(135 nodes) Cell cycle, and Cyclin-dependent protein kinase holoenzyme complex network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
	wee1	Wee1-like protein kinase. (620 aa)
	cdk15	Cyclin-dependent kinase 15; Belongs to the protein kinase superfamily. (459 aa)
	bub1	Uncharacterized protein. (1261 aa)
	plk3	Serine/threonine-protein kinase PLK. (668 aa)
	anapc10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
	LOC103368869	Cyclin B2; Belongs to the cyclin family. (388 aa)
	batf3	Basic leucine zipper transcription factor, ATF-like 3. (125 aa)
	nsl1	NSL1 component of MIS12 kinetochore complex. (258 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (362 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (433 aa)
	espl1	Extra spindle pole bodies like 1, separase. (2157 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC103358269	Cyclin E2; Belongs to the cyclin family. (383 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (605 aa)
	LOC103367279	Aurora kinase B; Belongs to the protein kinase superfamily. (332 aa)
	bicral	BRD4 interacting chromatin remodeling complex associated protein like. (800 aa)
	e2f1	E2F transcription factor 1. (471 aa)
	LOC103358853	Cyclin-dependent kinase inhibitor 1Cb. (216 aa)
	ENSSPAP00000004691	Uncharacterized protein. (267 aa)
	LOC103375195	Retinoblastoma-like 1 (p107). (506 aa)
	LOC103360555	EMAP like 1. (615 aa)
	ENSSPAP00000004955	Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (188 aa)
	spc24	SPC24 component of NDC80 kinetochore complex. (199 aa)
	ENSSPAP00000005228	Uncharacterized protein. (90 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	intu	Inturned planar cell polarity protein. (944 aa)
	ccnj	Cyclin J; Belongs to the cyclin family. (370 aa)
	rb1	Retinoblastoma 1. (909 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (496 aa)
	LOC103364951	Fizzy/cell division cycle 20 related 1b. (519 aa)
	pkmyt1	Protein kinase, membrane associated tyrosine/threonine 1. (583 aa)
	LOC103374609	Uncharacterized protein; Belongs to the cyclin family. (278 aa)
	spc25	SPC25 component of NDC80 kinetochore complex. (237 aa)
	e2f4	E2F transcription factor 4. (390 aa)
	LOC103374064	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (296 aa)
	cdk17	Cyclin dependent kinase 17. (526 aa)
	anapc13	Anaphase promoting complex subunit 13. (74 aa)
	EML4	EMAP like 4. (807 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (436 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (778 aa)
	tfdp1	Transcription factor. (413 aa)
	wee2	Wee1-like protein kinase. (534 aa)
	ENSSPAP00000009290	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (107 aa)
	e2f3	E2F transcription factor 3. (444 aa)
	LOC103362885	Cyclin-dependent kinase inhibitor 1A. (170 aa)
	CCNG2	Cyclin G2; Belongs to the cyclin family. (334 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
	LOC103374710	Cyclin-dependent kinase 16. (551 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	cdc20	Cell division cycle 20 homolog. (502 aa)
	LOC103367815	Cyclin G2; Belongs to the cyclin family. (334 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (328 aa)
	ccni	Cyclin I; Belongs to the cyclin family. (397 aa)
	ndc80	NDC80 kinetochore complex component. (638 aa)
	LOC103361725	Uncharacterized protein. (173 aa)
	LOC103353173	Uncharacterized protein. (183 aa)
	ENSSPAP00000013503	ANK_REP_REGION domain-containing protein. (371 aa)
	tpst1	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (346 aa)
	ENSSPAP00000014203	E2F_TDP domain-containing protein. (238 aa)
	LOC103370205	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (380 aa)
	ENSSPAP00000014724	HTH_Tnp_Tc3_2 domain-containing protein. (183 aa)
	LOC103358485	Si:dkey-76k16.6. (274 aa)
	LOC103358488	Si:dkey-76k16.5. (278 aa)
	cdc26	Cell division cycle 26 homolog. (97 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (204 aa)
	LOC103373063	Uncharacterized protein. (477 aa)
	cdc27	Cell division cycle 27. (803 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (299 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (398 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	cdca8	Cell division cycle associated 8. (278 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (707 aa)
	eml1	WD_REPEATS_REGION domain-containing protein. (232 aa)
	mis12	MIS12 kinetochore complex component. (231 aa)
	nek2	NIMA-related kinase 2. (429 aa)
	ENSSPAP00000017696	Cyclin D3; Belongs to the cyclin family. (216 aa)
	LOC103357941	Cyclin-dependent kinase inhibitor 1-like. (170 aa)
	LOC103369162	Uncharacterized protein. (564 aa)
	LOC103374293	Baculoviral IAP repeat containing 5a. (225 aa)
	ENSSPAP00000018523	E2F transcription factor 5. (144 aa)
	ENSSPAP00000018547	E2F transcription factor 5. (148 aa)
	ccnjl	Cyclin J-like; Belongs to the cyclin family. (422 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (805 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	incenp	Uncharacterized protein. (834 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (124 aa)
