STRINGSTRING
UA08_00663 UA08_00663 UA08_07245 UA08_07245 UA08_07223 UA08_07223 UA08_07180 UA08_07180 UA08_06674 UA08_06674 UA08_02780 UA08_02780 uba4 uba4 UA08_09115 UA08_09115
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UA08_00663ThiF domain-containing protein. (812 aa)
UA08_07245NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. (544 aa)
UA08_07223Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family. (585 aa)
UA08_07180Ubiquitin-activating enzyme E1 1; Belongs to the ubiquitin-activating E1 family. (1431 aa)
UA08_06674NEDD8-activating enzyme E1 catalytic subunit. (423 aa)
UA08_02780ThiF domain-containing protein. (392 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (482 aa)
UA08_09115Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (683 aa)
Your Current Organism:
Talaromyces atroroseus
NCBI taxonomy Id: 1441469
Other names: CBS 133442, DTO 178A4, IBT 32470, KAS 3778, T. atroroseus, Talaromyces atroroseus Yilmaz, Frisvad, Houbraken & Samson, 2013
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