(15 nodes) Citrate cycle (TCA cycle) network (Methanosarcina lacustris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AKB73350.1	Aconitate hydratase. (935 aa)
	AKB73351.1	Citrate synthase (si). (355 aa)
	AKB73699.1	Pyruvate carboxyl transferase subunit A. (493 aa)
	AKB73700.1	Pyruvate carboxyl transferase subunit B. (572 aa)
	AKB75371.1	2-oxoglutarate oxidoreductase, beta subunit. (283 aa)
	AKB75372.1	2-oxoglutarate oxidoreductase, alpha subunit. (579 aa)
	AKB75451.1	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase beta subunit. (196 aa)
	AKB75452.1	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase alpha subunit. (280 aa)
	AKB75899.1	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (307 aa)
	AKB76065.1	2-isopropylmalate synthase. (440 aa)
	AKB76066.1	3-isopropylmalate dehydrogenase. (342 aa)
	AKB76372.1	Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)
	AKB76373.1	Pyruvate:ferredoxin oxidoreductase, alpha subunit. (403 aa)
	AKB76374.1	Pyruvate:ferredoxin oxidoreductase, delta subunit. (86 aa)
	AKB76375.1	Pyruvate:ferredoxin oxidoreductase, gamma subunit. (182 aa)

Your Current Organism:

Methanosarcina lacustris

NCBI taxonomy Id: 1434111
Other names: M. lacustris Z-7289, Methanosarcina lacustris Z-7289

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB73350.1	AKB73351.1	MSLAZ_0089	MSLAZ_0090	Aconitate hydratase.	Citrate synthase (si).	0.999
AKB73350.1	AKB75451.1	MSLAZ_0089	MSLAZ_2190	Aconitate hydratase.	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase beta subunit.	0.576
AKB73350.1	AKB75452.1	MSLAZ_0089	MSLAZ_2191	Aconitate hydratase.	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase alpha subunit.	0.636
AKB73350.1	AKB75899.1	MSLAZ_0089	MSLAZ_2638	Aconitate hydratase.	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.750
AKB73350.1	AKB76065.1	MSLAZ_0089	MSLAZ_2804	Aconitate hydratase.	2-isopropylmalate synthase.	0.933
AKB73350.1	AKB76066.1	MSLAZ_0089	MSLAZ_2805	Aconitate hydratase.	3-isopropylmalate dehydrogenase.	0.957
AKB73351.1	AKB73350.1	MSLAZ_0090	MSLAZ_0089	Citrate synthase (si).	Aconitate hydratase.	0.999
AKB73351.1	AKB73699.1	MSLAZ_0090	MSLAZ_0438	Citrate synthase (si).	Pyruvate carboxyl transferase subunit A.	0.937
AKB73351.1	AKB73700.1	MSLAZ_0090	MSLAZ_0439	Citrate synthase (si).	Pyruvate carboxyl transferase subunit B.	0.921
AKB73351.1	AKB75371.1	MSLAZ_0090	MSLAZ_2110	Citrate synthase (si).	2-oxoglutarate oxidoreductase, beta subunit.	0.929
AKB73351.1	AKB75372.1	MSLAZ_0090	MSLAZ_2111	Citrate synthase (si).	2-oxoglutarate oxidoreductase, alpha subunit.	0.920
AKB73351.1	AKB75451.1	MSLAZ_0090	MSLAZ_2190	Citrate synthase (si).	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase beta subunit.	0.931
AKB73351.1	AKB75452.1	MSLAZ_0090	MSLAZ_2191	Citrate synthase (si).	Fumarate hydratase class I, aerobic; L(+)-tartrate dehydratase alpha subunit.	0.939
AKB73351.1	AKB75899.1	MSLAZ_0090	MSLAZ_2638	Citrate synthase (si).	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.996
AKB73351.1	AKB76065.1	MSLAZ_0090	MSLAZ_2804	Citrate synthase (si).	2-isopropylmalate synthase.	0.921
AKB73351.1	AKB76066.1	MSLAZ_0090	MSLAZ_2805	Citrate synthase (si).	3-isopropylmalate dehydrogenase.	0.833
AKB73351.1	AKB76372.1	MSLAZ_0090	MSLAZ_3111	Citrate synthase (si).	Pyruvate:ferredoxin oxidoreductase, beta subunit.	0.928
AKB73351.1	AKB76373.1	MSLAZ_0090	MSLAZ_3112	Citrate synthase (si).	Pyruvate:ferredoxin oxidoreductase, alpha subunit.	0.920
AKB73351.1	AKB76374.1	MSLAZ_0090	MSLAZ_3113	Citrate synthase (si).	Pyruvate:ferredoxin oxidoreductase, delta subunit.	0.911
AKB73351.1	AKB76375.1	MSLAZ_0090	MSLAZ_3114	Citrate synthase (si).	Pyruvate:ferredoxin oxidoreductase, gamma subunit.	0.918