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trpF trpF AKB80728.1 AKB80728.1 trpC trpC trpB trpB trpA trpA trpD trpD trpF-2 trpF-2 trpE trpE AKB81080.1 AKB81080.1 AKB81652.1 AKB81652.1 trpB-2 trpB-2 hisD hisD hisI hisI hisH hisH hisF hisF hisB hisB hisA hisA hisG hisG hisC hisC AKB83881.1 AKB83881.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpFPhosphoribosylanthranilate isomerase; Belongs to the TrpF family. (226 aa)
AKB80728.1Hypothetical protein. (215 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (426 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa)
trpF-2Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (238 aa)
trpEAnthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (547 aa)
AKB81080.1Anthranilate synthase, amidotransferase component. (200 aa)
AKB81652.1Phosphoribosyl-ATP pyrophosphatase. (66 aa)
trpB-2Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (432 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa)
hisHImidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa)
hisBImidazoleglycerol-phosphate dehydratase. (186 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa)
hisCAspartate aminotransferase / Histidinol-phosphate aminotransferase. (359 aa)
AKB83881.1Phosphoserine phosphatase. (230 aa)
Your Current Organism:
Methanosarcina barkeri 3
NCBI taxonomy Id: 1434107
Other names: M. barkeri 3
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