STRINGSTRING
sucD sucD sucC sucC AHG73210.1 AHG73210.1 AHG73211.1 AHG73211.1 leuB leuB AHG73324.1 AHG73324.1 accD accD AHG73344.1 AHG73344.1 AHG73359.1 AHG73359.1 AHG73360.1 AHG73360.1 AHG73361.1 AHG73361.1 ackA ackA AHG73371.1 AHG73371.1 AHG73373.1 AHG73373.1 AHG73374.1 AHG73374.1 AHG73534.1 AHG73534.1 AHG73535.1 AHG73535.1 AHG73536.1 AHG73536.1 pckA pckA AHG73643.1 AHG73643.1 leuA leuA ppc ppc eno eno AHG73923.1 AHG73923.1 AHG73973.1 AHG73973.1 mdh mdh oadG oadG AHG74054.1 AHG74054.1 AHG74055.1 AHG74055.1 AHG74096.1 AHG74096.1 ilvA ilvA accA accA AHG74334.1 AHG74334.1 AHG74376.1 AHG74376.1 AHG74377.1 AHG74377.1 fumC fumC frdD frdD frdC frdC AHG74425.1 AHG74425.1 AHG74426.1 AHG74426.1 AHG74476.1 AHG74476.1 X781_280 X781_280 X781_290 X781_290 ilvC ilvC leuD leuD leuC leuC X781_4600 X781_4600 X781_4930 X781_4930 X781_4940 X781_4940 X781_5640 X781_5640 X781_5750 X781_5750 X781_5930 X781_5930 dld dld X781_7370 X781_7370 ilvD ilvD X781_7880 X781_7880 X781_7890 X781_7890 X781_7900 X781_7900 X781_7910 X781_7910 X781_7920 X781_7920
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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sucDSuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
sucCSuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
AHG73210.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
AHG73211.12-oxoglutarate dehydrogenase E1 component PRK09404; 2-oxoglutarate dehydrogenase E1 component of Gammaproteobacteria UniRef RepID=B3GX32_ACTP7. (936 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
AHG73324.1Glutamate dehydrogenase PRK09414; Glutamate dehydrogenase of Proteobacteria UniRef RepID=Q46UV2_CUPPJ; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa)
accDAcetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa)
AHG73344.1Aromatic amino acid aminotransferase PRK09257; Aspartate aminotransferase of Proteobacteria UniRef RepID=AAT_HAEIN. (398 aa)
AHG73359.1Type II citrate synthase PRK05614; Citrate synthase I of Bacteria UniRef RepID=E3I1M6_RHOVT; Belongs to the citrate synthase family. (426 aa)
AHG73360.1Isocitrate dehydrogenase PRK07006; Isocitrate dehydrogenase [NADP] of Gammaproteobacteria UniRef RepID=B7UV18_PSEA8. (415 aa)
AHG73361.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase PRK09238; Aconitate hydratase 2 of cellular organisms UniRef RepID=ACON2_PSEAE; Belongs to the aconitase/IPM isomerase family. (868 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
AHG73371.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (711 aa)
AHG73373.1Acetolactate synthase 3 catalytic subunit PRK06882; Acetolactate synthase isozyme 3 large subunit of Proteobacteria UniRef RepID=ILVI_ECOLI. (577 aa)
AHG73374.1Acetolactate synthase 3 regulatory subunit PRK11895; Acetolactate synthase small subunit of root UniRef RepID=ILVH_HAEIN. (163 aa)
AHG73534.1Dihydrolipoamide dehydrogenase PRK06467; Dihydrolipoyl dehydrogenase of cellular organisms UniRef RepID=DLDH_HAEIN. (474 aa)
AHG73535.1Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (633 aa)
AHG73536.1Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (885 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (535 aa)
AHG73643.1Aspartate oxidase COG0029; Possible aspartate oxidase of Pasteurellaceae UniRef RepID=A7JWJ6_PASHA. (528 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (866 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (436 aa)
AHG73923.1Pyruvate kinase PRK05826; Pyruvate kinase of root UniRef RepID=KPYK_HAEIN; Belongs to the pyruvate kinase family. (466 aa)
AHG73973.1Bifunctional malic enzyme oxidoreductase/phosphotransacetylase PRK07232; NADP-dependent malic enzyme of Bacteria UniRef RepID=MAO2_SALTY. (756 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (320 aa)
oadGOxaloacetate decarboxylase gamma chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (70 aa)
AHG74054.1Oxaloacetate decarboxylase PRK14040; Oxaloacetate decarboxylase alpha chain of cellular organisms UniRef RepID=DCOA_KLEPN. (601 aa)
