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| | AKB38343.1 | Hypothetical protein. (260 aa) |
| | AKB38344.1 | Hypothetical protein. (273 aa) |
| | AKB38367.1 | Beta-ketoacyl synthase/thiolase. (390 aa) |
| | metG | Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (711 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | AKB38387.1 | Metal-dependent hydrolases of the beta-lactamase superfamily I; PhnP protein. (246 aa) |
| | AKB38409.1 | 3-isopropylmalate dehydrogenase. (342 aa) |
| | AKB38410.1 | 2-isopropylmalate synthase. (443 aa) |
| | AKB38455.1 | Glutamate synthase [NADPH] large chain; Belongs to the glutamate synthase family. (503 aa) |
| | AKB38456.1 | Glutamine amidotransferase, class-II. (350 aa) |
| | AKB38458.1 | Glutamine synthetase type I. (447 aa) |
| | AKB38483.1 | Hypothetical protein. (136 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | proB-2 | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (447 aa) |
| | AKB38570.1 | Aldehyde dehydrogenase. (476 aa) |
| | AKB38575.1 | Coenzyme F390 synthetase. (452 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa) |
| | AKB38682.1 | 7,8 dihydropteroate synthase (methanopterin). (220 aa) |
| | AKB38699.1 | Phosphoserine phosphatase. (285 aa) |
| | AKB38700.1 | Phosphoserine phosphatase. (231 aa) |
| | AKB38706.1 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein; Belongs to the HisA/HisF family. (238 aa) |
| | AKB38723.1 | UDP-glucose 6-dehydrogenase. (427 aa) |
| | AKB38736.1 | Acetyltransferase. (222 aa) |
| | AKB38771.1 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase. (230 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (263 aa) |
| | aroA-3 | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | pyrB | Aspartate carbamoyltransferase. (298 aa) |
| | AKB38941.1 | Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa) |
| | AKB38942.1 | Pyruvate:ferredoxin oxidoreductase, alpha subunit. (403 aa) |
| | AKB38943.1 | Pyruvate:ferredoxin oxidoreductase, delta subunit. (86 aa) |
| | AKB38944.1 | Pyruvate:ferredoxin oxidoreductase, gamma subunit. (182 aa) |
| | AKB38975.1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (347 aa) |
| | argS | Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (569 aa) |
| | AKB34622.1 | FAD/FMN-containing dehydrogenase. (456 aa) |
| | AKB34631.1 | Metallo-beta-lactamase. (213 aa) |
| | AKB34633.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (515 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (222 aa) |
| | AKB34648.1 | Prephenate and/or arogenate dehydrogenase (unknown specificity). (476 aa) |
| | aroE | Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | aroD | 3-dehydroquinate dehydratase I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (242 aa) |
| | aroB | 3,7-dideoxy-D-threo-hepto-2, 6-diulosonate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (380 aa) |
| | aroA | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (265 aa) |
| | guaAA | GMP synthase (glutamine-hydrolyzing), amidotransferase subunit; Catalyzes the synthesis of GMP from XMP. (189 aa) |
| | sepS | O-phosphoseryl-tRNA(Cys) synthetase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys). (539 aa) |
| | AKB34664.1 | Glycyl-tRNA synthetase. (613 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (439 aa) |
| | hisC | Aspartate aminotransferase / Histidinol-phosphate aminotransferase. (364 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | AKB34699.1 | Aspartokinase; Belongs to the aspartokinase family. (472 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa) |
| | cofE | Coenzyme F420:L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (254 aa) |
| | AKB34724.1 | Proline reductase for pyrrolysine biosynthesis. (259 aa) |
| | AKB34725.1 | Pyrrolysine synthetase. (363 aa) |
| | AKB34726.1 | Proline 2-methylase for pyrrolysine biosynthesis. (350 aa) |
| | pylS | Pyrrolysyl-tRNA synthetase; Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG. (443 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (492 aa) |
| | trpS | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). (441 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (925 aa) |
| | AKB34765.1 | 3-isopropylmalate dehydrogenase. (375 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (289 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (250 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (191 aa) |
| | AKB34813.1 | Cysteine desulfurase. (393 aa) |
| | AKB34820.1 | Aconitate hydratase X, predicted; Belongs to the UPF0107 family. (144 aa) |
| | AKB34821.1 | Hypothetical protein. (401 aa) |
| | AKB34972.1 | Aspartate-semialdehyde dehydrogenase. (342 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (242 aa) |
| | AKB35047.1 | Dimethylamine methyltransferase corrinoid protein. (208 aa) |
| | lysS | Lysyl-tRNA synthetase (class I); Belongs to the class-I aminoacyl-tRNA synthetase family. (538 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | AKB35107.1 | Fumarylacetoacetate hydrolase family protein. (244 aa) |
| | gltX | Glutamyl-tRNA synthetase / Glutamyl-tRNA(Gln) synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (571 aa) |
| | AKB35113.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (523 aa) |
| | AKB35126.1 | Pyruvate,phosphate dikinase. (865 aa) |
| | AKB35204.1 | Phosphoserine phosphatase. (319 aa) |
