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| | CDK98680.1 | Putative propionyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (637 aa) |
| | rpoD | Sigma D (sigma 70) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (664 aa) |
| | folD | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa) |
| | pyrD | Dihydro-orotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa) |
| | tgt | tRNA-guanine transglycosylase (queuine/archaeosine tRNA-ribosyltransferase); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophil [...] (376 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (345 aa) |
| | CDL00123.1 | Putative oxygen-independent coproporphyrinogen III oxidase (yggW); Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa) |
| | dfp | Fused 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | moeB | Molybdopterin synthase sulfurylase; Function of strongly homologous gene; enzyme. (266 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (396 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | mtnP | Putative S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (291 aa) |
| | CDL00039.1 | Putative oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (172 aa) |
| | prsA | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (308 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B; Function of strongly homologous gene; factor. (164 aa) |
| | moeA | Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (409 aa) |
| | moaD | Molybdopterin synthase, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (83 aa) |
| | moaE | Molybdenum cofactor biosynthesis protein E; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (154 aa) |
| | cbiD | Putative cobalt-precorrin-6A synthase, cbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (366 aa) |
| | cobK | Precorrin-6A reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (247 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (645 aa) |
| | sigK | Putative RNA polymerase sigma factor sigK; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | CDK99992.1 | Homologs of previously reported genes of unknown function. (138 aa) |
| | folE | GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (203 aa) |
| | ribF | Riboflavin biosynthesis protein ribF; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribF family. (331 aa) |
| | ctaA | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (339 aa) |
| | mogA | Molybdochelatase MogA, involved in Moco biosynthesis; Function of homologous gene experimentally demonstrated in an other organism; factor. (178 aa) |
| | dnaX | DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (586 aa) |
| | CDK99823.1 | Homologs of previously reported genes of unknown function. (192 aa) |
| | murD | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (463 aa) |
| | rpoE | RNA polymerase sigma-70 factor, ECF family protein; Function of homologous gene experimentally demonstrated in an other organism; factor; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | trpB-2 | Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | CDK99661.1 | DNA primase traC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (776 aa) |
| | umuC-2 | DNA polymerase V, subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (425 aa) |
| | atpB-2 | ATP synthase subunit A, membrane-bound, F0 sector; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (244 aa) |
| | atpE | ATP synthase subunit C, membrane-bound, F0 sector; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpB | ATP synthase subunit B', membrane-bound, F0 sector; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa) |
| | atpF | ATP synthase subunit B, membrane-bound, F0 sector; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (176 aa) |
| | pdxY | Pyridoxamine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyridoxine kinase family. (275 aa) |
| | CDK99354.1 | Putative GTPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (345 aa) |
| | glmU | Bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa) |
| | CDK99321.1 | Putative RNA polymerase sigma factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the sigma-70 factor family. (291 aa) |
| | CDK99316.1 | Putative cob(II)yrinic acid a,c-diamide reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (251 aa) |
| | CDK99293.1 | Putative DNA polymerase III; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (459 aa) |
| | CDK99269.1 | Putative polynucleotidyl transferase, ribonuclease H fold; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (619 aa) |
| | purS | Factor required for phosphoribosylformylglycinamidine synthetase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ [...] (79 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase); Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (254 aa) |
| | purB | Adenylosuccinate lyase (Adenylosuccinase) (ASL); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (445 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (552 aa) |
| | napA | Periplasmic nitrate reductase, large subunit (NapA); Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (835 aa) |
| | CDK99188.1 | Putative Phage/plasmid primase P4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (896 aa) |
| | CDK99155.1 | DNA primase TraC; Function of strongly homologous gene; enzyme. (702 aa) |
| | umuC | DNA polymerase V, subunit C; Function of strongly homologous gene; enzyme. (338 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | gmk | Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (216 aa) |
| | CDK99068.1 | Putative Acetyl-coenzyme A synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (549 aa) |
| | rfaE | Fused heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (488 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (152 aa) |
| | queG | Conserved protein of unknown function,containing iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (341 aa) |
| | nadB | Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | nadC | Quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase); Function of strongly homologous gene; enzyme; Belongs to the NadC/ModD family. (283 aa) |
| | nadA | Quinolinate synthase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (339 aa) |
| | cbiM | Cobalamin (vitamin B12) biosynthesis CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (215 aa) |
| | cbiN | Cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (91 aa) |