AHG74055.1Oxaloacetate decarboxylase beta chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (434 aa)
AHG74096.1Ferredoxin PRK07118; Ferredoxin of root UniRef RepID=Q7VP07_HAEDU. (73 aa)
ilvAThreonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (509 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (329 aa)
AHG74334.1UPF0350 protein; Uncharacterized conserved protein COG2938; UPF0350 protein HD_0065 of Pasteurellaceae UniRef RepID=Y065_HAEDU. (82 aa)
AHG74376.1Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa)
AHG74377.1Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
frdDReductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (115 aa)
frdCReductase; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (130 aa)
AHG74425.1Fumarate reductase iron-sulfur subunit PRK12385; Fumarate reductase iron-sulfur subunit of Proteobacteria UniRef RepID=FRDB_HAEIN; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (243 aa)
AHG74426.1Fumarate reductase flavoprotein subunit PRK09231; Fumarate reductase flavoprotein subunit of cellular organisms UniRef RepID=FRDA_HAEIN. (600 aa)
AHG74476.12-hydroxy-3-oxopropionate reductase; 3-hydroxyisobutyrate dehydrogenase and beta-hydroxyacid dehydrogenases COG2084; 2-hydroxy-3-oxopropionate reductase of Pasteurellaceae UniRef RepID=A6VLT0_ACTSZ. (289 aa)
X781_280Aldehyde dehydrogenase A PRK10090; Aldehyde Dehydrogenase of cellular organisms UniRef RepID=D0KD90_PECWW; Belongs to the aldehyde dehydrogenase family. (482 aa)
X781_290L-1,2-propanediol oxidoreductase PRK10624; Lactaldehyde reductase of Bacteria UniRef RepID=A6LQL3_CLOB8. (383 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa)
leuD3-isopropylmalate dehydratase large subunit-like protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuC3-isopropylmalate dehydratase large subunit-like protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
X781_4600Acylphosphatase PRK14448; Acylphosphatase of Haemophilus pittmaniae HK 85 UniRef RepID=F9QC67_9PAST. (79 aa)
X781_4930Acetolactate synthase 2 regulatory subunit PRK11152; Acetolactate synthase isozyme II small subunit (AHAS-II) of Actinobacillus UniRef RepID=A3MYH0_ACTP2. (72 aa)
X781_4940Acetolactate synthase 2 catalytic subunit PRK08978; Acetolactate synthase isozyme 2 large subunit of cellular organisms UniRef RepID=ILVG_ECOLI. (550 aa)
X781_5640Formate acetyltransferase of cellular organisms UniRef RepID=PFLB_HAEIN. (774 aa)
X781_5750Branched-chain amino acid aminotransferase PRK13357; Branched-chain-amino-acid aminotransferase of cellular organisms UniRef RepID=ILVE_HAEIN. (345 aa)
X781_5930Aminotransferase AlaT PRK09265; Aminotransferase AlaT of Bacteria UniRef RepID=B8F699_HAEPS. (405 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (563 aa)
X781_7370Bifunctional acetaldehyde-CoA/alcohol dehydrogenase PRK13805; Iron-containing alcohol dehydrogenase of Bacteria UniRef RepID=C7QZE3_JONDD; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (870 aa)
ilvDDihydroxy-acid dehydratase PRK12448; Dihydroxy-acid dehydratase of root UniRef RepID=ILVD_NEIG1; Belongs to the IlvD/Edd family. (643 aa)
X781_7880Citrate transporter; H+/gluconate symporter and permeases COG2610; Citrate transporter of Bacteria UniRef RepID=A8MFL8_ALKOO. (441 aa)
X781_7890D-beta-hydroxybutyrate dehydrogenase of Bacteria UniRef RepID=Q08MV7_STIAD. (252 aa)
X781_7900Acyltransferase PRK05790; Acetyl-CoA acetyltransferase of cellular organisms UniRef RepID=THIL_CUPNH; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
X781_7910Acetate CoA-transferase subunit beta of Bacteria UniRef RepID=ATOA_HAEIN. (219 aa)
X781_7920acetyl-CoA:acetoacetyl-CoA transferase subunit alpha PRK09920; Acetate CoA-transferase subunit alpha of Bacteria UniRef RepID=ATOD_HAEIN. (195 aa)
Your Current Organism:
Mannheimia sp. USDAARSUSMARC1261
NCBI taxonomy Id: 1432056
Other names: M. sp. USDA-ARS-USMARC-1261, Mannheimia sp. USDA-ARS-USMARC-1261
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