STRINGSTRING
AHC50672.1 AHC50672.1 AHC50547.1 AHC50547.1 AHC52384.1 AHC52384.1 rad50 rad50 mre11 mre11 AHC50579.1 AHC50579.1 AHC50648.1 AHC50648.1 AHC50674.1 AHC50674.1 AHC50702.1 AHC50702.1 hel308 hel308 AHC50783.1 AHC50783.1 nfi nfi dbh dbh AHC51010.1 AHC51010.1 radA radA fen fen lig lig AHC51237.1 AHC51237.1 AHC51311.1 AHC51311.1 AHC51399.1 AHC51399.1 AHC51435.1 AHC51435.1 AHC51436.1 AHC51436.1 AHC51514.1 AHC51514.1 ogt ogt AHC51546.1 AHC51546.1 ogg ogg AHC51666.1 AHC51666.1 AHC51732.1 AHC51732.1 hjc hjc AHC51934.1 AHC51934.1 AHC51947.1 AHC51947.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AHC50672.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
AHC50547.1Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AHC52384.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (332 aa)
rad50Double-stranded DNA repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (886 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (382 aa)
AHC50579.1HerA recombination helicase like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
AHC50648.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
AHC50674.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AHC50702.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
hel308DEAD/DEAH box helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (705 aa)
AHC50783.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (746 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (196 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (354 aa)
AHC51010.1Multidrug MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (321 aa)
fenEndonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as [...] (302 aa)
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (598 aa)
AHC51237.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
AHC51311.1Single-stranded DNA-binding protein; In Sulfolobus solfataricus this protein plays a role in promoter opening and RNA polymerase recruitment under specific conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
AHC51399.1UV damage endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AHC51435.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AHC51436.1Hypothetical protein; Involved in DNA damage repair. (397 aa)
AHC51514.1Deoxyribodipyrimidine photo-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA photolyase family. (430 aa)
ogtmethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (155 aa)
AHC51546.1DNA endonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
oggDNA lyase; Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites); Belongs to the type-2 OGG1 family. (203 aa)
AHC51666.1Hypothetical protein; Involved in DNA damage repair. (401 aa)
AHC51732.1Endonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
hjcEndonuclease; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (143 aa)
AHC51934.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
AHC51947.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
Your Current Organism:
Sulfolobus acidocaldarius SUSAZ
NCBI taxonomy Id: 1435377
Other names: S. acidocaldarius SUSAZ
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.