| | AKB35222.1 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase. (239 aa) |
| | AKB35240.1 | Succinate-semialdehyde dehydrogenase [NADP+]. (159 aa) |
| | AKB35241.1 | Succinate-semialdehyde dehydrogenase [NADP+]. (115 aa) |
| | cofD | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (307 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | cysS | Cysteinyl-tRNA synthetase. (473 aa) |
| | AKB35283.1 | Peptidase M20. (507 aa) |
| | lysS-2 | Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (511 aa) |
| | AKB35289.1 | Lysyl-tRNA synthetase (class II). (176 aa) |
| | AKB35290.1 | Imidazolonepropionase. (550 aa) |
| | AKB35337.1 | Homocysteine desulfhydrase. (384 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily. (317 aa) |
| | AKB35347.1 | Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (307 aa) |
| | AKB35349.1 | Glucose-6-phosphate isomerase. (246 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisS | Histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (413 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | AKB35567.1 | Hypothetical protein. (239 aa) |
| | AKB35646.1 | Phosphopantothenoylcysteine synthetase. (450 aa) |
| | AKB35679.1 | 2-haloalkanoic acid dehalogenase. (230 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. (395 aa) |
| | AKB35710.1 | Glutamate dehydrogenase 2; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (374 aa) |
| | AKB35731.1 | Metal-dependent hydrolase. (253 aa) |
| | AKB35735.1 | Acetyltransferase. (177 aa) |
| | AKB35775.1 | Shikimate kinase I. (194 aa) |
| | cbiA-2 | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (498 aa) |
| | AKB35831.1 | GMP synthase (glutamine-hydrolyzing). (248 aa) |
| | AKB35908.1 | Glutamine amidotransferase class-I. (234 aa) |
| | trpE | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (559 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (234 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (370 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | AKB35957.1 | Hypothetical protein. (61 aa) |
| | AKB35958.1 | Hypothetical protein. (42 aa) |
| | AKB35960.1 | Hydrolase, HAD superfamily. (263 aa) |
| | AKB35974.1 | Chorismate mutase I. (95 aa) |
| | aroK | Shikimate kinase II. (294 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (104 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa) |
| | AKB36000.1 | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. (258 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (208 aa) |
| | aspS | Aspartyl-tRNA synthetase / Aspartyl-tRNA(Asn) synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (444 aa) |
| | AKB36117.1 | Cysteine synthase. (316 aa) |
| | AKB36118.1 | Serine acetyltransferase; PaaD-like protein (DUF59) involved in Fe-S cluster assembly. (319 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1058 aa) |
| | AKB36153.1 | Dimethylamine methyltransferase corrinoid protein. (220 aa) |
| | AKB36171.1 | Hypothetical protein. (247 aa) |
| | AKB36178.1 | Glutamine synthetase type I. (506 aa) |
| | AKB36203.1 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (302 aa) |
| | AKB36211.1 | Hypothetical protein. (438 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | AKB36339.1 | Tetrahydromethanopterin:alpha-L-glutamate ligase. (324 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (396 aa) |
| | ala | Ornithine cyclodeaminase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (326 aa) |
| | AKB36356.1 | Cobyric acid synthase. (207 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (223 aa) |
| | AKB36371.1 | Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase. (171 aa) |
| | AKB38981.1 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (361 aa) |
| | AKB36372.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (828 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (515 aa) |
| | AKB36391.1 | Indolepyruvate oxidoreductase subunit IorB. (203 aa) |
| | AKB36392.1 | Phenylacetate-coenzyme A ligase. (435 aa) |
| | AKB36415.1 | Gly-tRNA(Ala) deacylase. (245 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (369 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1070 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (394 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (536 aa) |
| | AKB36479.1 | O-succinylhomoserine sulfhydrylase. (441 aa) |
| | AKB36480.1 | Quinolinate synthetase. (299 aa) |
| | iscS-2 | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (394 aa) |
| | gatD | Glutamyl-tRNA(Gln) amidotransferase asparaginase subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (424 aa) |
| | argH | Argininosuccinate lyase. (491 aa) |
| | AKB36494.1 | Short chain dehydrogenase. (118 aa) |
| | dtdA | D-tyrosyl-tRNA(Tyr) deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (297 aa) |
| | AKB36742.1 | Serine O-acetyltransferase. (143 aa) |
| | AKB36760.1 | Ferredoxin. (128 aa) |
| | AKB36761.1 | Inosine-5'-monophosphate dehydrogenase. (500 aa) |
| | AKB36766.1 | Serine--glyoxylate aminotransferase. (383 aa) |
| | AKB36791.1 | Asparagine synthetase (glutamine-hydrolyzing). (501 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (232 aa) |
| | AKB36795.1 | 7,8 dihydropteroate synthase (methanopterin). (280 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain. (545 aa) |
