node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB80620.1 | AKB81625.1 | MSBR3_0042 | MSBR3_1047 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.907 |
AKB80620.1 | AKB82705.1 | MSBR3_0042 | MSBR3_2127 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Aconitate hydratase. | 0.656 |
AKB80620.1 | AKB83342.1 | MSBR3_0042 | MSBR3_2764 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. | 0.775 |
AKB80620.1 | AKB83718.1 | MSBR3_0042 | MSBR3_3140 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase. | 0.760 |
AKB80620.1 | hacB | MSBR3_0042 | MSBR3_2760 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] | 0.861 |
AKB80620.1 | leuC | MSBR3_0042 | MSBR3_1073 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.988 |
AKB80620.1 | leuC-2 | MSBR3_0042 | MSBR3_1673 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.884 |
AKB80620.1 | leuD | MSBR3_0042 | MSBR3_1018 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.843 |
AKB80620.1 | leuD-2 | MSBR3_0042 | MSBR3_2221 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.987 |
AKB81625.1 | AKB80620.1 | MSBR3_1047 | MSBR3_0042 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.907 |
AKB81625.1 | AKB82705.1 | MSBR3_1047 | MSBR3_2127 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Aconitate hydratase. | 0.656 |
AKB81625.1 | AKB83342.1 | MSBR3_1047 | MSBR3_2764 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. | 0.979 |
AKB81625.1 | AKB83718.1 | MSBR3_1047 | MSBR3_3140 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase. | 0.779 |
AKB81625.1 | hacB | MSBR3_1047 | MSBR3_2760 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] | 0.984 |
AKB81625.1 | leuC | MSBR3_1047 | MSBR3_1073 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.881 |
AKB81625.1 | leuC-2 | MSBR3_1047 | MSBR3_1673 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.986 |
AKB81625.1 | leuD | MSBR3_1047 | MSBR3_1018 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.984 |
AKB81625.1 | leuD-2 | MSBR3_1047 | MSBR3_2221 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.857 |
AKB82704.1 | AKB82705.1 | MSBR3_2126 | MSBR3_2127 | Citrate synthase (si). | Aconitate hydratase. | 0.999 |
AKB82704.1 | AKB83342.1 | MSBR3_2126 | MSBR3_2764 | Citrate synthase (si). | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. | 0.847 |