| | CDK98988.1 | Putative Cobalt transport permease subunit CbiQ; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (241 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | proA | Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | nadD | Putative nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (202 aa) |
| | CDK98968.1 | Putative formate dehydrogenase formation protein FdhD; Required for formate dehydrogenase (FDH) activity. Belongs to the FdhD family. (276 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | accD | acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa) |
| | CDK98959.1 | Dihydrofolate synthase / folylpolyglutamate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the folylpolyglutamate synthase family. (434 aa) |
| | thiD | Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (267 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (588 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (229 aa) |
| | purL | Phosphoribosylformylglycinamidine synthetase II, PurM N-terminal domain-like; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...] (732 aa) |
| | CDK98779.1 | Protein BolA homolog; Function of strongly homologous gene; regulator; Belongs to the BolA/IbaG family. (85 aa) |
| | CDK98764.1 | Putative UDP-glucose epimerase, containing with NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (326 aa) |
| | CDK98756.1 | Adenylate/guanylate cyclase; Function of strongly homologous gene; putative enzyme. (703 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (229 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa) |
| | dnaB | Replicative DNA helicase, dnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (497 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit (AIR carboxylase) (AIRC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (370 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | CDK98614.1 | Putative Tetrapyrrole methylase（putative nirE） Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the precorrin methyltransferase family. (253 aa) |
| | nirD | Protein nirD; Function of strongly homologous gene; enzyme. (149 aa) |
| | nirL | Protein nirL; Function of strongly homologous gene; regulator. (165 aa) |
| | nirG | Protein nirG; Function of strongly homologous gene; enzyme. (148 aa) |
| | nirH | Protein nirH; Function of strongly homologous gene; enzyme. (161 aa) |
| | CDK98607.1 | Putative Coenzyme PQQ synthesis protein E (putative nirJ); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (375 aa) |
| | CDK98606.1 | Homologs of previously reported genes of unknown function. (555 aa) |
| | CDK98570.1 | Homologs of previously reported genes of unknown function. (160 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (260 aa) |
| | CDK98522.1 | Putative dihydroorotate dehydrogenase(electron transfer subunit); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (278 aa) |
| | CDK98519.1 | Conserved protein of unknown function,containing radical SAM; Homologs of previously reported genes of unknown function. (316 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa) |
| | pyrH | Uridylate kinase (UK) (Uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | ribD | Bifunctional: diaminohydroxyphosphoribosylaminopyrimidine deaminase (N-terminal); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa) |
| | ribC | Riboflavin synthase alpha chain; Function of strongly homologous gene; enzyme. (197 aa) |
| | ribBA | Riboflavin biosynthesis protein ribBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (371 aa) |
| | ribH | Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (144 aa) |
| | nusB | Transcription antitermination factor (L factor) (N utilization substance protein B); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (160 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (347 aa) |
| | pncB | Nicotinate phosphoribosyltransferase (NAPRTase); Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (432 aa) |
| | CDK98345.1 | Putative DNA polymerase III, delta prime subunit（ATPase involved in DNA replication） Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (359 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (334 aa) |
| | dnaE | DNA polymerase III, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1159 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ (PNP synthase); Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (246 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (128 aa) |
| | porC | Pyruvate synthase subunit porC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (188 aa) |
| | porA | Pyruvate synthase subunit porA; Function of strongly homologous gene; enzyme. (387 aa) |
| | porB | Pyruvate synthase subunit porB; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (327 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (199 aa) |
| | serS | seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (420 aa) |
| | CDK98238.1 | Homologs of previously reported genes of unknown function; Belongs to the CinA family. (161 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (417 aa) |
| | CDK98233.1 | Putative phosphate acetyltransferase containing a MaoC like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (469 aa) |
| | CDK98226.1 | Binuclear zinc phosphodiesterase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (275 aa) |
| | kdtB | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (170 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (357 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (457 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (333 aa) |
| | pyrG | CTP synthase (UTP--ammonia ligase) (CTP synthetase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (541 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (506 aa) |
| | rpoH-2 | Sigma H (sigma 32) factor of RNA polymerase; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (290 aa) |
| | bioB | Biotin synthetase (Biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (324 aa) |
| | CDK98146.1 | Putative 8-amino-7-oxononanoate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (392 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (216 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa) |
| | CDK98127.1 | Putative Adenylate/guanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (595 aa) |
| | CDK98121.1 | Uroporphyrinogen III synthase HEM4 (modular protein); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (243 aa) |
| | HEMC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa) |
