(79 nodes) Response to ionizing radiation network (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdca7	Cell division cycle associated 7a. (404 aa)
	INIP	INTS3 and NABP interacting protein. (102 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (625 aa)
	ENSSPAP00000000091	TRAF family member-associated NFKB activator. (242 aa)
	cop1	COP1 E3 ubiquitin ligase. (717 aa)
	brcc3	BRCA1/BRCA2-containing complex, subunit 3. (265 aa)
	rfwd3	Ring finger and WD repeat domain 3. (727 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1518 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (340 aa)
	rhno1	Si:ch73-352p4.5. (297 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	ENSSPAP00000010532	Uncharacterized protein. (142 aa)
	cryab	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (162 aa)
	ino80	INO80 complex ATPase subunit. (1467 aa)
	LOC103372265	Protein kinase domain-containing protein. (578 aa)
	LOC103370652	Endo/exonuclease/phosphatase domain-containing protein. (328 aa)
	LOC103355069	Sterile alpha motif and leucine zipper containing kinase AZK. (298 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (455 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (695 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	fbxo4	F-box protein 4. (407 aa)
	cdca7l	zf-4CXXC_R1 domain-containing protein. (408 aa)
	ints3	Integrator complex subunit 3. (1019 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (783 aa)
	xrcc2	RECA_2 domain-containing protein. (320 aa)
	ENSSPAP00000024086	BH4_2 domain-containing protein. (205 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (827 aa)
	atm	Non-specific serine/threonine protein kinase. (3048 aa)
	tmem109	Uncharacterized protein. (286 aa)
	ENSSPAP00000021755	FHA domain-containing protein. (91 aa)
	LOC103355283	DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (396 aa)
	SPIDR	Scaffold protein involved in DNA repair. (953 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
	ENSSPAP00000019701	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (632 aa)
	LOC103360134	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (563 aa)
	blm	BLM RecQ like helicase. (1405 aa)
	babam2	BRISC and BRCA1 A complex member 2. (332 aa)
	ENSSPAP00000017877	Uncharacterized protein. (1285 aa)
	ENSSPAP00000017726	BRCA1-associated ATM activator 1. (722 aa)
	dcun1d3	DCN1-like protein. (325 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	LOC103371748	Uncharacterized protein. (297 aa)
	bard1	BRCA1 associated RING domain 1. (814 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (598 aa)
	xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5. (769 aa)
	babam1	BRISC and BRCA1 A complex member 1. (378 aa)
	LOC103375194	Uncharacterized protein. (399 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1045 aa)
	nabp1	Nucleic acid binding protein 1a. (220 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2496 aa)
	brca1	Uncharacterized protein. (1411 aa)
	LOC103354439	Deoxyribonuclease 1 like 4, tandem duplicate 1. (327 aa)
	ENSSPAP00000003143	Uncharacterized protein. (100 aa)
	LOC103360500	Uncharacterized protein. (446 aa)
	lig4	DNA ligase. (910 aa)
	ENSSPAP00000001654	Uncharacterized protein. (362 aa)
	swi5	SWI5 homologous recombination repair protein. (136 aa)
	ect2	Epithelial cell transforming 2. (1044 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (444 aa)
	bcl2	BCL2 apoptosis regulator b. (228 aa)
	ENSSPAP00000030409	Uncharacterized protein. (174 aa)
