(17 nodes) Iron-sulfur cluster assembly, and Thil, AANH domain network (Methanosarcina barkeri 3)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	iscS	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (396 aa)
	AKB80643.1	Scaffold protein. (129 aa)
	AKB81410.1	Scaffold protein. (129 aa)
	iscS-2	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (394 aa)
	thiI	tRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (405 aa)
	iscS-3	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (394 aa)
	AKB81545.1	Scaffold protein. (129 aa)
	AKB81572.1	Molybdenum cofactor sulfurase. (514 aa)
	thiI-2	tRNA S(4)U 4-thiouridine synthase (former ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (436 aa)
	AKB82097.1	Putative iron binding protein from the HesB_IscA_SufA family. (106 aa)
	AKB82129.1	Iron-sulfur cluster assembly protein SufB. (320 aa)
	AKB82130.1	Iron-sulfur cluster assembly ATPase protein SufC. (235 aa)
	AKB82301.1	Homocysteine desulfhydrase. (398 aa)
	AKB82302.1	Scaffold protein. (211 aa)
	AKB82691.1	Cysteine desulfurase. (393 aa)
	AKB83863.1	Iron-sulfur cluster assembly ATPase protein SufC. (247 aa)
	AKB83864.1	Iron-sulfur cluster assembly protein SufB. (407 aa)

Your Current Organism:

Methanosarcina barkeri 3

NCBI taxonomy Id: 1434107
Other names: M. barkeri 3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB80643.1	AKB81572.1	MSBR3_0065	MSBR3_0994	Scaffold protein.	Molybdenum cofactor sulfurase.	0.932
AKB80643.1	AKB82097.1	MSBR3_0065	MSBR3_1519	Scaffold protein.	Putative iron binding protein from the HesB_IscA_SufA family.	0.740
AKB80643.1	AKB82129.1	MSBR3_0065	MSBR3_1551	Scaffold protein.	Iron-sulfur cluster assembly protein SufB.	0.703
AKB80643.1	AKB82130.1	MSBR3_0065	MSBR3_1552	Scaffold protein.	Iron-sulfur cluster assembly ATPase protein SufC.	0.706
AKB80643.1	AKB82301.1	MSBR3_0065	MSBR3_1723	Scaffold protein.	Homocysteine desulfhydrase.	0.918
AKB80643.1	AKB82691.1	MSBR3_0065	MSBR3_2113	Scaffold protein.	Cysteine desulfurase.	0.932
AKB80643.1	AKB83863.1	MSBR3_0065	MSBR3_3285	Scaffold protein.	Iron-sulfur cluster assembly ATPase protein SufC.	0.706
AKB80643.1	AKB83864.1	MSBR3_0065	MSBR3_3286	Scaffold protein.	Iron-sulfur cluster assembly protein SufB.	0.712
AKB80643.1	iscS	MSBR3_0065	MSBR3_0064	Scaffold protein.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.954
AKB80643.1	iscS-2	MSBR3_0065	MSBR3_0833	Scaffold protein.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.907
AKB80643.1	iscS-3	MSBR3_0065	MSBR3_0966	Scaffold protein.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.907
AKB81410.1	AKB81572.1	MSBR3_0832	MSBR3_0994	Scaffold protein.	Molybdenum cofactor sulfurase.	0.932
AKB81410.1	AKB82097.1	MSBR3_0832	MSBR3_1519	Scaffold protein.	Putative iron binding protein from the HesB_IscA_SufA family.	0.740
AKB81410.1	AKB82129.1	MSBR3_0832	MSBR3_1551	Scaffold protein.	Iron-sulfur cluster assembly protein SufB.	0.703
AKB81410.1	AKB82130.1	MSBR3_0832	MSBR3_1552	Scaffold protein.	Iron-sulfur cluster assembly ATPase protein SufC.	0.706
AKB81410.1	AKB82301.1	MSBR3_0832	MSBR3_1723	Scaffold protein.	Homocysteine desulfhydrase.	0.918
AKB81410.1	AKB82691.1	MSBR3_0832	MSBR3_2113	Scaffold protein.	Cysteine desulfurase.	0.932
AKB81410.1	AKB83863.1	MSBR3_0832	MSBR3_3285	Scaffold protein.	Iron-sulfur cluster assembly ATPase protein SufC.	0.706
AKB81410.1	AKB83864.1	MSBR3_0832	MSBR3_3286	Scaffold protein.	Iron-sulfur cluster assembly protein SufB.	0.712
AKB81410.1	iscS	MSBR3_0832	MSBR3_0064	Scaffold protein.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.	0.909