STRINGSTRING
pif1 pif1 rmi2 rmi2 LOC103376349 LOC103376349 fbh1 fbh1 exd2 exd2 xrcc3 xrcc3 tdrd3 tdrd3 rad51d rad51d top3a top3a rpa3 rpa3 rmi1 rmi1 rad51c rad51c rad51 rad51 rpa1 rpa1 recql5 recql5 RPA1 RPA1 meiob meiob rpa2 rpa2 ENSSPAP00000017877 ENSSPAP00000017877 blm blm top3b top3b LOC103368048 LOC103368048 xrcc2 xrcc2 LOC103359841 LOC103359841 rad52 rad52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (629 aa)
rmi2RecQ mediated genome instability 2. (145 aa)
LOC103376349DNA meiotic recombinase 1. (219 aa)
fbh1F-box DNA helicase 1. (1078 aa)
exd2Exonuclease 3'-5' domain containing 2. (640 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa)
tdrd3Tudor domain containing 3. (788 aa)
rad51dRAD51 paralog D. (316 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1030 aa)
rpa3Replication protein A3. (122 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (716 aa)
rad51cRAD51 paralog C. (338 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
recql5RecQ helicase-like 5. (1018 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (597 aa)
meiobMethionine sulfoxide reductase B1b. (430 aa)
rpa2Replication protein A2. (293 aa)
ENSSPAP00000017877Uncharacterized protein. (1285 aa)
blmBLM RecQ like helicase. (1405 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
LOC103368048Helicase ATP-binding domain-containing protein. (374 aa)
xrcc2RECA_2 domain-containing protein. (320 aa)
LOC103359841Helicase C-terminal domain-containing protein. (1420 aa)
rad52RAD52 homolog, DNA repair protein. (386 aa)
Your Current Organism:
Stegastes partitus
NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.