	LOC103368661	Uncharacterized protein. (507 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	CDC25B	Cell division cycle 25B. (573 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	PLK1	Serine/threonine-protein kinase PLK. (579 aa)
	anapc16	Anaphase promoting complex subunit 16. (129 aa)
	cntd2	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (388 aa)
	LOC103358604	Si:dkey-6i22.5. (258 aa)
	LOC103372062	Cyclin-dependent kinase inhibitor 1D. (188 aa)
	nuf2	UF2 component of NDC80 kinetochore complex. (454 aa)
	LOC103376074	Cyclin D2, a; Belongs to the cyclin family. (383 aa)
	ube2s	Ubiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (237 aa)
	LOC103369270	Cyclin-dependent kinase 17. (447 aa)
	cdk14	Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily. (423 aa)
	e2f2	Si:ch211-160f23.5. (447 aa)
	LOC103366989	Uncharacterized protein. (187 aa)
	dsn1	DSN1 component of MIS12 kinetochore complex. (338 aa)
	LOC103372520	WD_REPEATS_REGION domain-containing protein. (495 aa)
	bicra	BRD4 interacting chromatin remodeling complex associated protein. (1779 aa)
	nwd1	NACHT and WD repeat domain containing 1. (1409 aa)
	CCNO	Cyclin O; Belongs to the cyclin family. (307 aa)
	eml3	EMAP like 3. (895 aa)
	CASKIN2	CASK interacting protein 2. (1330 aa)
	ccnf	Cyclin F; Belongs to the cyclin family. (773 aa)
	LOC103361491	Uncharacterized protein. (339 aa)
	ankrd34b	Ankyrin repeat domain 34Bb. (563 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (164 aa)
	anapc1	Anaphase promoting complex subunit 1. (1982 aa)
	LOC103371827	Uncharacterized protein. (396 aa)
	ttk	Ttk protein kinase. (998 aa)
	ccnd2	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	LOC103376156	Uncharacterized protein. (125 aa)
	ccnb3	Cyclin B3; Belongs to the cyclin family. (427 aa)
	LOC103370865	Protein kinase domain-containing protein. (527 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (411 aa)
	cdkn1b	Cyclin-dependent kinase inhibitor 1Bb. (186 aa)
	tpx2	TPX2 microtubule nucleation factor. (703 aa)
	aurka	Aurora kinase A; Belongs to the protein kinase superfamily. (424 aa)
	LOC103368183	Cyclin Dx; Belongs to the cyclin family. (311 aa)
	fam89a	Family with sequence similarity 89 member A. (180 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (172 aa)
	ccnb1	Cyclin B1; Belongs to the cyclin family. (411 aa)
	LOC103358762	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
	LOC103372710	Retinoblastoma-like 2 (p130). (881 aa)
	ttc32	Tetratricopeptide repeat domain 32. (165 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASKIN2	ENSSPAP00000004955	ENSSPAP00000024891	ENSSPAP00000004955	CASK interacting protein 2.	Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily.	0.403
CASKIN2	LOC103358604	ENSSPAP00000024891	ENSSPAP00000021211	CASK interacting protein 2.	Si:dkey-6i22.5.	0.476
CASKIN2	LOC103368661	ENSSPAP00000024891	ENSSPAP00000019246	CASK interacting protein 2.	Uncharacterized protein.	0.482
CASKIN2	LOC103369270	ENSSPAP00000024891	ENSSPAP00000022008	CASK interacting protein 2.	Cyclin-dependent kinase 17.	0.403
CASKIN2	LOC103370205	ENSSPAP00000024891	ENSSPAP00000014519	CASK interacting protein 2.	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family.	0.410
CASKIN2	LOC103370865	ENSSPAP00000024891	ENSSPAP00000026441	CASK interacting protein 2.	Protein kinase domain-containing protein.	0.403
CASKIN2	LOC103371827	ENSSPAP00000024891	ENSSPAP00000025812	CASK interacting protein 2.	Uncharacterized protein.	0.410
CASKIN2	LOC103374710	ENSSPAP00000024891	ENSSPAP00000010436	CASK interacting protein 2.	Cyclin-dependent kinase 16.	0.403
CASKIN2	PLK1	ENSSPAP00000024891	ENSSPAP00000020468	CASK interacting protein 2.	Serine/threonine-protein kinase PLK.	0.421
CASKIN2	anapc10	ENSSPAP00000024891	ENSSPAP00000001732	CASK interacting protein 2.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.414
CASKIN2	anapc4	ENSSPAP00000024891	ENSSPAP00000019092	CASK interacting protein 2.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.476
CASKIN2	ankrd34b	ENSSPAP00000024891	ENSSPAP00000025457	CASK interacting protein 2.	Ankyrin repeat domain 34Bb.	0.403
CASKIN2	bub1	ENSSPAP00000024891	ENSSPAP00000000943	CASK interacting protein 2.	Uncharacterized protein.	0.482
CASKIN2	bub1b	ENSSPAP00000024891	ENSSPAP00000027150	CASK interacting protein 2.	BUB1 mitotic checkpoint serine/threonine kinase Bb.	0.482
CASKIN2	cdc27	ENSSPAP00000024891	ENSSPAP00000015941	CASK interacting protein 2.	Cell division cycle 27.	0.410
CASKIN2	cdk1	ENSSPAP00000024891	ENSSPAP00000005346	CASK interacting protein 2.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.403
CASKIN2	cdk14	ENSSPAP00000024891	ENSSPAP00000022408	CASK interacting protein 2.	Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily.	0.403
CASKIN2	cdk15	ENSSPAP00000024891	ENSSPAP00000000664	CASK interacting protein 2.	Cyclin-dependent kinase 15; Belongs to the protein kinase superfamily.	0.403
CASKIN2	cdk17	ENSSPAP00000024891	ENSSPAP00000007195	CASK interacting protein 2.	Cyclin dependent kinase 17.	0.403
CASKIN2	cdk2	ENSSPAP00000024891	ENSSPAP00000003160	CASK interacting protein 2.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.403