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nth nth fen fen nth-2 nth-2 AKB77440.1 AKB77440.1 AKB77462.1 AKB77462.1 AKB77464.1 AKB77464.1 AKB77789.1 AKB77789.1 AKB77920.1 AKB77920.1 AKB78816.1 AKB78816.1 AKB79047.1 AKB79047.1 lig lig AKB79571.1 AKB79571.1 AKB79765.1 AKB79765.1 AKB79875.1 AKB79875.1 lig-2 lig-2 pcn pcn
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (205 aa)
fenFlap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (338 aa)
nth-2Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (234 aa)
AKB77440.1Uracil-DNA glycosylase, family 4. (197 aa)
AKB77462.18-oxoguanine DNA glycosylase. (282 aa)
AKB77464.18-oxoguanine DNA glycosylase. (150 aa)
AKB77789.1Single-stranded-DNA-specific exonuclease RecJ. (445 aa)
AKB77920.1Exodeoxyribonuclease III. (258 aa)
AKB78816.1Hypothetical protein. (203 aa)
AKB79047.1Phosphoesterase. (336 aa)
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (568 aa)
AKB79571.1Endonuclease IV. (277 aa)
AKB79765.1Hypothetical protein. (160 aa)
AKB79875.1Single-stranded-DNA-specific exonuclease RecJ. (466 aa)
lig-2ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (580 aa)
pcnDNA polymerase sliding clamp protein PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (245 aa)
Your Current Organism:
Methanosarcina horonobensis
NCBI taxonomy Id: 1434110
Other names: M. horonobensis HB-1 = JCM 15518, Methanosarcina horonobensis HB-1, Methanosarcina horonobensis HB-1 = JCM 15518, Methanosarcina horonobensis JCM 15518, Methanosarcina horonobensis JCM 15518 = HB-1, Methanosarcina sp. HB-1
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