolog; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (220 aa) |
| | copA | Copper transporter ATPase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (801 aa) |
| | fusA | Elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (715 aa) |
| | tufB | Elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa) |
| | fusA-2 | Elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (694 aa) |
| | tufB-2 | Elongation factor Tu (EF-Tu); Function of homologous gene experimentally demonstrated in an other organism; factor. (396 aa) |
| | CDK97287.1 | Homologs of previously reported genes of unknown function. (216 aa) |
| | CDK97472.1 | ATPase, P-type, heavy metal translocating; Function of strongly homologous gene; enzyme. (803 aa) |
| | CDK97594.1 | Putative septum formation protein (Maf-like protein); Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | cysC-2 | Adenylylsulphate kinase; Catalyzes the synthesis of activated sulfate. (621 aa) |
| | CDK97725.1 | Putative periplasmic protein kinase ArgK; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (307 aa) |
| | CDK98570.1 | Homologs of previously reported genes of unknown function. (160 aa) |
| | CDK98674.1 | Conserved Iron-sulfur protein of unknown function; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (372 aa) |
| | dnaB | Replicative DNA helicase, dnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (497 aa) |
| | cpaE | Pilus assembly protein cpaE; Function of strongly homologous gene; transporter. (395 aa) |
| | CDK98872.1 | ATPase, P-type (Transporting), HAD superfamily, subfamily IC; Function of strongly homologous gene; enzyme. (882 aa) |
| | bacA | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (265 aa) |
| | norQ | Protein norQ; Function of strongly homologous gene; factor. (260 aa) |
| | CDK97897.1 | Putative large terminase protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (653 aa) |
| | obgE | GTPase involved in cell partioning and DNA repair; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (423 aa) |
| | kdpB | Potassium transport system P-type ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (680 aa) |
| | CDK99121.1 | Protein of unknown function; No homology to any previously reported sequences. (156 aa) |
| | CDK99188.1 | Putative Phage/plasmid primase P4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (896 aa) |
| | CDK99190.1 | Putative Large terminase protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (617 aa) |
| | CDK99202.1 | Putative adenylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (503 aa) |
| | CDK99223.1 | Putative NADH pyrophosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the Nudix hydrolase family. (310 aa) |
| | ureG | Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. (205 aa) |
| | arsA | Arsenical pump-driving ATPase; Anion-transporting ATPase; Belongs to the arsA ATPase family. (568 aa) |
| | hypB | Hydrogenase nickel incorporation protein hypB; Function of homologous gene experimentally demonstrated in an other organism; cell process. (299 aa) |
| | CDK99427.1 | AFG1-like ATPase; Function of strongly homologous gene; enzyme. (384 aa) |
| | CDK99446.1 | Putative NUDIX hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (208 aa) |
| | CDK99448.1 | ATPase associated with various cellular activities; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (331 aa) |
| | smc | Putative chromosome segregation SMC protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1155 aa) |
| | prfC | Peptide chain release factor RF-3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (528 aa) |
