STRINGSTRING
AHC50557.1 AHC50557.1 AHC50588.1 AHC50588.1 nucS nucS hel308 hel308 AHC50860.1 AHC50860.1 dbh dbh tfe tfe radA radA pcn pcn pcn-2 pcn-2 spt4 spt4 rgy rgy AHC51241.1 AHC51241.1 AHC51311.1 AHC51311.1 AHC51408.1 AHC51408.1 AHC51482.1 AHC51482.1 pcn-3 pcn-3 creN7 creN7 top6A top6A top6B top6B AHC51588.1 AHC51588.1 AHC51589.1 AHC51589.1 albA albA tbp tbp AHC51611.1 AHC51611.1 hjc hjc AHC51625.1 AHC51625.1 AHC51706.1 AHC51706.1 xerA xerA AHC51999.1 AHC51999.1 AHC52256.1 AHC52256.1 AHC52257.1 AHC52257.1 AHC52313.1 AHC52313.1 AHC52318.1 AHC52318.1 AHC51755.1 AHC51755.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AHC50557.1Nucleotide binding protein PINc; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
AHC50588.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
nucSHypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (250 aa)
hel308DEAD/DEAH box helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (705 aa)
AHC50860.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (354 aa)
tfeTranscription factor; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to [...] (179 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (321 aa)
pcnDNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (250 aa)
pcn-2DNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
spt4DNA-binding protein; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (68 aa)
rgyReverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1248 aa)
AHC51241.1Minichromosome maintenance protein MCM; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MCM family. (688 aa)
AHC51311.1Single-stranded DNA-binding protein; In Sulfolobus solfataricus this protein plays a role in promoter opening and RNA polymerase recruitment under specific conditions; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
AHC51408.1TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AHC51482.1Molybdenum transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
pcn-3DNA polymerase; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (245 aa)
creN7Chorismate-binding protein; A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils. Belongs to the Cren7 family. (59 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (386 aa)
top6BDNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (532 aa)
AHC51588.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
AHC51589.1Topoisomerase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication. (1153 aa)
albADNA-binding protein; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (97 aa)
tbpTATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (166 aa)
AHC51611.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
hjcEndonuclease; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (143 aa)
AHC51625.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AHC51706.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PDCD5 family. (115 aa)
xerARecombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Belongs to the 'phage' integrase family. XerA subfamily. (287 aa)
AHC51999.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
AHC52256.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AHC52257.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AHC52313.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
AHC52318.1Bacterio-opsin activator; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
AHC51755.1Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein has been shown to be aphidicolin resistant and stable up to 80#C; Derived by automated computational analysis using gene prediction method: Protein Homology. (876 aa)
Your Current Organism:
Sulfolobus acidocaldarius SUSAZ
NCBI taxonomy Id: 1435377
Other names: S. acidocaldarius SUSAZ
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