(11 nodes) Ribulose-phosphate binding barrel network (Methanosarcina sp. WWM596)

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Your Input:
	AKB18782.1	D-arabino-3-hexulose 6-phosphate formaldehyde lyase; Hypothetical protein with distant similarity to Ribonuclease E inhibitor RraA (former MenG). (383 aa)
	fae-hps	Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (392 aa)
	hisA	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa)
	AKB17361.1	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (245 aa)
	pdxS	Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa)
	AKB18601.1	Peptidase, U32 family large subunit (C1). (862 aa)
	trpC	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (268 aa)
	trpA	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (275 aa)
	trpF	Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (234 aa)
	hisF	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa)
	pyrF	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (221 aa)

Your Current Organism:

Methanosarcina sp. WWM596

NCBI taxonomy Id: 1434103
Other names: M. sp. WWM596

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB17361.1	fae-hps	MSWHS_0498	MSWHS_0037	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.	0.527
AKB17361.1	hisA	MSWHS_0498	MSWHS_0153	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	0.930
AKB17361.1	hisF	MSWHS_0498	MSWHS_2372	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.937
AKB18782.1	fae-hps	MSWHS_1919	MSWHS_0037	D-arabino-3-hexulose 6-phosphate formaldehyde lyase; Hypothetical protein with distant similarity to Ribonuclease E inhibitor RraA (former MenG).	Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.	0.930
fae-hps	AKB17361.1	MSWHS_0037	MSWHS_0498	Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	0.527
fae-hps	AKB18782.1	MSWHS_0037	MSWHS_1919	Formaldehyde activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.	D-arabino-3-hexulose 6-phosphate formaldehyde lyase; Hypothetical protein with distant similarity to Ribonuclease E inhibitor RraA (former MenG).	0.930
hisA	AKB17361.1	MSWHS_0153	MSWHS_0498	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	0.930
hisA	hisF	MSWHS_0153	MSWHS_2372	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.999
hisA	trpA	MSWHS_0153	MSWHS_1875	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.570
hisA	trpC	MSWHS_0153	MSWHS_1873	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.593
hisA	trpF	MSWHS_0153	MSWHS_1877	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	Phosphoribosylanthranilate isomerase; Belongs to the TrpF family.	0.570
hisF	AKB17361.1	MSWHS_2372	MSWHS_0498	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family.	0.937
hisF	hisA	MSWHS_2372	MSWHS_0153	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.	0.999
hisF	pyrF	MSWHS_2372	MSWHS_2684	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.456
hisF	trpA	MSWHS_2372	MSWHS_1875	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.632
hisF	trpC	MSWHS_2372	MSWHS_1873	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.637
hisF	trpF	MSWHS_2372	MSWHS_1877	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	Phosphoribosylanthranilate isomerase; Belongs to the TrpF family.	0.633
pyrF	hisF	MSWHS_2684	MSWHS_2372	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.	0.456
pyrF	trpA	MSWHS_2684	MSWHS_1875	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.580
pyrF	trpC	MSWHS_2684	MSWHS_1873	Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.507