(5 nodes) DNA synthesis, and dTTP metabolic process network (Thermococcus guaymasensis)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	tmk	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
	AJC71766.1	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1063 aa)
	tdk	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
	thyX	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (248 aa)
	AJC72252.1	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)

Your Current Organism:

Thermococcus guaymasensis

NCBI taxonomy Id: 1432656
Other names: T. guaymasensis DSM 11113, Thermococcus guaymasensis DSM 11113

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJC71766.1	tdk	X802_06045	X802_07675	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.561
AJC71766.1	thyX	X802_06045	X802_08040	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.417
AJC71766.1	tmk	X802_06045	X802_01815	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
AJC72252.1	tdk	X802_08955	X802_07675	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.937
AJC72252.1	thyX	X802_08955	X802_08040	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.930
AJC72252.1	tmk	X802_08955	X802_01815	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.953
tdk	AJC71766.1	X802_07675	X802_06045	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.561
tdk	AJC72252.1	X802_07675	X802_08955	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.937
tdk	thyX	X802_07675	X802_08040	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.929
tdk	tmk	X802_07675	X802_01815	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
thyX	AJC71766.1	X802_08040	X802_06045	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.417
thyX	AJC72252.1	X802_08040	X802_08955	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
thyX	tdk	X802_08040	X802_07675	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
thyX	tmk	X802_08040	X802_01815	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.946
tmk	AJC71766.1	X802_01815	X802_06045	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator SirA; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.	0.972
tmk	AJC72252.1	X802_01815	X802_08955	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	dCMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.953
tmk	tdk	X802_01815	X802_07675	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
tmk	thyX	X802_01815	X802_08040	Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.946