STRINGSTRING
AKB23506.1 AKB23506.1 argB argB ilvE ilvE AKB23767.1 AKB23767.1 AKB23803.1 AKB23803.1 AKB23804.1 AKB23804.1 cimA cimA AKB24176.1 AKB24176.1 AKB24177.1 AKB24177.1 ilvC ilvC hacB hacB AKB24203.1 AKB24203.1 ilvD ilvD AKB24559.1 AKB24559.1 leuD leuD leuC leuC AKB24832.1 AKB24832.1 AKB25036.1 AKB25036.1 AKB25617.1 AKB25617.1 AKB25648.1 AKB25648.1 leuC-2 leuC-2 leuC-3 leuC-3 argJ argJ argC argC AKB26419.1 AKB26419.1 AKB26505.1 AKB26505.1 AKB26506.1 AKB26506.1 AKB26507.1 AKB26507.1 AKB26521.1 AKB26521.1 leuD-2 leuD-2 AKB26609.1 AKB26609.1 argD argD
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AKB23506.12-isopropylmalate synthase. (458 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
AKB23767.1N-acetylglutamate synthase. (151 aa)
AKB23803.13-isopropylmalate dehydrogenase. (342 aa)
AKB23804.12-isopropylmalate synthase. (431 aa)
cimA(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (465 aa)
AKB24176.1Acetolactate synthase large subunit. (562 aa)
AKB24177.1Acetolactate synthase small subunit. (161 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
hacBCoenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (168 aa)
AKB24203.1Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
AKB24559.1Aspartate aminotransferase. (380 aa)
leuDAconitate hydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (172 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (417 aa)
AKB24832.1Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10. (405 aa)
AKB25036.1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (570 aa)
AKB25617.1Acetolactate synthase; Belongs to the TPP enzyme family. (544 aa)
AKB25648.1Biosynthetic Aromatic amino acid aminotransferase alpha / Aspartate aminotransferase. (370 aa)
leuC-23-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa)
leuC-3Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (336 aa)
AKB26419.1Aspartate-semialdehyde dehydrogenase. (342 aa)
AKB26505.1Citrate synthase (si). (373 aa)
AKB26506.1Aconitate hydratase. (934 aa)
AKB26507.1Citrate synthase (si). (355 aa)
AKB26521.1N-acetylglutamate synthase. (121 aa)
leuD-23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
AKB26609.1Aspartokinase; Belongs to the aspartokinase family. (464 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa)
Your Current Organism:
Methanosarcina sp. MTP4
NCBI taxonomy Id: 1434100
Other names: M. sp. MTP4
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