(24 nodes) Ribosomal subunit network (Methanococcoides methylutens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	top6B	DNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (622 aa)
	rpl1	LSU ribosomal protein L10Ae (L1p); Binds directly to 23S rRNA. Probably involved in E site tRNA release. (213 aa)
	rpl18e	LSU ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family. (126 aa)
	rpl13	LSU ribosomal protein L13Ae (L13p); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (139 aa)
	rps9	SSU ribosomal protein S16e (S9p); Belongs to the universal ribosomal protein uS9 family. (134 aa)
	rps2	SSU ribosomal protein SAe (S2p); Belongs to the universal ribosomal protein uS2 family. (214 aa)
	rpl2	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (237 aa)
	rps19p	SSU ribosomal protein S15e (S19p); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (137 aa)
	rpl22	LSU ribosomal protein L17e (L22p); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (151 aa)
	rps3	SSU ribosomal protein S3e (S3p); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (304 aa)
	rpl24	LSU ribosomal protein L26e (L24p); Located at the polypeptide exit tunnel on the outside of the subunit. (117 aa)
	rps14	SSU ribosomal protein S29e (S14p); Binds 16S rRNA, required for the assembly of 30S particles. (50 aa)
	rpl32e	LSU ribosomal protein L32e; Belongs to the eukaryotic ribosomal protein eL32 family. (148 aa)
	rpl19e	LSU ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
	rps5	SSU ribosomal protein S2e (S5p); With S4 and S12 plays an important role in translational accuracy. (211 aa)
	rpl30	LSU ribosomal protein L7e (L30p). (153 aa)
	rpl15	LSU ribosomal protein L27Ae (L15p); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
	rps4	SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (184 aa)
	rpl31e	LSU ribosomal protein L31e; Belongs to the ribosomal protein L31e family. (88 aa)
	rps28e	SSU ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (71 aa)
	rps10	SSU ribosomal protein S20e (S10p); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
	rps7	SSU ribosomal protein S5e (S7p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (186 aa)
	rps12	SSU ribosomal protein S23e (S12p); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa)
	AKB85696.1	LSU ribosomal protein L30e. (95 aa)

Your Current Organism:

Methanococcoides methylutens

NCBI taxonomy Id: 1434104
Other names: M. methylutens MM1, Methanococcoides methylutens MM1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB85696.1	rpl1	MCMEM_1643	MCMEM_0169	LSU ribosomal protein L30e.	LSU ribosomal protein L10Ae (L1p); Binds directly to 23S rRNA. Probably involved in E site tRNA release.	0.999
AKB85696.1	rpl13	MCMEM_1643	MCMEM_0535	LSU ribosomal protein L30e.	LSU ribosomal protein L13Ae (L13p); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.999
AKB85696.1	rpl15	MCMEM_1643	MCMEM_0606	LSU ribosomal protein L30e.	LSU ribosomal protein L27Ae (L15p); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.999
AKB85696.1	rpl18e	MCMEM_1643	MCMEM_0534	LSU ribosomal protein L30e.	LSU ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family.	0.999
AKB85696.1	rpl19e	MCMEM_1643	MCMEM_0602	LSU ribosomal protein L30e.	LSU ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.	0.999
AKB85696.1	rpl2	MCMEM_1643	MCMEM_0588	LSU ribosomal protein L30e.	LSU ribosomal protein L8e (L2p); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.999
AKB85696.1	rpl22	MCMEM_1643	MCMEM_0590	LSU ribosomal protein L30e.	LSU ribosomal protein L17e (L22p); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.999
AKB85696.1	rpl24	MCMEM_1643	MCMEM_0595	LSU ribosomal protein L30e.	LSU ribosomal protein L26e (L24p); Located at the polypeptide exit tunnel on the outside of the subunit.	0.999
AKB85696.1	rpl30	MCMEM_1643	MCMEM_0605	LSU ribosomal protein L30e.	LSU ribosomal protein L7e (L30p).	0.999
AKB85696.1	rpl31e	MCMEM_1643	MCMEM_0697	LSU ribosomal protein L30e.	LSU ribosomal protein L31e; Belongs to the ribosomal protein L31e family.	0.999
AKB85696.1	rpl32e	MCMEM_1643	MCMEM_0601	LSU ribosomal protein L30e.	LSU ribosomal protein L32e; Belongs to the eukaryotic ribosomal protein eL32 family.	0.999
AKB85696.1	rps10	MCMEM_1643	MCMEM_1637	LSU ribosomal protein L30e.	SSU ribosomal protein S20e (S10p); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.999
AKB85696.1	rps12	MCMEM_1643	MCMEM_1641	LSU ribosomal protein L30e.	SSU ribosomal protein S23e (S12p); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.	0.999
AKB85696.1	rps14	MCMEM_1643	MCMEM_0598	LSU ribosomal protein L30e.	SSU ribosomal protein S29e (S14p); Binds 16S rRNA, required for the assembly of 30S particles.	0.999
AKB85696.1	rps19p	MCMEM_1643	MCMEM_0589	LSU ribosomal protein L30e.	SSU ribosomal protein S15e (S19p); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.	0.999
AKB85696.1	rps2	MCMEM_1643	MCMEM_0539	LSU ribosomal protein L30e.	SSU ribosomal protein SAe (S2p); Belongs to the universal ribosomal protein uS2 family.	0.999
AKB85696.1	rps28e	MCMEM_1643	MCMEM_0784	LSU ribosomal protein L30e.	SSU ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.	0.999
AKB85696.1	rps3	MCMEM_1643	MCMEM_0591	LSU ribosomal protein L30e.	SSU ribosomal protein S3e (S3p); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.	0.999
AKB85696.1	rps4	MCMEM_1643	MCMEM_0620	LSU ribosomal protein L30e.	SSU ribosomal protein S9e (S4p); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.	0.998
AKB85696.1	rps5	MCMEM_1643	MCMEM_0604	LSU ribosomal protein L30e.	SSU ribosomal protein S2e (S5p); With S4 and S12 plays an important role in translational accuracy.	0.999