| | cobU | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (168 aa) |
| | CDK98114.1 | Putative cobalamin synthesis protein cobW; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (334 aa) |
| | cobN | Aerobic cobaltochelatase subunit CobN; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1216 aa) |
| | CDK98101.1 | Molybdopterin biosynthesis protein; Function of strongly homologous gene; enzyme. (483 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (347 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase (IGPS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. (267 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (158 aa) |
| | hemN | Oxygen-independent coproporphyrinogen-III oxidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (449 aa) |
| | CDK98011.1 | Putative Molybdopterin-guanine dinucleotide biosynthesis protein B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (191 aa) |
| | CDK98006.1 | Putative DNA polymerase III subunit epsilon-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (677 aa) |
| | folP | Dihydropteroate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (378 aa) |
| | CDK97986.1 | Putative RNA polymerase sigma factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the sigma-70 factor family. ECF subfamily. (183 aa) |
| | CDK97983.1 | Homologs of previously reported genes of unknown function; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (200 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (210 aa) |
| | CDK97970.1 | Homologs of previously reported genes of unknown function. (211 aa) |
| | CDK97969.1 | Homologs of previously reported genes of unknown function. (569 aa) |
| | CDK97948.1 | Putative Adenylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (765 aa) |
| | CDK97900.1 | Homologs of previously reported genes of unknown function. (91 aa) |
| | CDK97808.1 | Putative radical SAM domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (501 aa) |
| | rpoH | RNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (288 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (327 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | CDK97719.1 | Putative dihydroorotase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (444 aa) |
| | folK | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase(HPPK); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (165 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (410 aa) |
| | nifH | Nitrogenase iron protein, nifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (293 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (432 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (184 aa) |
| | CDK97515.1 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (456 aa) |
| | hemA | Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (411 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (434 aa) |
| | pyrB | Aspartate carbamoyltransferase; Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (316 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa) |
| | CDK97436.1 | Putative von Willebrand factor, type A; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (484 aa) |
| | CDK97393.1 | Putative molybdenum utilization protein ModD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the NadC/ModD family. (276 aa) |
| | cobC | Threonine-phosphate decarboxylase; Function of strongly homologous gene; enzyme. (324 aa) |
| | CDK97322.1 | Putative RNA polymerase sigma factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | CDK97319.1 | Putative RNA polymerase ECF-type sigma factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the sigma-70 factor family. ECF subfamily. (203 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (605 aa) |
| | rpoA | DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1495 aa) |
| | rpoB | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1393 aa) |
| | nusG | Component in transcription antitermination; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | CDK97228.1 | Protein of unknown function; No homology to any previously reported sequences. (599 aa) |
| | dnaN | DNA polymerase III, beta-subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | CDL01183.1 | Homologs of previously reported genes of unknown function. (229 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase); Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (336 aa) |
| | holC | DNA polymerase III subunit chi; Function of strongly homologous gene; enzyme. (151 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (195 aa) |
| | cobB-2 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (463 aa) |
| | CDL01275.1 | Putative phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (339 aa) |
| | CDL01278.1 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | cobT-2 | Aerobic cobaltochelatase cobT subunit (cobalamin biosynthesis); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (636 aa) |
| | bolA | Regulator of penicillin binding proteins and beta lactamase transcription (morphogene); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the BolA/IbaG family. (96 aa) |
| | fliI | Flagellum-specific ATP synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (450 aa) |
| | CDL01309.1 | Homologs of previously reported genes of unknown function. (96 aa) |
| | CDL01340.1 | Putative RNA-directed DNA polymerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (308 aa) |
| | dinB | DNA polymerase IV, devoid of proofreading, damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (386 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa) |
| | CDL01362.1 | Putative Phosphoribulokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (318 aa) |
| | CDL01390.1 | Putative NAD-dependent epimerase/dehydratase(UDP-glucose 4-epimerase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (314 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (165 aa) |
| | CDL01397.1 | Putative Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (672 aa) |
| | CDL01398.1 | Putative GDP-L-fucose synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (320 aa) |
| | CDL01409.1 | Conserved protein of unknown function(Radical SAM domain); Homologs of previously reported genes of unknown function. (522 aa) |
| | CDL01410.1 | Homologs of previously reported genes of unknown function. (260 aa) |
| | CDL01415.1 | Conserved protein of unknown function(Radical SAM domain protein domain); Homologs of previously reported genes of unknown function. (442 aa) |
