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AKB73285.1 AKB73285.1 mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA mtrA mtrF mtrF mtrG mtrG mtrH mtrH AKB73350.1 AKB73350.1 AKB73351.1 AKB73351.1 AKB73417.1 AKB73417.1 AKB73418.1 AKB73418.1 AKB73419.1 AKB73419.1 AKB73420.1 AKB73420.1 AKB73421.1 AKB73421.1 AKB73499.1 AKB73499.1 AKB73507.1 AKB73507.1 AKB73525.1 AKB73525.1 AKB73526.1 AKB73526.1 AKB73527.1 AKB73527.1 AKB73546.1 AKB73546.1 AKB73547.1 AKB73547.1 AKB73548.1 AKB73548.1 AKB73553.1 AKB73553.1 AKB73683.1 AKB73683.1 AKB73684.1 AKB73684.1 AKB73685.1 AKB73685.1 AKB73686.1 AKB73686.1 AKB73697.1 AKB73697.1 AKB73703.1 AKB73703.1 rnfC rnfC cdhE cdhE cdhD cdhD cdhC cdhC cdhB cdhB cdhA cdhA AKB73948.1 AKB73948.1 AKB73950.1 AKB73950.1 AKB73951.1 AKB73951.1 AKB73952.1 AKB73952.1 AKB74113.1 AKB74113.1 AKB74151.1 AKB74151.1 AKB74265.1 AKB74265.1 AKB74266.1 AKB74266.1 AKB74267.1 AKB74267.1 AKB74273.1 AKB74273.1 AKB74277.1 AKB74277.1 AKB74289.1 AKB74289.1 mch mch AKB74640.1 AKB74640.1 AKB74642.1 AKB74642.1 fpoH fpoH AKB74715.1 AKB74715.1 AKB74718.1 AKB74718.1 AKB74719.1 AKB74719.1 AKB74720.1 AKB74720.1 AKB74721.1 AKB74721.1 AKB74839.1 AKB74839.1 AKB74842.1 AKB74842.1 AKB74843.1 AKB74843.1 AKB74928.1 AKB74928.1 AKB74929.1 AKB74929.1 AKB75441.1 AKB75441.1 AKB75463.1 AKB75463.1 AKB75464.1 AKB75464.1 AKB75465.1 AKB75465.1 mer mer cbiX cbiX AKB75564.1 AKB75564.1 AKB75565.1 AKB75565.1 AKB75566.1 AKB75566.1 cbiA cbiA AKB75647.1 AKB75647.1 AKB75673.1 AKB75673.1 AKB75674.1 AKB75674.1 AKB75738.1 AKB75738.1 AKB75739.1 AKB75739.1 AKB75740.1 AKB75740.1 AKB75884.1 AKB75884.1 AKB75885.1 AKB75885.1 AKB75887.1 AKB75887.1 AKB75899.1 AKB75899.1 AKB76045.1 AKB76045.1 AKB76046.1 AKB76046.1 mtd mtd AKB76199.1 AKB76199.1 AKB76217.1 AKB76217.1 AKB76226.1 AKB76226.1 AKB76234.1 AKB76234.1 AKB76235.1 AKB76235.1 AKB76237.1 AKB76237.1 ftr ftr AKB76463.1 AKB76463.1 AKB76465.1 AKB76465.1 AKB76467.1 AKB76467.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKB73285.1Fe-S oxidoreductase; Homology to heterodisulfide reductase 2 iron-sulfur subunit. (392 aa)
mtrEN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (304 aa)
mtrDN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (249 aa)
mtrCN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (266 aa)
mtrBN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (108 aa)
mtrAN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (240 aa)
mtrFN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit F; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (72 aa)
mtrGN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (73 aa)
mtrHN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA. (316 aa)
AKB73350.1Aconitate hydratase. (935 aa)
AKB73351.1Citrate synthase (si). (355 aa)
AKB73417.1Methyl coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (571 aa)
AKB73418.1Methyl coenzyme M reductase gamma subunit. (248 aa)
AKB73419.1Methyl coenzyme M reductase operon protein C. (206 aa)
AKB73420.1Methyl coenzyme M reductase operon protein D. (170 aa)
AKB73421.1Methyl coenzyme M reductase beta subunit. (434 aa)
AKB73499.1Methanol methyltransferase corrinoid protein. (258 aa)
AKB73507.1Na(+) H(+) antiporter subunit D. (522 aa)
AKB73525.1Formylmethanofuran dehydrogenase (molybdenum) subunit C. (269 aa)
AKB73526.1Formylmethanofuran dehydrogenase (molybdenum) subunit D. (129 aa)
AKB73527.1Formylmethanofuran dehydrogenase (molybdenum) subunit B. (433 aa)
AKB73546.1Fe-S oxidoreductase; Homology to heterodisulfide reductase 2 iron-sulfur subunit. (382 aa)
AKB73547.1Dimethylamine methyltransferase corrinoid protein. (164 aa)
AKB73548.1Trimethylamine:corrinoid methyltransferase; Pyrrolysine-containing; Belongs to the trimethylamine methyltransferase family. (495 aa)
AKB73553.1Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (467 aa)
AKB73683.1Polyprenyl synthetase. (206 aa)
AKB73684.1Polyprenyl synthetase. (70 aa)
AKB73685.1CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D. (419 aa)
AKB73686.1CoB--CoM heterodisulfide reductase 2 subunit E. (242 aa)
AKB73697.1Hypothetical protein. (210 aa)
AKB73703.1Ferredoxin. (87 aa)
rnfCElectron transport complex protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (437 aa)
cdhE5-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. (469 aa)
cdhDCO dehydrogenase/acetyl-CoA synthase subunit delta, corrinoid iron-sulfur subcomplex small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex. (437 aa)
cdhCCO dehydrogenase/acetyl-CoA synthase subunit beta, acetyl-CoA synthase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex). (469 aa)
cdhBCO dehydrogenase/acetyl-CoA synthase subunit epsilon, CO dehydrogenase subcomplex; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. (170 aa)