	LOC103373263	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1561 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	LOC103364319	Excision repair cross-complementation group 6. (1449 aa)
	ENSSPAP00000029580	Uncharacterized protein. (482 aa)
	ercc8	Excision repair cross-complementation group 8. (401 aa)
	LOC103357552	Zgc:153993. (205 aa)
	ercc1	Excision repair cross-complementation group 1. (361 aa)
	ticrr	Uncharacterized protein. (1749 aa)
	LOC103361519	Ints3 and nabp interacting protein. (103 aa)
	kars1	Lysine--tRNA ligase. (685 aa)
	LOC103371952	Uncharacterized protein. (341 aa)
	fancd2	FA complementation group D2. (1421 aa)
	LOC103369363	X-ray repair complementing defective repair in Chinese hamster cells 4. (336 aa)
	men1	Multiple endocrine neoplasia I. (626 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (855 aa)

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000000091	ENSSPAP00000003143	ENSSPAP00000000091	ENSSPAP00000003143	TRAF family member-associated NFKB activator.	Uncharacterized protein.	0.403
ENSSPAP00000000091	LOC103355069	ENSSPAP00000000091	ENSSPAP00000009055	TRAF family member-associated NFKB activator.	Sterile alpha motif and leucine zipper containing kinase AZK.	0.491
ENSSPAP00000000091	LOC103372265	ENSSPAP00000000091	ENSSPAP00000009546	TRAF family member-associated NFKB activator.	Protein kinase domain-containing protein.	0.491
ENSSPAP00000001654	ptprc	ENSSPAP00000001654	ENSSPAP00000004799	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.460
ENSSPAP00000001654	xrcc5	ENSSPAP00000001654	ENSSPAP00000005059	Uncharacterized protein.	X-ray repair complementing defective repair in Chinese hamster cells 5.	0.461
ENSSPAP00000003143	ENSSPAP00000000091	ENSSPAP00000003143	ENSSPAP00000000091	Uncharacterized protein.	TRAF family member-associated NFKB activator.	0.403
ENSSPAP00000003143	ENSSPAP00000017877	ENSSPAP00000003143	ENSSPAP00000017877	Uncharacterized protein.	Uncharacterized protein.	0.512
ENSSPAP00000003143	ENSSPAP00000021755	ENSSPAP00000003143	ENSSPAP00000021755	Uncharacterized protein.	FHA domain-containing protein.	0.824
ENSSPAP00000003143	ENSSPAP00000029580	ENSSPAP00000003143	ENSSPAP00000029580	Uncharacterized protein.	Uncharacterized protein.	0.831
ENSSPAP00000003143	ENSSPAP00000030409	ENSSPAP00000003143	ENSSPAP00000030409	Uncharacterized protein.	Uncharacterized protein.	0.723
ENSSPAP00000003143	LOC103354439	ENSSPAP00000003143	ENSSPAP00000003341	Uncharacterized protein.	Deoxyribonuclease 1 like 4, tandem duplicate 1.	0.403
ENSSPAP00000003143	LOC103370652	ENSSPAP00000003143	ENSSPAP00000009072	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.403
ENSSPAP00000003143	LOC103375194	ENSSPAP00000003143	ENSSPAP00000004816	Uncharacterized protein.	Uncharacterized protein.	0.403
ENSSPAP00000003143	abraxas1	ENSSPAP00000003143	ENSSPAP00000011394	Uncharacterized protein.	Abraxas 1, BRCA1 A complex subunit.	0.615
ENSSPAP00000003143	atm	ENSSPAP00000003143	ENSSPAP00000022487	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.731
ENSSPAP00000003143	babam1	ENSSPAP00000003143	ENSSPAP00000005023	Uncharacterized protein.	BRISC and BRCA1 A complex member 1.	0.996
ENSSPAP00000003143	babam2	ENSSPAP00000003143	ENSSPAP00000018316	Uncharacterized protein.	BRISC and BRCA1 A complex member 2.	0.995
ENSSPAP00000003143	bard1	ENSSPAP00000003143	ENSSPAP00000005852	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.935
ENSSPAP00000003143	brca1	ENSSPAP00000003143	ENSSPAP00000003607	Uncharacterized protein.	Uncharacterized protein.	0.991
ENSSPAP00000003143	brcc3	ENSSPAP00000003143	ENSSPAP00000012901	Uncharacterized protein.	BRCA1/BRCA2-containing complex, subunit 3.	0.995