(10 nodes) Mixed, incl. Peptidyl-diphthamide metabolic process, and GNAT domain network (Methanococcoides methylutens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKB84687.1	GCN5-related N-acetyltransferase. (125 aa)
	dphB	Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (267 aa)
	AKB85965.1	Iron-sulfur cluster-binding protein. (371 aa)
	AKB85966.1	Uncharacterized protein conserved in archaea (DUF531). (189 aa)
	AKB85967.1	N-acetylglutamate synthase. (148 aa)
	AKB85969.1	Hypothetical protein. (147 aa)
	AKB85970.1	ChlI component of cobalt chelatase involved in B12 biosynthesis. (374 aa)
	AKB85971.1	Hypothetical protein. (532 aa)
	AKB85973.1	Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. (331 aa)
	AKB85974.1	Ribosomal protein L11 methyltransferase. (201 aa)

Your Current Organism:

Methanococcoides methylutens

NCBI taxonomy Id: 1434104
Other names: M. methylutens MM1, Methanococcoides methylutens MM1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB84687.1	AKB85967.1	MCMEM_0634	MCMEM_1914	GCN5-related N-acetyltransferase.	N-acetylglutamate synthase.	0.916
AKB85965.1	AKB85966.1	MCMEM_1912	MCMEM_1913	Iron-sulfur cluster-binding protein.	Uncharacterized protein conserved in archaea (DUF531).	0.736
AKB85965.1	AKB85967.1	MCMEM_1912	MCMEM_1914	Iron-sulfur cluster-binding protein.	N-acetylglutamate synthase.	0.746
AKB85965.1	AKB85969.1	MCMEM_1912	MCMEM_1916	Iron-sulfur cluster-binding protein.	Hypothetical protein.	0.501
AKB85965.1	AKB85970.1	MCMEM_1912	MCMEM_1917	Iron-sulfur cluster-binding protein.	ChlI component of cobalt chelatase involved in B12 biosynthesis.	0.423
AKB85965.1	AKB85971.1	MCMEM_1912	MCMEM_1918	Iron-sulfur cluster-binding protein.	Hypothetical protein.	0.407
AKB85966.1	AKB85965.1	MCMEM_1913	MCMEM_1912	Uncharacterized protein conserved in archaea (DUF531).	Iron-sulfur cluster-binding protein.	0.736
AKB85966.1	AKB85967.1	MCMEM_1913	MCMEM_1914	Uncharacterized protein conserved in archaea (DUF531).	N-acetylglutamate synthase.	0.780
AKB85966.1	AKB85969.1	MCMEM_1913	MCMEM_1916	Uncharacterized protein conserved in archaea (DUF531).	Hypothetical protein.	0.542
AKB85966.1	AKB85970.1	MCMEM_1913	MCMEM_1917	Uncharacterized protein conserved in archaea (DUF531).	ChlI component of cobalt chelatase involved in B12 biosynthesis.	0.455
AKB85966.1	AKB85971.1	MCMEM_1913	MCMEM_1918	Uncharacterized protein conserved in archaea (DUF531).	Hypothetical protein.	0.437
AKB85966.1	AKB85973.1	MCMEM_1913	MCMEM_1920	Uncharacterized protein conserved in archaea (DUF531).	Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.	0.474
AKB85967.1	AKB84687.1	MCMEM_1914	MCMEM_0634	N-acetylglutamate synthase.	GCN5-related N-acetyltransferase.	0.916
AKB85967.1	AKB85965.1	MCMEM_1914	MCMEM_1912	N-acetylglutamate synthase.	Iron-sulfur cluster-binding protein.	0.746
AKB85967.1	AKB85966.1	MCMEM_1914	MCMEM_1913	N-acetylglutamate synthase.	Uncharacterized protein conserved in archaea (DUF531).	0.780
AKB85967.1	AKB85969.1	MCMEM_1914	MCMEM_1916	N-acetylglutamate synthase.	Hypothetical protein.	0.529
AKB85967.1	AKB85970.1	MCMEM_1914	MCMEM_1917	N-acetylglutamate synthase.	ChlI component of cobalt chelatase involved in B12 biosynthesis.	0.441
AKB85967.1	AKB85971.1	MCMEM_1914	MCMEM_1918	N-acetylglutamate synthase.	Hypothetical protein.	0.423
AKB85969.1	AKB85965.1	MCMEM_1916	MCMEM_1912	Hypothetical protein.	Iron-sulfur cluster-binding protein.	0.501
AKB85969.1	AKB85966.1	MCMEM_1916	MCMEM_1913	Hypothetical protein.	Uncharacterized protein conserved in archaea (DUF531).	0.542