| | ctaB | Putative Protoheme IX farnesyltransferase 1; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (284 aa) |
| | CDL01171.1 | Putative adenylate/guanylate cyclase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (662 aa) |
| | yvqK | ATP:cob(I)alamin adenosyltransferase; Function of strongly homologous gene; enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. (188 aa) |
| | pabB | Aminodeoxychorismate synthase, subunit I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (441 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase; Function of strongly homologous gene; enzyme. (269 aa) |
| | acs | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa) |
| | queE | Putative 7-carboxy-7-deazaguanine synthase homolog; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa) |
| | CDL01132.1 | Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (176 aa) |
| | atpC | F1 sector of membrane-bound ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | atpD | ATP synthase subunit beta, membrane-bound, F1 sector; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (474 aa) |
| | atpG | ATP synthase subunit gamma, membrane-bound, F1 sector; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (293 aa) |
| | atpA | F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa) |
| | priA | Primosomal protein N' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (732 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (248 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (212 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | cmk | Cytidylate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (211 aa) |
| | CDL01038.1 | Homologs of previously reported genes of unknown function. (163 aa) |
| | CDL00985.1 | Protein of unknown function; No homology to any previously reported sequences. (143 aa) |
| | hemA-2 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa) |
| | CDL00951.1 | Homologs of previously reported genes of unknown function. (255 aa) |
| | CDL00950.1 | Putative Uroporphyrinogen-III methylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the precorrin methyltransferase family. (258 aa) |
| | CDL00946.1 | Putative Adenylate cyclase 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (685 aa) |
| | rkpK | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (434 aa) |
| | nusA | Transcription elongation protein nusA (N utilization substance protein A) (L factor); Participates in both transcription termination and antitermination. (503 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (427 aa) |
| | queC | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (230 aa) |
| | CDL00805.1 | Putative exonucleases; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (173 aa) |
| | apaG | ApaG protein; Function of strongly homologous gene; transporter. (130 aa) |
| | folE-2 | GTP cyclohydrolase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (220 aa) |
| | CDL00764.1 | Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (316 aa) |
| | CDL00753.1 | Putative Phenylacetic acid-responsive transcriptional repressor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. (327 aa) |
| | CDL00747.1 | Homologs of previously reported genes of unknown function. (342 aa) |
| | thyX | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (311 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (336 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa) |
| | ribA | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. (376 aa) |
| | CDL00696.1 | Putative Thiamine monophosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (202 aa) |
| | galE | UDP-glucose 4-epimerase; Function of strongly homologous gene; enzyme. (314 aa) |
| | CDL00651.1 | Putative 3-deoxy-D-manno-octulosonate cytidylyltransferase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family. (514 aa) |
| | CDL00640.1 | Putative Fe-S oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (515 aa) |
| | CDL00636.1 | Protein of unknown function; No homology to any previously reported sequences. (711 aa) |
| | CDL00621.1 | Homologs of previously reported genes of unknown function. (376 aa) |
| | rfbG | CDP-glucose 4,6-dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (368 aa) |
| | CDL00612.1 | Putative nucleotide sugar epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (148 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (526 aa) |
| | CDL00591.1 | Putative NAD-dependent epimerase/dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (353 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (328 aa) |
| | nadK | Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa) |
| | CDL00530.1 | Homologs of previously reported genes of unknown function. (144 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (329 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (345 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (213 aa) |
| | dnaQ | DNA polymerase III: epsilon subunit, 3-5 exonucleolytic proofreading function; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (228 aa) |
| | cobO | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (202 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (495 aa) |
| | cobD | Cobalamin biosynthetic protein (anaerobic pathway of cobalamin biosynthesis, cobD); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (335 aa) |
| | CDL00447.1 | Putative sirohydrochlorin cobaltochelatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa) |
| | CDL00446.1 | Homologs of previously reported genes of unknown function. (504 aa) |
| | cobL | Precorrin-6Y C(5,15)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (392 aa) |
| | cobI | Precorrin-2 C(20)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. (226 aa) |
| | cobJ | Precorrin-3B methylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (594 aa) |
| | cobM | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (253 aa) |
| | cobA | Uroporphyrinogen-III C-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. (260 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (438 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. (151 aa) |
| | polA | Fused DNA polymerase I 5'->3' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (925 aa) |
| | accA | acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1083 aa) |
| | carA | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit glutamine amidotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (393 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (627 aa) |
