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AHC50570.1 AHC50570.1 tpiA tpiA AHC50677.1 AHC50677.1 AHC50690.1 AHC50690.1 AHC50691.1 AHC50691.1 AHC50692.1 AHC50692.1 AHC50693.1 AHC50693.1 aroB aroB aroE aroE aroC aroC aroK aroK AHC50698.1 AHC50698.1 aroD aroD AHC50747.1 AHC50747.1 leuD leuD leuC leuC AHC50904.1 AHC50904.1 AHC50941.1 AHC50941.1 AHC50968.1 AHC50968.1 AHC51006.1 AHC51006.1 fbp fbp AHC51088.1 AHC51088.1 AHC51089.1 AHC51089.1 AHC51107.1 AHC51107.1 lysY lysY lysZ lysZ AHC51114.1 AHC51114.1 lysJ lysJ lysK lysK mat mat AHC51154.1 AHC51154.1 AHC51176.1 AHC51176.1 metE metE apgM apgM AHC51277.1 AHC51277.1 AHC51307.1 AHC51307.1 thrB thrB AHC51346.1 AHC51346.1 AHC51433.1 AHC51433.1 AHC51448.1 AHC51448.1 AHC51503.1 AHC51503.1 prs prs AHC51573.1 AHC51573.1 AHC51574.1 AHC51574.1 pgk pgk gap gap glyA glyA AHC51630.1 AHC51630.1 eno eno AHC51665.1 AHC51665.1 AHC51668.1 AHC51668.1 AHC51669.1 AHC51669.1 AHC51670.1 AHC51670.1 trpB trpB trpA trpA trpD trpD trpF trpF trpE trpE AHC51682.1 AHC51682.1 trpC trpC AHC51684.1 AHC51684.1 AHC51721.1 AHC51721.1 ilvC ilvC AHC51778.1 AHC51778.1 AHC51790.1 AHC51790.1 hisG hisG AHC51792.1 AHC51792.1 hisB hisB hisF hisF hisD hisD hisE hisE hisH hisH AHC51798.1 AHC51798.1 argG argG argH argH AHC51836.1 AHC51836.1 AHC51847.1 AHC51847.1 AHC51855.1 AHC51855.1 AHC51858.1 AHC51858.1 ilvD ilvD aroE-2 aroE-2 AHC52149.1 AHC52149.1 AHC52158.1 AHC52158.1 AHC52304.1 AHC52304.1 AHC52343.1 AHC52343.1 AHC52380.1 AHC52380.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AHC50570.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa)
AHC50677.1Dihydrodipicolinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AHC50690.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
AHC50691.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
AHC50692.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
AHC50693.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (353 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (263 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa)
aroKShikimate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
AHC50698.13-phosphoshikimate 1-carboxyvinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (216 aa)
AHC50747.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa)
AHC50904.1Aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AHC50941.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AHC50968.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (427 aa)
AHC51006.1Catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate and the decarboxylation of 3-methylmalate to 2-oxobutyrate and of D-malate to pyruvate; involved in leucine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
fbpFructose-1 6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (385 aa)
AHC51088.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
AHC51089.1Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AHC51107.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
lysYN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (350 aa)
lysZAcetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (261 aa)
AHC51114.1alpha-aminoadipate--lysW ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
lysJAcetyl-lysine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (387 aa)
lysKAcetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (346 aa)
matS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (403 aa)
AHC51154.1D-arabino 3-hexulose 6-phosphate aldehyde lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AHC51176.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
metEMethionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. (339 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (413 aa)
AHC51277.1Trans-homoaconitate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)
AHC51307.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
AHC51346.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AHC51433.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (558 aa)
AHC51448.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
AHC51503.1Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (848 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (291 aa)
AHC51573.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
AHC51574.12-isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (415 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Catalyzes the formation of 3-phospho-D-glycerol phosphate from D-glyceraldehyde 3-phosphate in glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
AHC51630.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa)
AHC51665.1Ornithine carbamoyltransferase; Catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (306 aa)
AHC51668.1Aspartate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
AHC51669.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (446 aa)
AHC51670.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (392 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (424 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (241 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (199 aa)
trpEAnthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (432 aa)
AHC51682.1Anthranilate synthase subunit II; TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
trpCIndole-3-glycerol-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (248 aa)
AHC51684.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AHC51721.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (473 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
AHC51778.1Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
AHC51790.1Histidinol-phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa)
AHC51792.1Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HisA/HisF family. (226 aa)
hisBImidazoleglycerol-phosphate dehydratase; Catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (249 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (393 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (199 aa)
AHC51798.1phosphoribosyl-AMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (391 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AHC51836.130S ribosomal protein S6 modification protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AHC51847.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
AHC51855.1Succinyl-diaminopimelate desuccinylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
AHC51858.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (441 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (561 aa)
aroE-2AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AHC52149.1Succinyl-diaminopimelate desuccinylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
AHC52158.1Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (431 aa)
AHC52304.1Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (540 aa)
AHC52343.1Alpha-isopropylmalate/homocitrate synthase family transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (523 aa)
AHC52380.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
Your Current Organism:
Sulfolobus acidocaldarius SUSAZ
NCBI taxonomy Id: 1435377
Other names: S. acidocaldarius SUSAZ
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