STRINGSTRING
priL priL AHC52175.1 AHC52175.1 AHC50596.1 AHC50596.1 dnaG dnaG dbh dbh AHC51098.1 AHC51098.1 fen fen lig lig pcn pcn pcn-2 pcn-2 rgy rgy AHC51241.1 AHC51241.1 AHC51244.1 AHC51244.1 rfcL rfcL rfc rfc priS priS pcn-3 pcn-3 top6A top6A top6B top6B AHC51589.1 AHC51589.1 AHC51619.1 AHC51619.1 AHC51755.1 AHC51755.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (299 aa)
AHC52175.1DNA polymerase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
AHC50596.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (782 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (412 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (354 aa)
AHC51098.1Cell division control protein Cdc6; Involved in regulation of DNA replication. (397 aa)
fenEndonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] (302 aa)
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (598 aa)
pcnDNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (250 aa)
pcn-2DNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
rgyReverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1248 aa)
AHC51241.1Minichromosome maintenance protein MCM; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MCM family. (688 aa)
AHC51244.1Cell division control protein Cdc6; Involved in regulation of DNA replication. (418 aa)
rfcLReplication protein C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (437 aa)
rfcATPase AAA; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (325 aa)
priSDNA primase; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play [...] (322 aa)
pcn-3DNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (245 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (386 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (532 aa)
AHC51589.1Topoisomerase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication. (1153 aa)
AHC51619.1Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (837 aa)
AHC51755.1Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein has been shown to be aphidicolin resistant and stable up to 80#C; Derived by automated computational analysis using gene prediction method: Protein Homology. (876 aa)
Your Current Organism:
Sulfolobus acidocaldarius SUSAZ
NCBI taxonomy Id: 1435377
Other names: S. acidocaldarius SUSAZ
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