node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKB80624.1 | AKB80625.1 | MSBR3_0046 | MSBR3_0047 | Phosphopantothenoylcysteine synthetase. | Pantoate kinase, archaeal. | 0.931 |
AKB80624.1 | AKB80626.1 | MSBR3_0046 | MSBR3_0048 | Phosphopantothenoylcysteine synthetase. | Phosphopantothenate synthetase, archaeal. | 0.975 |
AKB80624.1 | coaD | MSBR3_0046 | MSBR3_1492 | Phosphopantothenoylcysteine synthetase. | Phosphopantetheine adenylyltransferase, type II eukaryotic; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. | 0.971 |
AKB80625.1 | AKB80624.1 | MSBR3_0047 | MSBR3_0046 | Pantoate kinase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.931 |
AKB80625.1 | AKB80626.1 | MSBR3_0047 | MSBR3_0048 | Pantoate kinase, archaeal. | Phosphopantothenate synthetase, archaeal. | 0.997 |
AKB80625.1 | AKB83375.1 | MSBR3_0047 | MSBR3_2797 | Pantoate kinase, archaeal. | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.630 |
AKB80625.1 | ilvC | MSBR3_0047 | MSBR3_2732 | Pantoate kinase, archaeal. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.777 |
AKB80626.1 | AKB80624.1 | MSBR3_0048 | MSBR3_0046 | Phosphopantothenate synthetase, archaeal. | Phosphopantothenoylcysteine synthetase. | 0.975 |
AKB80626.1 | AKB80625.1 | MSBR3_0048 | MSBR3_0047 | Phosphopantothenate synthetase, archaeal. | Pantoate kinase, archaeal. | 0.997 |
AKB80626.1 | AKB83375.1 | MSBR3_0048 | MSBR3_2797 | Phosphopantothenate synthetase, archaeal. | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.492 |
AKB80626.1 | mfnA | MSBR3_0048 | MSBR3_3475 | Phosphopantothenate synthetase, archaeal. | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.926 |
AKB80863.1 | AKB83306.1 | MSBR3_0285 | MSBR3_2728 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.913 |
AKB80863.1 | AKB83307.1 | MSBR3_0285 | MSBR3_2729 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.994 |
AKB80863.1 | AKB83308.1 | MSBR3_0285 | MSBR3_2730 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.915 |
AKB80863.1 | AKB83309.1 | MSBR3_0285 | MSBR3_2731 | Acetolactate synthase; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.994 |
AKB80863.1 | ilvC | MSBR3_0285 | MSBR3_2732 | Acetolactate synthase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.989 |
AKB80863.1 | ilvD | MSBR3_0285 | MSBR3_1005 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.629 |
AKB80863.1 | ilvD-2 | MSBR3_0285 | MSBR3_2460 | Acetolactate synthase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.630 |
AKB80863.1 | ilvE | MSBR3_0285 | MSBR3_3099 | Acetolactate synthase; Belongs to the TPP enzyme family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.852 |
AKB80863.1 | mfnA | MSBR3_0285 | MSBR3_3475 | Acetolactate synthase; Belongs to the TPP enzyme family. | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.436 |