cdhACO dehydrogenase/acetyl-CoA synthase subunit alpha, CO dehydrogenase subcomplex; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (806 aa)
AKB73948.1Methanophenazine hydrogenase cytochrome b subunit. (135 aa)
AKB73950.1Methanophenazine hydrogenase small subunit precursor. (418 aa)
AKB73951.1Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (595 aa)
AKB73952.1Methanophenazine hydrogenase cytochrome b subunit. (260 aa)
AKB74113.1Methylthiol:coenzyme M methyltransferase corrinoid protein. (275 aa)
AKB74151.1Cacineurin superfamily phosphoesterase. (218 aa)
AKB74265.1Methanophenazine hydrogenase cytochrome b subunit. (267 aa)
AKB74266.1Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (596 aa)
AKB74267.1Methanophenazine hydrogenase small subunit precursor. (383 aa)
AKB74273.1Energy-conserving hydrogenase (ferredoxin), subunit A. (633 aa)
AKB74277.1Energy-conserving hydrogenase (ferredoxin), subunit F. (50 aa)
AKB74289.1N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A. (182 aa)
mchN(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (321 aa)
AKB74640.1Methylcobalamin:coenzyme M methyltransferase, methanol-specific. (339 aa)
AKB74642.1Methanol methyltransferase corrinoid protein. (255 aa)
fpoHFPO subunit H; FPO shuttles electrons from F(420)H(2), via FAD and iron- sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (345 aa)
AKB74715.1Hypothetical protein. (136 aa)
AKB74718.1NADH:ubiquinone oxidoreductase subunit K. (102 aa)
AKB74719.1NADH:ubiquinone oxidoreductase subunit L. (672 aa)
AKB74720.1NADH:ubiquinone oxidoreductase subunit M. (495 aa)
AKB74721.1NADH:ubiquinone oxidoreductase subunit N. (491 aa)
AKB74839.1CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (793 aa)
AKB74842.1Formylmethanofuran dehydrogenase subunit B. (414 aa)
AKB74843.1Formylmethanofuran dehydrogenase subunit D. (132 aa)
AKB74928.1Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (467 aa)
AKB74929.1Dimethylamine methyltransferase corrinoid protein. (214 aa)
AKB75441.1Iron-sulfur cluster binding protein. (177 aa)
AKB75463.1CoB--CoM heterodisulfide reductase subunit B. (296 aa)
AKB75464.1CoB--CoM heterodisulfide reductase subunit C. (236 aa)
AKB75465.1CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (813 aa)
mer5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (328 aa)
cbiXSirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (130 aa)
AKB75564.1UDP-N-acetylmuramoylalanine--D-glutamate ligase. (486 aa)
AKB75565.1Nitrogenase-related protein. (378 aa)
AKB75566.1Nitrogenase reductase-like protein. (265 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (502 aa)
AKB75647.1Nitrogenase (molybdenum-iron) reductase and maturation protein NifH; Nitrogenase FeMo-cofactor scaffold and assembly protein NifE; Belongs to the NifH/BchL/ChlL family. (804 aa)
AKB75673.1Acetyl-CoA synthetase (ADP-forming) alpha chain. (64 aa)
AKB75674.1Acetyl-CoA synthetase (ADP-forming) alpha chain. (56 aa)
AKB75738.1Trimethylamine:corrinoid methyltransferase; Pyrrolysine-containing; Belongs to the trimethylamine methyltransferase family. (495 aa)
AKB75739.1Dimethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (468 aa)
AKB75740.1Dimethylamine methyltransferase corrinoid protein. (216 aa)
AKB75884.1Formylmethanofuran dehydrogenase (tungsten) subunit D. (127 aa)
AKB75885.1Formylmethanofuran dehydrogenase subunit B. (434 aa)
AKB75887.1Formylmethanofuran dehydrogenase subunit C. (252 aa)
AKB75899.1Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (307 aa)
AKB76045.1CoB--CoM heterodisulfide reductase subunit C. (161 aa)
AKB76046.1CoB--CoM heterodisulfide reductase subunit B. (300 aa)
mtdF420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (276 aa)
AKB76199.1CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D. (1016 aa)
AKB76217.1Methanol methyltransferase corrinoid protein. (258 aa)
AKB76226.1Methylcobalamin:coenzyme M methyltransferase, methanol-specific. (342 aa)
AKB76234.1Hydrogenase-4 component F. (492 aa)
AKB76235.1Hydrogenase-4 component E. (232 aa)
AKB76237.1Hydrogenase, HycC subunit, putative. (645 aa)
ftrFormylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (297 aa)
AKB76463.1Monomethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (458 aa)
AKB76465.1Monomethylamine:corrinoid methyltransferase; Pyrrolysine-containing. (458 aa)
AKB76467.1Methylcobalamin:coenzyme M methyltransferase, methylamine-specific. (318 aa)
Your Current Organism:
Methanosarcina lacustris
NCBI taxonomy Id: 1434111
Other names: M. lacustris Z-7289, Methanosarcina lacustris Z-7289
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