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AKB80620.1 AKB80620.1 AKB80766.1 AKB80766.1 AKB80863.1 AKB80863.1 ppcA ppcA ilvD ilvD leuD leuD AKB81625.1 AKB81625.1 leuC leuC AKB81704.1 AKB81704.1 AKB81710.1 AKB81710.1 AKB81711.1 AKB81711.1 leuC-2 leuC-2 AKB82453.1 AKB82453.1 AKB82454.1 AKB82454.1 AKB82610.1 AKB82610.1 AKB82624.1 AKB82624.1 AKB82704.1 AKB82704.1 AKB82705.1 AKB82705.1 leuD-2 leuD-2 AKB82800.1 AKB82800.1 ilvD-2 ilvD-2 AKB83260.1 AKB83260.1 cimA cimA AKB83306.1 AKB83306.1 AKB83307.1 AKB83307.1 AKB83308.1 AKB83308.1 AKB83309.1 AKB83309.1 ilvC ilvC hacB hacB AKB83342.1 AKB83342.1 ilvE ilvE AKB83718.1 AKB83718.1 AKB83719.1 AKB83719.1 AKB84030.1 AKB84030.1 AKB84031.1 AKB84031.1 AKB84032.1 AKB84032.1 AKB84033.1 AKB84033.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKB80620.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (502 aa)
AKB80766.1Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)
AKB80863.1Acetolactate synthase; Belongs to the TPP enzyme family. (544 aa)
ppcAPhosphoenolpyruvate carboxylase, archaeal; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (526 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
leuDCoenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa)
AKB81625.1Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa)
AKB81704.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (815 aa)
AKB81710.12-oxoglutarate oxidoreductase, beta subunit. (283 aa)
AKB81711.12-oxoglutarate oxidoreductase, alpha subunit. (579 aa)
leuC-2Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
AKB82453.1Pyruvate carboxyl transferase subunit B. (620 aa)
AKB82454.1Pyruvate carboxyl transferase subunit A. (493 aa)
AKB82610.1Pyruvate,phosphate dikinase. (881 aa)
AKB82624.1Indole-3-pyruvate decarboxylase. (542 aa)
AKB82704.1Citrate synthase (si). (355 aa)
AKB82705.1Aconitate hydratase. (934 aa)
leuD-23-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa)
AKB82800.13-isopropylmalate dehydrogenase. (375 aa)
ilvD-2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
AKB83260.1Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
cimA(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (483 aa)
AKB83306.1Acetolactate synthase large subunit. (588 aa)
AKB83307.1Acetolactate synthase small subunit. (161 aa)
AKB83308.1Acetolactate synthase large subunit. (563 aa)
AKB83309.1Acetolactate synthase small subunit. (162 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
hacBCoenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa)
AKB83342.1Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
AKB83718.13-isopropylmalate dehydrogenase. (342 aa)
AKB83719.12-isopropylmalate synthase. (442 aa)
AKB84030.1Pyruvate:ferredoxin oxidoreductase, gamma subunit. (182 aa)
AKB84031.1Pyruvate:ferredoxin oxidoreductase, delta subunit. (110 aa)
AKB84032.1Pyruvate:ferredoxin oxidoreductase, alpha subunit. (402 aa)
AKB84033.1Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)
Your Current Organism:
Methanosarcina barkeri 3
NCBI taxonomy Id: 1434107
Other names: M. barkeri 3
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