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| | AKB82202.1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase. (418 aa) |
| | AKB80620.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (502 aa) |
| | AKB80644.1 | Tetrahydromethanopterin:alpha-L-glutamate ligase. (338 aa) |
| | AKB80658.1 | Ferredoxin oxidoreductase. (438 aa) |
| | AKB80660.1 | Cysteate synthase; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (416 aa) |
| | AKB80685.1 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (226 aa) |
| | AKB80762.1 | Shikimate kinase I. (45 aa) |
| | AKB80763.1 | Shikimate kinase I. (76 aa) |
| | AKB80827.1 | 7,8 dihydropteroate synthase (methanopterin). (325 aa) |
| | AKB80857.1 | Hydrolase, HAD superfamily. (240 aa) |
| | AKB80985.1 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa) |
| | AKB81056.1 | Dimethylamine methyltransferase corrinoid protein. (214 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (426 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (238 aa) |
| | trpE | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (547 aa) |
| | AKB81173.1 | Chorismate mutase I. (95 aa) |
| | aroK | Shikimate kinase II. (287 aa) |
| | AKB81197.1 | Dimethylamine methyltransferase corrinoid protein. (214 aa) |
| | AKB81219.1 | Aminoacyl-histidine dipeptidase (Peptidase D). (506 aa) |
| | AKB81363.1 | Shikimate kinase I. (169 aa) |
| | AKB81423.1 | Ferredoxin oxidoreductase. (414 aa) |
| | AKB81433.1 | O-succinylhomoserine sulfhydrylase. (430 aa) |
| | AKB81523.1 | LL-diaminopimelate aminotransferase, methanococcal. (385 aa) |
| | AKB81541.1 | Serine acetyltransferase; PaaD-like protein (DUF59) involved in Fe-S cluster assembly. (314 aa) |
| | AKB81542.1 | Cysteine synthase. (308 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | AKB81547.1 | O-succinylhomoserine sulfhydrylase. (452 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (543 aa) |
| | AKB81569.1 | Aminoacyl-histidine dipeptidase (Peptidase D). (535 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | leuD | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa) |
| | AKB81625.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa) |
| | gap | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase archaeal. (338 aa) |
| | AKB81638.1 | Glutamine synthetase type I. (506 aa) |
| | AKB81641.1 | Ornithine decarboxylase. (390 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa) |
| | AKB81652.1 | Phosphoribosyl-ATP pyrophosphatase. (66 aa) |
| | AKB81677.1 | Argininosuccinate synthase. (96 aa) |
| | AKB81687.1 | Argininosuccinate synthase. (82 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1070 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (369 aa) |
| | AKB81695.1 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa) |
| | AKB81707.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (325 aa) |
| | AKB81720.1 | Hypothetical protein. (239 aa) |
| | gap-2 | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase archaeal. (338 aa) |
| | AKB81733.1 | Putative methyltransferase. (291 aa) |
| | AKB81747.1 | Asparagine synthetase (glutamine-hydrolyzing). (633 aa) |
| | AKB81767.1 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (258 aa) |
| | AKB81881.1 | Hypothetical protein. (229 aa) |
| | AKB81929.1 | Homoserine dehydrogenase. (331 aa) |
| | argH | Argininosuccinate lyase. (491 aa) |
| | AKB81987.1 | Hypothetical protein. (280 aa) |
| | trpB-2 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (432 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | AKB82046.1 | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. (411 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | glyA | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (122 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | AKB82118.1 | Galactoside O-acetyltransferase. (198 aa) |
| | hisS | Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (409 aa) |
| | nadA-2 | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | AKB82188.1 | Chloramphenicol acetyltransferase. (176 aa) |
| | AKB82193.1 | Acetyltransferase (isoleucine patch superfamily). (219 aa) |
| | AKB82200.1 | Serine acetyltransferase. (120 aa) |
| | AKB82219.1 | Hypothetical protein. (284 aa) |
| | AKB82227.1 | Prephenate dehydratase. (297 aa) |
| | leuC-2 | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa) |
| | AKB82264.1 | Haloacid dehalogenase-like hydrolase. (258 aa) |
| | AKB82269.1 | Uroporphyrinogen-III synthase. (263 aa) |
| | AKB82457.1 | Phosphoserine phosphatase. (319 aa) |
| | AKB82475.1 | Indolepyruvate oxidoreductase subunit IorA. (239 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | AKB82528.1 | Dimethylamine methyltransferase corrinoid protein. (208 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (273 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | AKB82626.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | AKB82658.1 | Aspartate-semialdehyde dehydrogenase. (342 aa) |
| | aroA | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (186 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | AKB82800.1 | 3-isopropylmalate dehydrogenase. (375 aa) |
| | AKB82852.1 | Proline reductase for pyrrolysine biosynthesis. (259 aa) |
| | AKB82853.1 | Pyrrolysine synthetase. (363 aa) |
| | AKB82854.1 | Proline 2-methylase for pyrrolysine biosynthesis. (350 aa) |
| | AKB82876.1 | Aspartokinase; Belongs to the aspartokinase family. (472 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa) |
| | hisC | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. (359 aa) |
| | aroA-2 | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | aroA-3 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (240 aa) |
| | aroB | 3,7-dideoxy-D-threo-hepto-2, 6-diulosonate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (380 aa) |
| | aroD | 3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (247 aa) |
| | aroE | Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | AKB82946.1 | Prephenate and/or arogenate dehydrogenase (unknown specificity). (528 aa) |
| | serS | Seryl-tRNA synthetase, archaeal; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily. (502 aa) |
| | AKB82977.1 | 7,8 dihydropteroate synthase (methanopterin). (53 aa) |
| | AKB83022.1 | Hypothetical protein. (128 aa) |
| | AKB83023.1 | Inosine-5'-monophosphate dehydrogenase. (500 aa) |
| | AKB83028.1 | Serine--glyoxylate aminotransferase. (78 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AKB83054.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa) |
| | AKB83212.1 | Hypothetical protein. (170 aa) |
| | AKB83261.1 | Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase. (307 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (483 aa) |
| | AKB83307.1 | Acetolactate synthase small subunit. (161 aa) |
| | AKB83309.1 | Acetolactate synthase small subunit. (162 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa) |
| | hacB | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa) |
| | AKB83342.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (330 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (407 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (383 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (447 aa) |
| | AKB83626.1 | Metal-dependent hydrolases of the beta-lactamase superfamily I; PhnP protein. (242 aa) |
| | serS-2 | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (399 aa) |
| | AKB83653.1 | Hypothetical protein. (230 aa) |
| | AKB83655.1 | Serine O-acetyltransferase. (211 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | AKB83718.1 | 3-isopropylmalate dehydrogenase. (342 aa) |
| | AKB83756.1 | Glutamate synthase [NADPH] large chain; Belongs to the glutamate synthase family. (503 aa) |
| | AKB83758.1 | Glutamine synthetase type I. (440 aa) |
| | AKB83809.1 | Haloacid dehalogenase-like hydrolase. (217 aa) |
| | AKB83862.1 | 7,8 dihydropteroate synthase (methanopterin). (220 aa) |
| | AKB83880.1 | Phosphoserine phosphatase. (285 aa) |
| | AKB83881.1 | Phosphoserine phosphatase. (230 aa) |
| | AKB83887.1 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (237 aa) |
| | AKB83903.1 | UDP-glucose dehydrogenase. (427 aa) |
| | AKB83919.1 | Acetyltransferase. (222 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa) |
| | AKB83999.1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (362 aa) |
