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APT87975.1 APT87975.1 gabD2 gabD2 APT87990.1 APT87990.1 APT88004.1 APT88004.1 APT88025.1 APT88025.1 APT88027.1 APT88027.1 APT88062.1 APT88062.1 APT88064.1 APT88064.1 fabG fabG APT88066.1 APT88066.1 APT88083.1 APT88083.1 APT88110.1 APT88110.1 leuA leuA APT88159.1 APT88159.1 sdhA sdhA APT88161.1 APT88161.1 APT88168.1 APT88168.1 APT88170.1 APT88170.1 APT88347.1 APT88347.1 APT88348.1 APT88348.1 APT88356.1 APT88356.1 APT88366.1 APT88366.1 APT88374.1 APT88374.1 APT88375.1 APT88375.1 APT88376.1 APT88376.1 APT88377.1 APT88377.1 APT88379.1 APT88379.1 APT88384.1 APT88384.1 APT88386.1 APT88386.1 fabG-2 fabG-2 APT88479.1 APT88479.1 APT88492.1 APT88492.1 APT88544.1 APT88544.1 APT88551.1 APT88551.1 purU purU aspA aspA APT88592.1 APT88592.1 APT88593.1 APT88593.1 APT88597.1 APT88597.1 APT88604.1 APT88604.1 APT88605.1 APT88605.1 APT88606.1 APT88606.1 APT88607.1 APT88607.1 selD selD glcB glcB APT88619.1 APT88619.1 APT88670.1 APT88670.1 APT88671.1 APT88671.1 APT88672.1 APT88672.1 APT88726.1 APT88726.1 APT88742.1 APT88742.1 APT88743.1 APT88743.1 ppc ppc acnA acnA APT88867.1 APT88867.1 APT88868.1 APT88868.1 APT88869.1 APT88869.1 leuD leuD leuC leuC APT88962.1 APT88962.1 leuB leuB ilvC ilvC APT88979.1 APT88979.1 ilvD ilvD APT89009.1 APT89009.1 APT89010.1 APT89010.1 mqo mqo APT89149.1 APT89149.1 APT89250.1 APT89250.1 APT89287.1 APT89287.1 APT89319.1 APT89319.1 mdh mdh APT89389.1 APT89389.1 APT89390.1 APT89390.1 APT89396.1 APT89396.1 APT89421.1 APT89421.1 APT89429.1 APT89429.1 acpS acpS APT89493.1 APT89493.1 APT89528.1 APT89528.1 APT89569.1 APT89569.1 APT89570.1 APT89570.1 ackA ackA APT89588.1 APT89588.1 APT89636.1 APT89636.1 pckG pckG APT89657.1 APT89657.1 APT89686.1 APT89686.1 ldh ldh APT89730.1 APT89730.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APT87975.13-hydroxy-2-methylbutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (257 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
APT87990.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa)
APT88004.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
APT88025.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
APT88027.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
APT88062.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
APT88064.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
fabG3-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
APT88066.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (432 aa)
APT88083.1NADPH:quinone dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
APT88110.1acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (606 aa)
APT88159.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (670 aa)
APT88161.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
APT88168.1ACP S-malonyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3139 aa)
APT88170.1Long-chain fatty acid--CoA ligase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
APT88347.1Fumarate hydrolyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
APT88348.1Involved in the tartrate degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
APT88356.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
APT88366.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (484 aa)
APT88374.12-methylcitrate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
APT88375.1Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (308 aa)
APT88376.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
APT88377.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa)
APT88379.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (590 aa)
APT88384.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
APT88386.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
fabG-23-ketoacyl-ACP reductase; Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
APT88479.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (430 aa)
APT88492.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (486 aa)
APT88544.13-hydroxyisobutyryl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
APT88551.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
APT88592.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
APT88593.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
APT88597.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (287 aa)
APT88604.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
APT88605.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (903 aa)
APT88606.14Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
APT88607.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
selDSegregation protein B; Synthesizes selenophosphate from selenide and ATP. (334 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (736 aa)
APT88619.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
APT88670.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
APT88671.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
APT88672.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
APT88726.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
APT88742.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (506 aa)
APT88743.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (922 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (938 aa)
APT88867.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
APT88868.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
APT88869.1Pyruvate formate lyase-activating protein; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (291 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (472 aa)
APT88962.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (340 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
APT88979.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (616 aa)
APT89009.1Electron transfer flavoprotein subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
APT89010.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
mqoMalate:quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
APT89149.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
APT89250.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
APT89287.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
APT89319.1Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (614 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (324 aa)
APT89389.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
APT89390.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (386 aa)
APT89396.13-ketoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
APT89421.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
APT89429.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
acpS4'-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (132 aa)
APT89493.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
APT89528.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (582 aa)
APT89569.1Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
APT89570.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
APT89588.1Phosphotransacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
APT89636.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (606 aa)
APT89657.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
APT89686.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa)
APT89730.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
Your Current Organism:
Corynebacterium frankenforstense
NCBI taxonomy Id: 1437875
Other names: C. frankenforstense DSM 45800, Corynebacterium frankenforstense DSM 45800, Corynebacterium sp. ST18
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