| | AKB36808.1 | Glutamate decarboxylase. (468 aa) |
| | AKB36810.1 | 7,8 dihydropteroate synthase (methanopterin). (37 aa) |
| | AKB36811.1 | 7,8 dihydropteroate synthase (methanopterin). (179 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (268 aa) |
| | pdxT | Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (199 aa) |
| | pdxS | Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | AKB36939.1 | Phenylacetate-coenzyme A ligase. (433 aa) |
| | AKB36942.1 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (808 aa) |
| | AKB36965.1 | Dimethylamine methyltransferase corrinoid protein. (214 aa) |
| | AKB37020.1 | NAD-dependent malic enzyme. (451 aa) |
| | AKB37031.1 | Serine O-acetyltransferase. (137 aa) |
| | AKB37072.1 | Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (417 aa) |
| | AKB37143.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 1, 6, and 10; Belongs to the alpha-IPM synthase/homocitrate synthase family. (405 aa) |
| | gap | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase archaeal. (335 aa) |
| | AKB37172.1 | Hypothetical protein. (505 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AKB37215.1 | Aminoacyl-histidine dipeptidase (Peptidase D). (506 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | AKB37309.1 | Ornithine decarboxylase. (390 aa) |
| | AKB37313.1 | Ketoisovalerate oxidoreductase subunit VorC. (82 aa) |
| | AKB37314.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (339 aa) |
| | AKB37315.1 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (177 aa) |
| | AKB37324.1 | Putative methyltransferase. (285 aa) |
| | AKB37412.1 | Methionine gamma-lyase. (394 aa) |
| | AKB37440.1 | 4-aminobutyrate aminotransferase. (445 aa) |
| | AKB37441.1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa) |
| | thrS | Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (635 aa) |
| | AKB37521.1 | Prephenate dehydratase. (313 aa) |
| | leuC-2 | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (869 aa) |
| | AKB37579.1 | Haloacid dehalogenase-like hydrolase. (217 aa) |
| | AKB37587.1 | Haloacid dehalogenase-like hydrolase. (254 aa) |
| | AKB37594.1 | Uroporphyrinogen-III synthase. (263 aa) |
| | AKB37627.1 | Succinate-semialdehyde dehydrogenase [NADP+]. (454 aa) |
| | pdaD | Pyruvoyl-dependent arginine decarboxylase 2; Belongs to the PdaD family. (190 aa) |
| | AKB37678.1 | Homoserine dehydrogenase. (332 aa) |
| | AKB37707.1 | Glutamine amidotransferase class-I. (234 aa) |
| | ppcA | Phosphoenolpyruvate carboxylase, archaeal; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (526 aa) |
| | pfkC | ADP-dependent phosphofructokinase; Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor. (491 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (395 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (337 aa) |
| | pgk-2 | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | glyA | Serine hydroxymethyltransferase / L-threonine aldolase / L-allo-threonine aldolase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | AKB37811.1 | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. (408 aa) |
| | AKB37813.1 | 5,10-methylenetetrahydrofolate reductase. (292 aa) |
| | AKB37815.1 | Coenzyme F420:L-glutamate ligase. (268 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa) |
| | trpB-2 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (432 aa) |
| | leuS | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (961 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | AKB37859.1 | Phosphoglycerate mutase family protein. (209 aa) |
| | pdaD-2 | Pyruvoyl-dependent arginine decarboxylase; Belongs to the PdaD family. (165 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (618 aa) |
| | AKB37892.1 | LL-diaminopimelate aminotransferase, methanococcal. (385 aa) |
| | AKB37909.1 | Putative capsular polysaccharide biosynthesis protein. (444 aa) |
| | AKB37927.1 | Putative amidohydrolase. (418 aa) |
| | AKB37299.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (405 aa) |
| | hacB | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (165 aa) |
| | AKB38036.1 | Indolepyruvate oxidoreductase subunit IorB. (200 aa) |
| | gap-2 | NAD(P)-dependent glyceraldehyde 3-phosphate dehydrogenase archaeal. (335 aa) |
| | AKB38144.1 | Metal-dependent hydrolase. (175 aa) |
| | AKB38145.1 | Metal-dependent hydrolase. (43 aa) |
| | AKB38146.1 | Coenzyme B synthesis from 2-oxoglutarate: steps 5, 9, and 13. (331 aa) |
| | hacB-2 | Coenzyme B synthesis from 2-oxoglutarate: steps 4, 7, 8, 11, and 12 (small subunit); Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis path [...] (166 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa) |
| | AKB38172.1 | Acetolactate synthase small subunit. (161 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. (483 aa) |
| | AKB38180.1 | long-chain-fatty-acid--CoA ligase. (434 aa) |
| | proS | Prolyl-tRNA synthetase, archaeal/eukaryal type; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (480 aa) |
| | AKB38216.1 | Fructose-bisphosphate aldolase/6-deoxy-5-ketofructose 1-phosphate synthase. (280 aa) |
| | AKB38217.1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (503 aa) |
| | AKB38304.1 | Lysine 2,3-aminomutase. (419 aa) |
| | AKB38318.1 | Hypothetical protein. (415 aa) |
| | gpmI-2 | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (517 aa) |
